NANO-DYN-SYN

Nano-Scale Organization Dynamics and Functions of Synapses: from single molecule tracking to the physiopathology of excitatory synaptic transmission

 Coordinatore CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE 

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 Nazionalità Coordinatore France [FR]
 Totale costo 3˙100˙000 €
 EC contributo 3˙100˙000 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2008-AdG
 Funding Scheme ERC-AG
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-02-01   -   2014-01-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

 Organization address address: Rue Michel -Ange 3
city: PARIS
postcode: 75794

contact info
Titolo: Dr.
Nome: Daniel
Cognome: Choquet
Email: send email
Telefono: +33 5 57 57 40 80
Fax: + 33 5 57 57 40 82

FR (PARIS) hostInstitution 3˙100˙000.00
2    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

 Organization address address: Rue Michel -Ange 3
city: PARIS
postcode: 75794

contact info
Titolo: Mr.
Nome: Christophe
Cognome: Giraud
Email: send email
Telefono: +33 5 57 35 58 60
Fax: +33 5 57 35 58 01

FR (PARIS) hostInstitution 3˙100˙000.00

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synaptic    transmission    imaging    molecular    quantitative    dependent    biosensors    unprecedented    synapses    postsynaptic    signaling    microscopic    nano    trafficking    electron    light    receptor    plasticity    fast   

 Obiettivo del progetto (Objective)

'Synapses are arguably the most elaborate signaling machine of cells. This complex intercellular junction is specialized for rapid (millisecond) directional signaling. In addition, synapses change in response to patterns of neural activity and these changes can endure, modifying neuronal circuitry. These competing properties of persistence and plasticity must be encoded by the precise content and arrangement of molecules that comprise the presynaptic and postsynaptic specializations. The objective of this project is to uncover the internal organization and dynamics of the postsynaptic specialization at excitatory glutamatergic synapses of the mammalian brain at an unprecedented nano-scale resolution. For this aim, neurobiologists, physicists and chemists join forces in a team with proven track record of collaboration. We will combine cellular and molecular neurobiology approaches with development of novel optical technologies, biosensors and combined quantitative light and electron microscopic imaging techniques. This will provide a new level of analysis to the fundamental problem of molecular information storage. Photothermal imaging of nano-gold particles will allow unprecedented quantitative histochemistry and tracking of protein trafficking up to the level of intact tissue. Development of Cryo-Photoactivated Light Microscopy will allow the correlative localization of synaptic elements at the light and electron-microscopic level. Novel biosensors and chemical tools will be developed for the investigation of the dynamic macromolecular events underlying synaptic plasticity. We will identify new mechanisms that control fast synaptic transmission and its long term activity dependent modification. We will unravel how fast receptor diffusion controls frequency dependent synaptic transmission and how regulation of receptor trafficking participates in synaptic plasticity.'

Altri progetti dello stesso programma (FP7-IDEAS-ERC)

NOGORISE (2012)

The Nogo-A receptor complex after CNS injury and its role in the developing and adult nervous system

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QOM (2009)

Quantum Optomechanics: quantum foundations and quantum information on the micro- and nanoscale

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MEC (2014)

Macroscopic Entanglement in Crystals

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