NANOTRYP

Exploiting Nanobodies in development of new diagnostic tools and treatment methods for Trypanosomiasis

Coordinatore	VIB    more  Organization address address: Rijvisschestraat 120 city: ZWIJNAARDE - GENT postcode: 9052 contact info Titolo: Mr. Nome: Rik Cognome: Audenaert Email: send email Telefono: +32 9 2446611 Fax: +32 9 2446610
Nazionalità Coordinatore	Belgium [BE]
Totale costo	3˙407˙256 €
EC contributo	2˙714˙608 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-B
Funding Scheme	CP-SICA
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-01-01   -   2013-06-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	VIB  Organization address address: Rijvisschestraat 120 city: ZWIJNAARDE - GENT postcode: 9052 contact info Titolo: Mr. Nome: Rik Cognome: Audenaert Email: send email Telefono: +32 9 2446611 Fax: +32 9 2446610	BE (ZWIJNAARDE - GENT)	coordinator	859˙320.00
2	FUNDACION PARA LA INVESTIGACION BIOSANITARIA DE ANDALUCIA ORIENTAL-ALEJANDRO OTERO  Organization address address: AVD. FUERZAS ARMADAS 2 city: GRANADA postcode: 18014 contact info Titolo: Ms. Nome: Biel Cognome: Sarah Email: send email Telefono: 34958020245 Fax: 34958020183	ES (GRANADA)	participant	586˙944.00
3	NATIONAL MUSEUMS OF KENYA*INSTITUTE OF PRIMATE RESEARCH  Organization address address: POBOX 24481 city: Nairobi postcode: 502 contact info Titolo: Dr. Nome: Maina Joseph Cognome: Ngotho Email: send email Telefono: +254 020 88 2571-4 Fax: +254 020 88 2546	KE (Nairobi)	participant	405˙424.00
4	UNIVERSIDADE EDUARDO MONDLANE  Organization address address: "Reitoria Da Universidade, Praca 25 De Junho 257" city: MAPUTO postcode: 200 contact info Titolo: Dr. Nome: Luis Cognome: Neves Email: send email Telefono: 258825000000 Fax: -25821475063	MZ (MAPUTO)	participant	374˙424.00
5	FOUNDATION FOR INNOVATIVE NEW DIAGNOSTICS  Organization address address: Avenue Louis-Casai 71 city: COINTRIN GENEVE postcode: 1216 contact info Titolo: Mr. Nome: Herbert Cognome: Clemens Email: send email Telefono: -1281 Fax: -1290	CH (COINTRIN GENEVE)	participant	283˙296.00
6	ARTTIC IN BRUSSELS SPRL  Organization address address: RUE DE LIVOURNE 7 bte 4 city: BRUXELLES postcode: 1060 contact info Titolo: Mr. Nome: Paul Cognome: Crompton Email: send email Telefono: +32 2 672 3339 Fax: +32 2 672 1646	BE (BRUXELLES)	participant	205˙200.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'African trypanosomiasis is in need of new diagnostic detection tools and new treatment methods. To date the widely used card agglutination test for trypanosomiasis is not very specific as the test is based on the screening for cross-reactive host antibodies. The availability of treatment for Trypanosmiasis on the other hand is limited due to the fact that only very few drugs are registered for use, and all can cause serious side effects in treated patients or animals. Hence, this project will focus on the development of new and innovative diagnosis and treatment tools, using the nanobody technology that has been developed by the coordinating partner of this network. Nanobodies are small single domain antibody fragments that have unique properties that include their capacity to recognize particular epitopes (not recognized by conventional antibodies) and their improved stability. In addition, they can be used as molecular target- or transport devices of other biological active components. As such they are excellent tools to support this project. Despite the fact that the coordinating laboratory has been a pioneer in differential molecular characterization of African trypanosomes and were involved in the initial release of diagnostic PCR methods that have now been adopted by many other research groups, this project will deliberately adopt a different approach. Indeed, in comparison to nanobody technology, PCR based diagnostics are much more costly and require an infrastructure that is hard to sustain over prolonged periods of time in African ‘field situations’. The simplicity of the nanobody technology on the other hand makes it an excellent topic for knowledge transfer. Despite it’s high-technology approach, the technique it will be relatively easy to be adopted by laboratories of participating African partner groups.'

Introduzione (Teaser)

Researchers from all over the world engaged in activities towards the development of novel diagnostic tools against trypanosomiasis. The deliverables of the NANOTRYP study could alleviate the heavy socioeconomic burden of endemic countries.