EURIPIDES

EUropean Research initiative to develop Imaging Probes for early In-vivo Diagnosis and Evaluation of response to therapeutic Substances

 Coordinatore UNIVERSITY COLLEGE LONDON 

 Organization address address: GOWER STREET
city: LONDON
postcode: WC1E 6BT

contact info
Titolo: Ms.
Nome: Greta
Cognome: Borg-Carbott
Email: send email
Telefono: 442031000000
Fax: +44 20 3108 3096

 Nazionalità Coordinatore United Kingdom [UK]
 Sito del progetto http://www.euripides-europe.com/
 Totale costo 9˙086˙523 €
 EC contributo 6˙994˙850 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-A
 Funding Scheme CP-IP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-02-01   -   2012-07-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON

 Organization address address: GOWER STREET
city: LONDON
postcode: WC1E 6BT

contact info
Titolo: Ms.
Nome: Greta
Cognome: Borg-Carbott
Email: send email
Telefono: 442031000000
Fax: +44 20 3108 3096

UK (LONDON) coordinator 0.00
2    "NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS"""

 Organization address address: Patriarchou Gregoriou Str.
city: AGHIA PARASKEVI
postcode: 15310

contact info
Titolo: Ms.
Nome: Marina
Cognome: Fontara
Email: send email
Telefono: 302107000000
Fax: 302107000000

EL (AGHIA PARASKEVI) participant 0.00
3    AIT Austrian Institute of Technology GmbH

 Organization address address: Donau-City-Strasse 1
city: WIEN
postcode: 1220

contact info
Titolo: Dr.
Nome: Peter
Cognome: Euringer
Email: send email
Telefono: +43 050 550 2103
Fax: +43 050 550 2110

AT (WIEN) participant 0.00
4    GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG GAB O

 Organization address address: Oskar-von-Miller-Ring 29
city: MUENCHEN
postcode: 80333

contact info
Titolo: Ms.
Nome: Birgit
Cognome: Fuchs
Email: send email
Telefono: 49892881040
Fax: 498929000000

DE (MUENCHEN) participant 0.00
5    HOSPICES CIVILS DE LYON

 Organization address address: 3 Quai des Celestins
city: LYON
postcode: 69229

contact info
Titolo: Prof.
Nome: Philippe
Cognome: Ryvlin
Email: send email
Telefono: 33472684945
Fax: 33472684945

FR (LYON) participant 0.00
6    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539

contact info
Titolo: Prof.
Nome: Heidrun
Cognome: Potschka
Email: send email
Telefono: 498922000000
Fax: 4989342316

DE (MUENCHEN) participant 0.00
7    MEDIZINISCHE UNIVERSITAET WIEN

 Organization address address: SPITALGASSE 23
city: WIEN
postcode: 1090

contact info
Titolo: Prof.
Nome: Markus
Cognome: Müller
Email: send email
Telefono: +43140 4002981
Fax: +43140400 2998

AT (WIEN) participant 0.00
8    REGION HOVEDSTADEN

 Organization address address: KONGENS VAENGE 2
city: HILLEROD
postcode: 3400

contact info
Titolo: Prof.
Nome: Gitte Moos
Cognome: Knudsen
Email: send email
Telefono: +45 35456720
Fax: +45 35456713

DK (HILLEROD) participant 0.00
9    Stichting Epilepsie Instellingen Nederland

 Organization address address: Achterweg 5
city: Heemstede
postcode: 2103 SW

contact info
Titolo: Mr.
Nome: Jean Willem
Cognome: Barzilay
Email: send email
Telefono: +3123 5588401
Fax: +3123 5588409

NL (Heemstede) participant 0.00
10    STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER

 Organization address address: BUNTEWEG 2
city: HANNOVER
postcode: 30559

contact info
Titolo: Mr.
Nome: Peter
Cognome: Joppe
Email: send email
Telefono: 495120000000
Fax: 49512000000000

DE (HANNOVER) participant 0.00
11    THE UNIVERSITY OF LIVERPOOL

 Organization address address: Brownlow Hill, Foundation Building 765
city: LIVERPOOL
postcode: L69 7ZX

contact info
Titolo: Dr.
Nome: Jane
Cognome: Cloke
Email: send email
Telefono: +44 151 794 8726
Fax: +44 151 794 8728

UK (LIVERPOOL) participant 0.00
12    THE UNIVERSITY OF MANCHESTER

 Organization address address: OXFORD ROAD
city: MANCHESTER
postcode: M13 9PL

contact info
Titolo: Ms.
Nome: Liz
Cognome: Fay
Email: send email
Telefono: +44 161 275 7114
Fax: +44 161 275 2445

UK (MANCHESTER) participant 0.00
13    UNIVERSITEIT LEIDEN

 Organization address address: RAPENBURG 70
city: LEIDEN
postcode: 2300 RA

contact info
Titolo: Mr.
Nome: Ton
Cognome: Brouwer
Email: send email
Telefono: +31 71 527 3149
Fax: +31 71 527 5269

NL (LEIDEN) participant 0.00
14    VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG

 Organization address address: De Boelelaan 1105
city: AMSTERDAM
postcode: 1081 HV

contact info
Titolo: Prof.
Nome: Adriaan Anthonius
Cognome: Lammertsma
Email: send email
Telefono: +31 20 444 4214
Fax: +31 20 444 3090

NL (AMSTERDAM) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

prediction    ad    multidrug    impaired    patients    therapeutic    resistance    overexpression    underactivity    transporters    diseases    diagnosis    vivo    individual    contribution    imaging    function    brain    beta    transporter    cns    efflux    clearance    biomarker    drugs   

 Obiettivo del progetto (Objective)

'We aim develop in-vivo imaging biomarker of multidrug transporter function as a generic tool for the prediction, diagnosis, monitoring and prognosis of major CNS diseases, as well as to provide support and guidance for therapeutic interventions. Multidrug transporters actively transport substrates (including multiple CNS drugs) against concentration gradients across the blood-brain barrier (BBB). Overactivity of these efflux transporters results in inadequate access of CNS drugs to their targets and hampers the build up of adequate tissue levels of these drugs in the brain, greatly limiting their therapeutic efficacy. As such, this 'transporter hypothesis' of drug resistance is applicable to a broad range of CNS drugs and patients with a variety of CNS diseases who critically depend on these drugs. Efflux transporters may also influence brain elimination of Aβ, the hallmark of Alzheimer’s disease (AD). Impaired multidrug transporter function with reduced clearance of Aβ could lead to accumulation within the extracellular space, contributing to the pathogenesis of AD. We will determine the contribution of multidrug transporters to impaired brain uptake of drugs for the prediction of therapeutic responses, or the contribution of impaired transporter function to reduced clearance of toxic substances for the early in-vivo diagnosis of AD. Circumvention of pharmacoresistance, or increasing clearance, may involve inhibitors of multidrug transporters or sophisticated alternative therapies, but demonstration of overexpression or underactivity of transporter function is an essential and necessary first step. An in-vivo imaging biomarker of multidrug transporter function is essential for identifying altered transporter activity in individual patients. If a relation between overexpression and therapy resistance, or underactivity and AD, can be demonstrated, such a biomarker will provide the means for predicting treatment response, or early diagnosis, in individual patients.'

Altri progetti dello stesso programma (FP7-HEALTH)

PREDICT (2008)

Increasing the PaRticipation of the ElDerly in Clinical Trials

Read More  

GENEGRAFT (2011)

Phase I/II ex vivo gene therapy clinical trial for recessive dystrophic epidermolysis bullosa using skin equivalent grafts genetically corrected with a COL7A1-encoding SIN retroviral vector

Read More  

ATPBONE (2008)

Fighting osteoporosis by blocking nucleotides: purinergic signalling in bone formation and homeostasis

Read More