LIMB-TYPE ID

Identification of candidate limb type identity determining genes

Coordinatore	MEDICAL RESEARCH COUNCIL    more  Organization address address: NORTH STAR AVENUE POLARIS HOUSE city: SWINDON postcode: SN2 1FL contact info Titolo: Ms. Nome: Michele Cognome: Marron Email: send email Telefono: +44 208 816 2275 Fax: +44 208 959 4272
Nazionalità Coordinatore	United Kingdom [UK]
Totale costo	0 €
EC contributo	170˙733 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IEF-2008
Funding Scheme	MC-IEF
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-01-04   -   2012-01-03

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	MEDICAL RESEARCH COUNCIL  Organization address address: NORTH STAR AVENUE POLARIS HOUSE city: SWINDON postcode: SN2 1FL contact info Titolo: Ms. Nome: Michele Cognome: Marron Email: send email Telefono: +44 208 816 2275 Fax: +44 208 959 4272	UK (SWINDON)	coordinator	170˙733.61

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 Obiettivo del progetto (Objective)

'Vertebrates have two pairs homologous of appendages, the forelimbs and the hindlimbs. Although these appendages are morphologically distinct, it appears that the genetic networks controlling their development act equivalently in both appendages. While the mechanisms that initiate limb outgrowth and its polarity establishment are reasonably well understood, much less is known about genes regulating limb identity specification. A single gene, the transcription factor Pitx1, has been clearly demonstrated to determine limb-type identity in mouse. Therefore, the transcriptional targets of Pitx1 are excellent candidates to be key of the genetic network leading limb identity determination. By combining mouse molecular genetic methods and microarray screening technologies, I aim to identify novel players of limb-identity determination. We propose to exploit Pitx1 null mouse to undertake a DNA microarray screen. The resulting candidate genes will then be verified, characterised and functionally assessed by complementary approaches using mouse and chick. This work will enhance our understanding of the genetics networks leading to limb-identity specification. More broadly, this project will increase our knowledge of how common signalling cascades acting in a population of progenitor cells are modulated to generate diverse structures.'