SMART

Small Artery Remodelling

 Coordinatore LUNDS UNIVERSITET 

 Organization address address: Paradisgatan 5c
city: LUND
postcode: 22100

contact info
Titolo: Prof.
Nome: Per
Cognome: Hellstrand
Email: send email
Telefono: 46462229585
Fax: 46462224546

 Nazionalità Coordinatore Sweden [SE]
 Totale costo 3˙096˙503 €
 EC contributo 3˙096˙503 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-ITN-2008
 Funding Scheme MC-ITN
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-10-01   -   2013-09-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    LUNDS UNIVERSITET

 Organization address address: Paradisgatan 5c
city: LUND
postcode: 22100

contact info
Titolo: Prof.
Nome: Per
Cognome: Hellstrand
Email: send email
Telefono: 46462229585
Fax: 46462224546

SE (LUND) coordinator 656˙354.00
2    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539

contact info
Titolo: Prof.
Nome: Ulrich
Cognome: Pohl
Email: send email
Telefono: +49 89 2180 76501
Fax: +49 89 2180 76503

DE (MUENCHEN) participant 406˙239.00
3    WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

 Organization address address: SCHLOSSPLATZ 2
city: MUENSTER
postcode: 48149

contact info
Titolo: Mr.
Nome: Karl-Heinz
Cognome: Runde
Email: send email
Telefono: 492518000000
Fax: 492518000000

DE (MUENSTER) participant 398˙319.00
4    Academisch Medisch Centrum bij de Universiteit van Amsterdam

 Organization address address: MEIBERGDREEF 9
city: AMSTERDAM
postcode: 1105AZ

contact info
Titolo: Mr.
Nome: Huub
Cognome: Elstgeest
Email: send email
Telefono: 31205666264
Fax: 31206915462

NL (AMSTERDAM) participant 378˙318.00
5    NEUROSEARCH AS

 Organization address address: Pederstrupvej 93
city: BALLERUP
postcode: 2750

contact info
Titolo: Prof.
Nome: Soren-Peter
Cognome: Olesen
Email: send email
Telefono: 4544608777
Fax: 4544608080

DK (BALLERUP) participant 244˙653.00
6    AARHUS UNIVERSITET

 Organization address address: Nordre Ringgade 1
city: AARHUS C
postcode: 8000

contact info
Titolo: Ms.
Nome: Dorte
Cognome: Abildskov
Email: send email
Telefono: 4589422940
Fax: 4586129599

DK (AARHUS C) participant 239˙373.00
7    KING'S COLLEGE LONDON

 Organization address address: Strand
city: LONDON
postcode: WC2R 2LS

contact info
Titolo: Mr.
Nome: Paul
Cognome: Labbett
Email: send email
Telefono: 4402080000000
Fax: 4402080000000

UK (LONDON) participant 217˙332.00
8    UNIVERSITE DE FRIBOURG

 Organization address address: AVENUE DE L'EUROPE 20
city: FRIBOURG
postcode: 1700

contact info
Titolo: Ms.
Nome: Monique
Cognome: Bersier
Email: send email
Telefono: +41 26 300 70 03
Fax: +41 26 300 96 00

CH (FRIBOURG) participant 215˙364.00
9    UNIVERSITAETSKLINIKUM HEIDELBERG

 Organization address address: IM NEUENHEIMER FELD 672
city: HEIDELBERG
postcode: 69120

contact info
Titolo: Mr.
Nome: Thorsten
Cognome: Brietz
Email: send email
Telefono: 496222000000
Fax: 496222000000

DE (HEIDELBERG) participant 194˙703.00
10    PECSI TUDOMANYEGYETEM - UNIVERSITY OF PECS

 Organization address address: VASVARI PAL UTCA 4
city: PECS
postcode: 7622

contact info
Titolo: Prof.
Nome: ákos
Cognome: Koller
Email: send email
Telefono: +36 72 536 246
Fax: +36 72 536 247

HU (PECS) participant 145˙848.00
11    FONDATION DU CENTRE PLURIDISCIPLINAIRE D'ONCOLOGIE

 Organization address address: RUE DU BUGNON 46
city: LAUSANNE
postcode: 1011

contact info
Titolo: Ms.
Nome: Chantal
Cognome: Vonlanthen-Clerc
Email: send email
Telefono: -419
Fax: -549

CH (LAUSANNE) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

pressure    subjected    stress    interactions    wall    extracellular    composition    biology    cardiovascular    surrounding    shape    alterations    ecm    vessels    patients    shear    endothelial    signalling    hypertensive    arteries    specialized    undergo    size    cellular    differentiation    types    cells    cell    remodelling    interaction    small    blood    pathological    therapeutic    place    disease    vascular    ageing    smart    death    events    stimuli    mechanisms    diabetic    itn    artery    molecular    proteins    matrix    health    function   

 Obiettivo del progetto (Objective)

'Cardiovascular diseases are the leading cause of death and disability in the European population and represent a great burden of suffering and costs. Their complex etiology originates from different pathological stimuli and involves different cell types, resident in the vascular wall or infiltrating from the blood. The adaptation of the vasculature to physiological and pathophysiological forces depends on both the communication between its cellular components and their interaction with the extracellular matrix (ECM). When subjected to enhanced stretch, cyclic mechanical strain, or shear stress, blood vessels undergo typical transformations in wall shape that are always associated with alterations of the ECM and cellular composition, collectively described as vascular remodelling. Remodelling processes occur specifically in small arteries and arterioles, which show extreme changes in their size and function (microvascular remodelling). This is especially the case in hypertensive or diabetic patients, and contributes to a vicious cycle resulting in organ dysfunction and progression of vascular disease. A multidisciplinary approach is required to better understand vascular remodelling processes. We propose an interdisciplinary ITN to promote excellence in vascular biology, with focus on small vessels/arteries and their ECM. This will enhance the interaction between 8 academic groups and one SME in 7 European countries, specialized in physiology, signalling mechanisms, cell-cell and cell-matrix interactions in vascular endothelium and smooth muscle, as well as in drug discovery and development. The ITN will provide a specialized training ground by connecting investigations of the biology of vascular cells and their surrounding ECM in an innovative manner. It will therefore promote the careers of young investigators by specialising them in a field of vascular biology with a great potential for the future.'

Introduzione (Teaser)

Cardiovascular disease is a leading cause of death in Europe. Understanding the molecular and cellular events that drive vascular remodelling in health and disease would help identify novel therapeutic targets.

Descrizione progetto (Article)

Although the pathological stimuli may vary, arteries in cardiovascular disease are subjected to different types of stress such as elevated pressure. This causes them to undergo changes in wall shape as a result of alterations in the extracellular matrix and in the composition of vascular cells. This process is known as vascular remodelling. In diabetic or hypertensive individuals, it can lead to cardiovascular disease.

The expertise of the EU-funded 'Small artery remodelling' (http://www.smallartery.eu/ (SMART)) consortium focused on the biology of vascular cells and their surrounding extracellular matrix in health and disease. The main scientific objective was to elucidate the molecular mechanisms of cell-matrix and cell-cell interactions which take place during small artery remodelling. Small arteries branch out from the aorta and other arteries and are responsible for the oxygenation of all tissues in the body.

SMART researchers were interested to see how ageing and low oxygen supply can affect vascular remodelling. They discovered that hypoxia hampered artery formation and that ageing was associated with increased artery size and greater extracellular matrix composition. In addition, they looked at how the laminin family of basal membrane proteins affects the arterial response to shear and pressure.

They went on to further dissect the process of vascular remodelling with respect to the rearrangements that take place. They unravelled novel mechanisms regulating differentiation and growth of vascular cells and singled out key proteins.

Analysis of small artery remodelling in hypertensive rat models provided important insight about gene expression, artery structure and biomechanical properties, as well as endothelial function during disease.

Another key event in the remodelling process is the recruitment of stem cells to the damaged vessels. Scientists found that VEGF signalling regulated their differentiation into endothelial cells and identified microRNA-21 as the key regulator of this process.

The SMART study put together important pieces in the puzzle of vascular remodelling and identified several factors that could serve as potential therapeutic targets. This information could help reduce acute events such as stroke and myocardial infarction in vulnerable patients.

Altri progetti dello stesso programma (FP7-PEOPLE)

APPTOTAU (2015)

Elucidating pathways from hereditary Alzheimer mutations to pathological tau phenotypes

Read More  

RELATION WITH PAIN (2011)

Relationship with pain: Investigation of couple interaction in the maintenance of medically unexplained pain

Read More  

FUNGISORT (2014)

Sorting out host recognition of fungal infection

Read More