ANOPOPAGE

Population age structure and age structure modification via Wolbachia in Anopheles gambiae

 Coordinatore THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

 Organization address address: University Offices, Wellington Square
city: OXFORD
postcode: OX1 2JD

contact info
Titolo: Prof.
Nome: Stephen
Cognome: Conway
Email: send email
Telefono: +44 1865 270043

 Nazionalità Coordinatore United Kingdom [UK]
 Sito del progetto http://cordis.europa.eu/projects/223241
 Totale costo 1˙355˙286 €
 EC contributo 1˙000˙000 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-B
 Funding Scheme CP-FP
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-02-01   -   2012-07-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

 Organization address address: University Offices, Wellington Square
city: OXFORD
postcode: OX1 2JD

contact info
Titolo: Prof.
Nome: Stephen
Cognome: Conway
Email: send email
Telefono: +44 1865 270043

UK (OXFORD) coordinator 540˙203.80
2    CENTRE NATIONAL DE RECHERCHE SCIENTIFIQUE ET TECHNOLOGIQUE*INSTITUT DE RECHERCHE EN SCIENCES DE LA SANTE

 Organization address address: B P 7047
city: OUAGADOUGOU
postcode: 3

contact info
Titolo: Mr.
Nome: Levy
Cognome: Kaboré
Email: send email
Telefono: +226 20 974868
Fax: +226 20 974868

BF (OUAGADOUGOU) participant 183˙512.00
3    ARISTOTELIO PANEPISTIMIO THESSALONIKIS

 Organization address address: Administration Building, University Campus
city: THESSALONIKI
postcode: 54124

contact info
Titolo: Ms.
Nome: Christina
Cognome: Besta
Email: send email
Telefono: +30 2310 996745
Fax: +30 2310 853283

EL (THESSALONIKI) participant 165˙600.00
4    International Centre of Insect Physiology and Ecology

 Organization address address: "Off Thika Road, Duduville Campus"
city: Nairobi
postcode: 100

contact info
Titolo: Mr.
Nome: Roger
Cognome: Finan
Email: send email
Telefono: +254 20 8561171
Fax: +254 20 8632001

KE (Nairobi) participant 57˙928.16
5    INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT

 Organization address address: Boulevard de Dunkerque - CS 90009 44
city: MARSEILLE
postcode: 13572

contact info
Titolo: Ms.
Nome: Ariel
Cognome: Crozon
Email: send email
Telefono: 33148037721
Fax: 33140362385

FR (MARSEILLE) participant 52˙756.00
6    THE UNIVERSITY OF QUEENSLAND

 Organization address address: ST LUCIA
city: BRISBANE
postcode: 4072

contact info
Titolo: Ms.
Nome: Nicole
Cognome: Thompson
Email: send email
Telefono: 61733653560
Fax: 61733654455

AU (BRISBANE) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

transmission    greenhouse    adult    gambiae    wolbachia    population    malaria    mosquitoes    molecular    wmelpop    estimation    age    then    mosquito    lifespan    structure   

 Obiettivo del progetto (Objective)

'One of the most critical factors contributing to the vectorial capacity of malaria vector mosquitoes is the mean age attained by adult females, because after picking up the Plasmodium parasite there is a lengthy incubation period before transmission can occur. A virulent strain of the endosymbiotic bacterium Wolbachia called wMelPop reduces adult lifespan in its native Drosophila host, and has recently been shown to do the same following transfer into Aedes mosquitoes. We will examine its potential as a novel malaria control tool by creating and characterizing Anopheles cell lines containing wMelPop, and purifying and transferring it into An. gambiae by microinjection. We will then characterize the cytoplasmic incompatibility phenotype by which Wolbachia spreads itself, virulence (lifespan shortening effects), maternal transmission rates, and tissue distribution of introduced Wolbachia, together with analyses of mosquito gene expression using microarrays. Development of a molecular age estimation assay for the An. gambiae complex will be undertaken by adapting a new quantitative RT-PCR method for use in An. gambiae. We will then set up a greenhouse population of a member of the An. gambiae complex in Kenya that is viable over multiple generations, release marked mosquitoes to calibrate the molecular age estimation assays under semi-field conditions, and compare age structure between greenhouse and wild populations. In Burkina Faso we will estimate population age structure in the An. gambiae complex at 3 field sites, in different seasons and with / without insecticide treated net use. Liaison will take place with government institutions and local communities on regulatory issues and desirability of future Wolbachia-based trials in both countries. We will also build a suite of mathematical models to allow the analysis of different interventions that affect adult mosquito longevity, and incorporate the dynamics of Wolbachia spread in an age-structured population.'

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