HELICAL TRANSPORTERS

AROMATIC FOLDAMERS AS DRUG DELIVERY CARRIERS

Coordinatore	UNIVERSITE BORDEAUX I    more  Organization address address: 351 Cours de la Liberation city: TALENCE postcode: 33405 contact info Titolo: Ms. Nome: Patricia Cognome: Dulor Email: send email Telefono: 33540006161 Fax: 33540002200
Nazionalità Coordinatore	France [FR]
Totale costo	0 €
EC contributo	164˙877 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IEF-2008
Funding Scheme	MC-IEF
Anno di inizio	2009
Periodo (anno-mese-giorno)	2009-04-01   -   2011-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITE BORDEAUX I  Organization address address: 351 Cours de la Liberation city: TALENCE postcode: 33405 contact info Titolo: Ms. Nome: Patricia Cognome: Dulor Email: send email Telefono: 33540006161 Fax: 33540002200	FR (TALENCE)	coordinator	164˙877.53

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 Obiettivo del progetto (Objective)

'The Huc group is a world leading research team in the fields of Biomimetic and Bioorganic Chemistry. One of group’s main contributions is focused on the synthesis, structural elucidation and biological application of aromatic oligoamides. These compounds adopt exceptionally stable folded conformations, helices, stabilised by intramolecular hydrogen bonds and - interactions. The high structural predictability, tunability, ease of synthesis and resistance to hydrolysis of such foldamers has led to an increasing attention towards those oligoamides. Very recently, Huc and co-workers have proven that despite the high hydrophobicity of those aromatic foldamers, they can be made highly hydrosoluble by inserting cationic side chains, providing important possibilities for their biological application as cell penetrating agents. This project focuses on the investigation of structural characteristics and the ability of aromatic oligoamides to cross the cellular membrane and deliver different cargoes efficiently. The qualitative and quantitative determination of uptake of the helices, intracellular trafficking and translocation of cargo will very importantly allow us to gain an insight into the kinetics and mechanism underlying the cellular translocation, areas that are currently being subject to a lot of controversy. The project is concerned with an emerging area of interdisciplinary chemical research in which the development of drug delivery technologies based on the new understanding of cross-membrane transport is expected to have a very strong impact on health and the design of novel therapeutic and diagnostic agents.'