EU-PACT

A pharmacogenomic approach to coumarin anticoagulant therapy

 Coordinatore UNIVERSITEIT UTRECHT 

 Organization address address: Heidelberglaan 8
city: UTRECHT
postcode: 3584 CS

contact info
Titolo: Ms.
Nome: Rinske
Cognome: De Kok-Baan
Email: send email
Telefono: +31 30 2538229
Fax: +31 30 2531645

 Nazionalità Coordinatore Netherlands [NL]
 Sito del progetto http://www.uu.nl/faculty/science/EN/organisation/depts/pharmaceuticalsciences/research/pp/projects/eupact/Pages/default.aspx
 Totale costo 3˙575˙385 €
 EC contributo 2˙544˙891 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-B
 Funding Scheme CP-FP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-10-01   -   2013-03-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    UNIVERSITEIT UTRECHT

 Organization address address: Heidelberglaan 8
city: UTRECHT
postcode: 3584 CS

contact info
Titolo: Ms.
Nome: Rinske
Cognome: De Kok-Baan
Email: send email
Telefono: +31 30 2538229
Fax: +31 30 2531645

NL (UTRECHT) coordinator 658˙185.00
2    THE UNIVERSITY OF LIVERPOOL

 Organization address address: Brownlow Hill, Foundation Building 765
city: LIVERPOOL
postcode: L69 7ZX

contact info
Titolo: Dr.
Nome: Jane
Cognome: Cloke
Email: send email
Telefono: +44 151 8726
Fax: +44 151 8728

UK (LIVERPOOL) participant 488˙072.00
3    UNIVERSITY OF NEWCASTLE UPON TYNE

 Organization address address: Kensington Terrace 6
city: NEWCASTLE UPON TYNE
postcode: NE1 7RU

contact info
Titolo: Ms.
Nome: Nicola
Cognome: Place
Email: send email
Telefono: +44 191 222 5324
Fax: +44 191 222 5920

UK (NEWCASTLE UPON TYNE) participant 388˙696.00
4    UPPSALA UNIVERSITET

 Organization address address: SANKT OLOFSGATAN 10 B
city: UPPSALA
postcode: 751 05

contact info
Titolo: Ms.
Nome: Anette
Cognome: Mc Loughlin
Email: send email
Telefono: +46 18 6112913
Fax: +46 18 509297

SE (UPPSALA) participant 309˙541.00
5    DEMOCRITUS UNIVERSITY OF THRACE

 Organization address address: PANEPISTIMIOUPOLI
city: KOMOTINI
postcode: 69100

contact info
Titolo: Prof.
Nome: Evangelos
Cognome: Manolopoulos
Email: send email
Telefono: +30 2551 030523
Fax: +30 2551 030523

EL (KOMOTINI) participant 224˙904.00
6    LGC LIMITED

 Organization address address: QUEENS ROAD
city: TEDDINGTON
postcode: TW11 0LY

contact info
Titolo: Dr.
Nome: Rita
Cognome: Barallon
Email: send email
Telefono: +44 0 208 943 7347
Fax: +44 0 208 943 8401

UK (TEDDINGTON) participant 161˙452.00
7    UNIVERSITAET ULM

 Organization address address: HELMHOLTZSTRASSE 16
city: ULM
postcode: 89081

contact info
Nome: Frank
Cognome: Gleixner
Email: send email
Telefono: +0049 731 500 66397
Fax: +0049 731 500 66392

DE (ULM) participant 154˙858.00
8    ACADEMISCH ZIEKENHUIS LEIDEN

 Organization address address: Albinusdreef 2
city: LEIDEN
postcode: 2333 ZA

contact info
Titolo: Ms.
Nome: Guillaine
Cognome: De Blecourt
Email: send email
Telefono: +31 715261629
Fax: +31 715266831

NL (LEIDEN) participant 73˙680.00
9    ALLGEMEIN OFFENTLICHES KRANKENHAUS DER ELISABETHINEN

 Organization address address: FADINGERSTRASSE 1
city: LINZ
postcode: 4010

contact info
Titolo: Mrs.
Nome: Elisabeth
Cognome: Haschke-Becher
Email: send email
Telefono: +43 0 73276763610
Fax: +43 0 73276763626

AT (LINZ) participant 54˙810.00
10    ERASMUS UNIVERSITEIT ROTTERDAM

 Organization address address: BURGEMEESTER OUDLAAN 50
city: ROTTERDAM
postcode: 3062 PA

contact info
Titolo: Mr.
Nome: Robert
Cognome: Speek
Email: send email
Telefono: 31104088849

NL (ROTTERDAM) participant 19˙182.90
11    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

 Organization address address: 's Gravendijkwal 230
city: ROTTERDAM
postcode: 3015CE

contact info
Titolo: Ms.
Nome: Jenny
Cognome: Klomps
Email: send email
Telefono: +31 10 4088529
Fax: +31 10 4089081

NL (ROTTERDAM) participant 11˙510.10
12    UNIVERSITE PARIS-SUD

 Organization address address: RUE GEORGES CLEMENCEAU 15
city: ORSAY
postcode: 91405

contact info
Titolo: Prof.
Nome: Laurent
Cognome: Becquemont
Email: send email
Telefono: +33 1 45 21 35 77
Fax: +33 1 45 21 36 51

FR (ORSAY) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

patients    inr    bleedings    genes    treatment    therapeutic    coumarins    coumarin    genotype    algorithm    polymorphisms   

 Obiettivo del progetto (Objective)

'The effectiveness of treatment with oral anticoagulants in the prevention of thrombotic disorders is well established, but these drugs are potentially dangerous because of their narrow therapeutic index. In Europe three coumarins are used: warfarin, acenocoumarol, and phenprocoumon. Genetic factors that have been recently demonstrated to change the pharmacokinetics and pharmacodynamics of coumarins are the presence of polymorphisms in the genes encoding for CYP2C9 and VKOR (vitamin K epoxide reductase complex). Polymorphisms in these genes are associated with increased risk for severe overanticoagulation and bleedings. A clinical trial will be performed in seven European countries to determine whether knowledge of the genotype of patients at the start of coumarin treatment will increase the safety of use of these compounds and whether such gene testing is cost-effective. Patients will be randomized to receive treatment with a coumarin either dosed with an algorithm that does not include information on their genotype, or with an algorithm that does contain this information. The primary outcome will be time within therapeutic INR range. Secondary outcomes include INR>4 and bleedings.'

Altri progetti dello stesso programma (FP7-HEALTH)

EURODSD (2008)

Investigation of the molecular pathogenesis and pathophysiology of Disorders of Sex Development (DSD)

Read More  

IDEA (2010)

Dissecting the Immunological Interplay between Poverty Related Diseases and Helminth Infections: An African-European Research Initiative

Read More  

EUROBATS (2011)

Identifying biomarkers of ageing using whole transcriptomic sequencing

Read More