IMECS

Identification of Mechanisms Correlating with Susceptibility for Avian Influenza

 Coordinatore RIJKSINSTITUUT VOOR VOLKSGEZONDHEIDEN MILIEU*NATIONAL INSTITUTEFOR PUBLIC HEALTH AND THE ENVIRONMENTEN 

 Organization address address: Antonie Van Leeuwenhoeklaan 9
city: BILTHOVEN
postcode: 3721 MA

contact info
Titolo: Ms.
Nome: Marjon
Cognome: Hartwigsen
Email: send email
Telefono: 31302742038
Fax: 31302744486

 Nazionalità Coordinatore Netherlands [NL]
 Totale costo 3˙668˙819 €
 EC contributo 2˙797˙287 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-A
 Funding Scheme CP-FP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-04-01   -   2012-12-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    RIJKSINSTITUUT VOOR VOLKSGEZONDHEIDEN MILIEU*NATIONAL INSTITUTEFOR PUBLIC HEALTH AND THE ENVIRONMENTEN

 Organization address address: Antonie Van Leeuwenhoeklaan 9
city: BILTHOVEN
postcode: 3721 MA

contact info
Titolo: Ms.
Nome: Marjon
Cognome: Hartwigsen
Email: send email
Telefono: 31302742038
Fax: 31302744486

NL (BILTHOVEN) coordinator 0.00
2    "MINISTERIE VAN VOLKSGEZONDHEID, WELZIJN EN SPORT"

 Organization address address: PARNASSUSPLEIN 5
city: DEN HAAG
postcode: 2500 EJ

contact info
Titolo: Mr.
Nome: Ernst
Cognome: Soethout
Email: send email
Telefono: +3130 2743200
Fax: +31 302744439

NL (DEN HAAG) participant 0.00
3    ACADEMISCH ZIEKENHUIS LEIDEN

 Organization address address: Albinusdreef 2
city: LEIDEN
postcode: 2333 ZA

contact info
Titolo: Ms.
Nome: Sonja
Cognome: Croes
Email: send email
Telefono: +31 715264765
Fax: +31 715266831

NL (LEIDEN) participant 0.00
4    FONDAZIONE ANDREA CESALPINO

 Organization address address: VIA SICILIA 169
city: ROMA
postcode: 197

contact info
Titolo: Mr.
Nome: Luigino
Cognome: Mangiapelo
Email: send email
Telefono: +39 064453994
Fax: +39 0649383333

IT (ROMA) participant 0.00
5    FONDAZIONE PER L'ISTITUTO DI RICERC A IN BIOMEDICINA

 Organization address address: Via Vincenzo Vela 6
city: BELLINZONA
postcode: 6500

contact info
Titolo: Ms.
Nome: Fosca
Cognome: Bognuda
Email: send email
Telefono: +41 91 820 03 00
Fax: +41 91 820 03 02

CH (BELLINZONA) participant 0.00
6    ISTITUTO SUPERIORE DI SANITA

 Organization address address: Viale Regina Elena 299
city: ROMA
postcode: 161

contact info
Titolo: Dr.
Nome: Rosa Maria
Cognome: Martoccia
Email: send email
Telefono: +39 06 4990 2688
Fax: +39 06 4990 3007

IT (ROMA) participant 0.00
7    TERVEYDEN JA HYVINVOINNIN LAITOS

 Organization address address: MANNERHEIMINTIE 166
city: HELSINKI
postcode: 300

contact info
Titolo: Mr.
Nome: Jaakko
Cognome: Penttinen
Email: send email
Telefono: +358 20 610 8203
Fax: +358 20 610 8225

FI (HELSINKI) participant 0.00
8    VIEN VE SINH DICH TE TRUNG UONG

 Organization address address: YERSIN STREET HAI BA TRUNG 1
city: HANOI
postcode: 1000

contact info
Titolo: Prof.
Nome: Duc Anh
Cognome: Dang
Email: send email
Telefono: 8449712989
Fax: 8448212660

VN (HANOI) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

humans    clinical    vaccination    global    threat    disease    vaccines    candidates    screening    imecs    immune    determining    immunity    groups    avian    human    ai    protection    vaccine    protective    pandemic    mechanisms    homologous    influenza   

 Obiettivo del progetto (Objective)

'IMECS is a proposal of the FLUSECURE network aimed at combating the threat of new and re-emerging forms of highly pathogenic influenza in its first stages of a disease by identifying mechanisms of protection that are essential for a solid immune response to avian influenza. IMECS is uniquely featured by correlating research in humans directly to protection from influenza. The IMECS initiative was introduced since the recent H5N1 avian influenza vaccine trials results have shown limited success in inducing a protective immune response as compared to the standard human influenza vaccines. This despite large investments and multiple vaccine formulations tested. These results make clear that the mechanisms of immunity for avian influenza are inherently different from those for human/seasonal influenza. The IMECS initiative aims to elucidate these mechanisms and aims to provide essential knowledge for development of breakthrough pandemic vaccines as a result. The initiative thereto boosts the development of AI-correlates of protection for the clinical screening of vaccine candidates in healthy adults and in different target groups, the origin of subclinical AI infection in humans, as well as a research programme for the screening of vaccine candidates in vitro. The following research objectives are pursued: - Determining the basis of the homologous and non-homologous mechanisms of protection for avian influenza; - Determine the mechanisms of protection in specific target groups, including infants and the elderly; - Determining the AI-specific response after vaccination in clinical trial studies. IMECS combines the knowledge of leading European universities and research centres. The multidisciplinary consortium has the resources, skills and knowledge to realize the objectives of this collaborative research project.The consortium consists of 6 partners and two subcontractors from five different European countries and one disease endemic country (SICA)'

Introduzione (Teaser)

Pandemic influenza remains a global threat, and may have a severe impact on world health and the global economy. Given that large parts of the population lack anti-influenza immunity, it is crucial that we study the protective immune mechanisms at work following vaccination.

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