LIPIDIDIET

"THERAPEUTIC AND PREVENTIVE IMPACT OF NUTRITIONAL LIPIDS ON NEURONAL AND COGNITIVE PERFORMANCE IN AGING, ALZHEIMER’S DISEASE AND VASCULAR DEMENTIA"

 Coordinatore UNIVERSITAET DES SAARLANDES 

 Organization address address: CAMPUS
city: SAARBRUECKEN
postcode: 66041

contact info
Titolo: Ms.
Nome: Claudia
Cognome: Giehl
Email: send email
Telefono: +49 681 95923378
Fax: +49 681 95923370

 Nazionalità Coordinatore Germany [DE]
 Sito del progetto http://www.lipididiet.progressima.eu/
 Totale costo 7˙995˙577 €
 EC contributo 5˙899˙843 €
 Programma FP7-KBBE
Specific Programme "Cooperation": Food, Agriculture and Biotechnology
 Code Call FP7-KBBE-2007-1
 Funding Scheme CP-IP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-08-01   -   2015-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITAET DES SAARLANDES

 Organization address address: CAMPUS
city: SAARBRUECKEN
postcode: 66041

contact info
Titolo: Ms.
Nome: Claudia
Cognome: Giehl
Email: send email
Telefono: +49 681 95923378
Fax: +49 681 95923370

DE (SAARBRUECKEN) coordinator 0.00
2    Nome Ente NON disponibile

 Organization address address: YLIOPISTONRANTA 1 E
city: Kuopio
postcode: 70211

contact info
Titolo: Dr.
Nome: Heikki
Cognome: Tanila
Email: send email
Telefono: +358 40 3552084
Fax: +358 17 163030

FI (Kuopio) participant 0.00
3    DANONE RESEARCH BV

 Organization address address: Bosrandweg 20
city: UTRECHT
postcode: 6700 CA

contact info
Nome: J.H.P.
Cognome: Kersten
Email: send email
Telefono: +31 317 467804
Fax: +31 317 466 500

NL (UTRECHT) participant 0.00
4    EBERHARD KARLS UNIVERSITAET TUEBINGEN

 Organization address address: GESCHWISTER-SCHOLL-PLATZ
city: TUEBINGEN
postcode: 72074

contact info
Titolo: Dr.
Nome: Thomas
Cognome: Leyhe
Email: send email
Telefono: +49 7071 29 86 130
Fax: +49 7071 29 4141

DE (TUEBINGEN) participant 0.00
5    EUROPEAN RESEARCH AND PROJECT OFFICE GMBH

 Organization address address: Science Park 1, Stuhlsatzenhausweg 69
city: SAARBRUECKEN
postcode: 66123

contact info
Titolo: Mrs.
Nome: Claudia
Cognome: Giehl
Email: send email
Telefono: +49 681 95923 378
Fax: +49 681 95923 370

DE (SAARBRUECKEN) participant 0.00
6    FYZIOLOGICKY USTAV AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE (VVI)

 Organization address address: VIDENSKA 1083
city: PRAHA 4
postcode: 142 20

contact info
Titolo: Dr.
Nome: Vladimír
Cognome: Doležal
Email: send email
Telefono: +420 296 442287
Fax: +420 296 442488

CZ (PRAHA 4) participant 0.00
7    GOETEBORGS UNIVERSITET

 Organization address address: VASAPARKEN
city: GOETEBORG
postcode: 405 30

contact info
Titolo: Dr.
Nome: Margareta
Cognome: Ahlqwist
Email: send email
Telefono: +46 31 786 5345
Fax: +46 31 786 4355

SE (GOETEBORG) participant 0.00
8    KAROLINSKA INSTITUTET

 Organization address address: Nobels Vag 5
city: STOCKHOLM
postcode: 17177

contact info
Titolo: Mr.
Nome: Ulf
Cognome: Edin
Email: send email
Telefono: +46 858 587604
Fax: +46 858 586865

SE (STOCKHOLM) participant 0.00
9    KLINIKUM DER UNIVERSITAET REGENSBURG

 Organization address address: FRANZ JOSEF STRAUSS ALLEE 11
city: REGENSBURG
postcode: 93053

contact info
Titolo: Ms.
Nome: Elisabeth
Cognome: Geiger
Email: send email
Telefono: +49 941 944 5785
Fax: +49 941 944 5899

DE (REGENSBURG) participant 0.00
10    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539

contact info
Titolo: Ms.
Nome: Kerstin
Cognome: Fischer
Email: send email
Telefono: +49 89 5160 8340
Fax: +49 89 5160 8338

DE (MUENCHEN) participant 0.00
11    RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN

 Organization address address: REGINA PACIS WEG 3
city: BONN
postcode: 53113

contact info
Titolo: Ms.
Nome: Beate
Cognome: Gieselmann
Email: send email
Telefono: +49 228 287 19454
Fax: +49 228 287 14635

DE (BONN) participant 0.00
12    STICHTING KATHOLIEKE UNIVERSITEIT

 Organization address address: GEERT GROOTEPLEIN NOORD 9
city: NIJMEGEN
postcode: 6525 EZ

contact info
Titolo: Mr.
Nome: Fons
Cognome: Verstralen
Email: send email
Telefono: +31 24 3616336
Fax: +31 24 3610191

NL (NIJMEGEN) participant 0.00
13    STICHTING VU-VUMC

 Organization address address: DE BOELELAAN 1105
city: AMSTERDAM
postcode: 1081 HV

contact info
Titolo: Prof.
Nome: Philip
Cognome: Scheltens
Email: send email
Telefono: 31204440816

NL (AMSTERDAM) participant 0.00
14    SZEGEDI TUDOMANYEGYETEM

 Organization address address: DUGONICS TER 13
city: SZEGED
postcode: 6720

contact info
Titolo: Prof.
Nome: Botond
Cognome: Penke
Email: send email
Telefono: +36 62 545135
Fax: +36 62 545971

HU (SZEGED) participant 0.00
15    TEL AVIV UNIVERSITY

 Organization address address: RAMAT AVIV
city: TEL AVIV
postcode: 69978

contact info
Titolo: Ms.
Nome: Lea
Cognome: Pais
Email: send email
Telefono: +972 3 6408774
Fax: +972 3 6409697

IL (TEL AVIV) participant 0.00
16    UNIVERSITAETSKLINIKUM AACHEN

 Organization address address: Pauwelsstrasse 30
city: AACHEN
postcode: 52074

contact info
Titolo: Mr.
Nome: Volker
Cognome: Legewie
Email: send email
Telefono: +49 241 808 8494
Fax: +49 241 808 2051

DE (AACHEN) participant 0.00
17    UNIVERSITAETSKLINIKUM HEIDELBERG

 Organization address address: IM NEUENHEIMER FELD 672
city: HEIDELBERG
postcode: 69120

contact info
Titolo: Mr.
Nome: Thorsten
Cognome: Brietz
Email: send email
Telefono: +49 6221 56 7086
Fax: +49 6221 56 5460

DE (HEIDELBERG) participant 0.00
18    VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG

 Organization address address: De Boelelaan 1105
city: AMSTERDAM
postcode: 1081 HV

contact info
Titolo: Prof.
Nome: Philip
Cognome: Scheltens
Email: send email
Telefono: +31 204 440742
Fax: +31 204 440715

NL (AMSTERDAM) participant 0.00
19    ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT

 Organization address address: Square J 5
city: MANNHEIM
postcode: 68159

contact info
Nome: Simone
Cognome: Fuchs
Email: send email
Telefono: +49 621 1703 1321
Fax: +49 621 1703 2915

DE (MANNHEIM) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

suitable    perspective    health    reduce    preventing    molecules    supplementation    nutrition    consumed    related    evidence    dementia    overlap    age    dietary    prevent    lipids    designed    too    progressed    diseases    disease    lipididiet    effect    treatment    trial    population    belong    onset    ageing    amounts    specifically    pathological    diet    class    elderly    closely    cognitive    undetected    identical    stage    benefit    vascular    alzheimer    lipid    risk    first    recommended    performance    intervention    human    clinical    prevention   

 Obiettivo del progetto (Objective)

'Major objective: It is our aim to develop a lipid based diet that is able to delay or prevent onset of Alzheimer’s disease and related diseases and has a stabilizing effect on cognitive performance in aging. Multiple lines of evidence suggest that there is a large overlap between risk factor of these three diseases. Importantly, there is equally strong evidence that prevention and treatment of these diseases can be efficiently addresses - especially in their first and their priclinical stages - by closely related or identical bio-molecules. Predominantly these molecules appear to belong to the class of lipids which are part of the human diet. However, very often they are consumed in far lesser than recommended amounts. Bearing in mind that all of these diseases have a long pre-clinical phase in which the disease remains undetected specifically designed nutrition may be requirred for effective prevention or for those who already progressed into the first clinical stage of the disease. Moreover, frequently the within the elderly population pathological changes by two or all of these diseases occur in combination thus targeting only one would be insufficient. Taking these aspects into consideration, dietary supplementation, composed to maximize benefit for all three of these in the elderly common diseases, appears to be the most suitable approach to provide a general health perspective improvement for this age group in the EU population.'

Introduzione (Teaser)

The EU-funded LIPIDIDIET project aimed to develop a lipid-based diet capable of delaying or preventing the onset of Alzheimer's disease and vascular dementia. Such a diet would have a stabilising effect on neuronal and cognitive performance in ageing.

Descrizione progetto (Article)

Research and scientific evidence point to a large overlap between the risk factors of these and other related diseases, and indicates that they may be treated and prevented by leveraging the potential of closely related or identical biomolecules. These molecules are thought to belong to the class of lipids that are part of the human diet, but which are all too often consumed in less-than-recommended amounts.

Given that these diseases have a long preclinical phase during which the disease remains undetected, specifically designed nutrition may help prevent further progression. It may also prove useful for those who have already progressed into the first clinical stage.

Dietary supplementation, composed to maximise benefit for pathological changes related to ageing, is thus slated as the most suitable approach for improving on the general health perspective of Europe's elderly population.

Project members have produced a lipid-based diet for the treatment of volunteers in a double-blinded clinical trial, although it is still too early to assess the treatment's effect. However, in all parameters analysed thus far, the trial is performing as expected or better than expected. The parameters include safety/adverse side-effects, compliance, and drop-out rates and variance.

Clinical data based on the study participants reveal that diet-based early intervention significantly increases memory performance. As such, http://www.lipididiet.eu/ (LIPIDIDIET) researchers generally assume that earlier intervention would boost results even further.

To date, they have identified or further detailed dietary, lifestyle and genetic risk factors, as well as combinations of these factors that correlate with a decreased or increased risk for dementia. The researchers have studied the role of neurotransmission and identified novel mechanisms relating to how the dementia-causing amyloid molecules interfere with synaptic transmission, cellular differentiation and function. Progress has also been made on better understanding how dietary lipids might reduce this interference.

LIPIDIDIET results have already contributed to the development of dietary approaches and formulations that aim to more effectively reduce the risk for age-related cognitive decline. Continuing research and empirical study efforts thus offer great possibilities for future approaches to preventing and arresting the development of diseases like Alzheimer's and vascular dementia.

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