AEROPATH

"The identification, characterisation and exploitation of novel Gram-negative drug targets."

Coordinatore	UNIVERSITY OF DUNDEE    more  Organization address address: Nethergate city: DUNDEE postcode: DD1 4HN contact info Titolo: Ms. Nome: Zoe Cognome: Kidd Email: send email Telefono: +44(0)1382 384047 Fax: +44(0)1382 385438
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	6˙049˙979 €
EC contributo	4˙591˙463 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-B
Funding Scheme	CP-FP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-11-01   -   2012-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITY OF DUNDEE  Organization address address: Nethergate city: DUNDEE postcode: DD1 4HN contact info Titolo: Ms. Nome: Zoe Cognome: Kidd Email: send email Telefono: +44(0)1382 384047 Fax: +44(0)1382 385438	UK (DUNDEE)	coordinator	0.00
2	KAROLINSKA INSTITUTET  Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 contact info Titolo: Ms. Nome: Jill Cognome: Blomstrand Email: send email Telefono: +46 (0)8 52487687 Fax: +46 (0)8 304452	SE (STOCKHOLM)	participant	0.00
3	LIONEX GMBH  Organization address address: Salzdahlumer Strasse 196 city: BRAUNSCHWEIG postcode: 38126 contact info Titolo: Prof. Nome: Mahavir Cognome: Singh Email: send email Telefono: 495313000000 Fax: 495313000000	DE (BRAUNSCHWEIG)	participant	0.00
4	Mfd-diagnostics GmbH  Organization address address: Mikroforum Ring 2 city: Wendelsheim postcode: 55234 contact info Titolo: Dr. Nome: Bernd Cognome: Lecher Email: send email Telefono: 0049-6734-911200 Fax: 0049-6734-911222	DE (Wendelsheim)	participant	0.00
5	THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS  Organization address address: NORTH STREET 66 COLLEGE GATE city: ST ANDREWS FIFE postcode: KY16 9AJ contact info Titolo: Ms. Nome: Fiona Cognome: Thomson Email: send email Telefono: +44(0)1334 462215 Fax: +44(0)1334 462217	UK (ST ANDREWS FIFE)	participant	0.00

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 Obiettivo del progetto (Objective)

'An ambitious long-term programme of multidisciplinary research with two closely linked objectives is proposed to support antimicrobial drug development. Firstly, to advance understanding, at the molecular level, of fundamental and important aspects of the biology of Gram-negative bacteria using the important pathogen model Pseudomonas aeruginosa. Secondly, and most important, to exploit our discoveries and develop ligands and inhibitors (hit and lead compounds) with the potential to underpin the discovery of improved therapies for Gram-negative infections. The research covers five distinct areas, or work packages. (WPI) The experimental validation and therefore identification of novel targets by gene knockout in P. aeruginosa. (WPII) Cloning, characterisation, biochemical and structural biology, of the novel targets. (WPIII) A directed, search for ligands/inhibitors, exploiting data from WPI and WPII, for these validated antimicrobial drug targets by virtual screening (VS) and assessment of druggabilty, high-throughput screening (HTS) of a carefully prioritised subset of targets. (WPIV) The characterisation of the interactions formed between the drug target and the ligand/inhibitor by biochemical and crystallographic study, computational modelling and then design and modelling to enhance binding properties. (WPV) The initial biological testing for efficacy against Gram-negative bacteria.'