RZZ

Structural and Functional Characterization of the RZZ Complex

Coordinatore	ISTITUTO EUROPEO DI ONCOLOGIA SRL    more  Organization address address: Via Filodrammatici 10 city: MILANO postcode: 20121 contact info Titolo: Mr. Nome: Ilaria Cognome: Foti Email: send email Telefono: -257489256 Fax: -294375952
Nazionalità Coordinatore	Italy [IT]
Totale costo	0 €
EC contributo	164˙208 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IEF-2008
Funding Scheme	MC-IEF
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-04-01   -   2011-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	ISTITUTO EUROPEO DI ONCOLOGIA SRL  Organization address address: Via Filodrammatici 10 city: MILANO postcode: 20121 contact info Titolo: Mr. Nome: Ilaria Cognome: Foti Email: send email Telefono: -257489256 Fax: -294375952	IT (MILANO)	coordinator	164˙208.45

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 Obiettivo del progetto (Objective)

'This application is concerned with the structural and functional characterization of the RZZ protein complex, a critical constituent of metazoan kinetochores. The RZZ, a 400-kDa trimer, is named after the initials of its components, Rod, Zwilch and Zw10. The RZZ is implicated in the execution of mitosis, the process of equal partitioning of the genetic material. In mitosis, the sister chromatids attach to spindle microtubules and become aligned at the metaphase plate. This alignment process is orchestrated by the dynamic interaction of microtubules with kinetochores, the site of end-on attachment for microtubules to mitotic chromosomes. By recruiting the minus-end directed microtubule motor dynein, the RZZ complex contributes to form initial, lateral attachments of kinetochores to microtubules. The RZZ is also required for kinetochore recruitment of Mad1 and Mad2, two essential constituents of the spindle assembly checkpoint (SAC). Through biochemical reconstitution and structural methods, we will gain an understanding of the yet unknown organization of the RZZ. We will also develop biochemical assays to probe the interaction of the RZZ with defined kinetochore and SAC components, thus gaining an insight into the role of the RZZ in the larger framework of kinetochore organization and dynamics.'

Introduzione (Teaser)

Cellular mitosis is the process by which cells divide. It is critical to everyday tissue renewal and repair and is also involved in the uncontrolled cell division seen in cancer.