NEURO.GSK3

GSK-3 in neuronal plasticity and neurodegeneration: basic mechanisms and pre-clinical assessment

 Coordinatore KATHOLIEKE UNIVERSITEIT LEUVEN 

 Organization address address: Oude Markt 13
city: LEUVEN
postcode: 3000

contact info
Titolo: Ms.
Nome: Tine
Cognome: Heylen
Email: send email
Telefono: +32 16 326520
Fax: +32 16 326515

 Nazionalità Coordinatore Belgium [BE]
 Sito del progetto http://med.kuleuven.be/neurogsk3/gsk3.html
 Totale costo 5˙082˙027 €
 EC contributo 3˙573˙842 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2007-B
 Funding Scheme CP-FP
 Anno di inizio 2008
 Periodo (anno-mese-giorno) 2008-10-01   -   2011-12-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN

 Organization address address: Oude Markt 13
city: LEUVEN
postcode: 3000

contact info
Titolo: Ms.
Nome: Tine
Cognome: Heylen
Email: send email
Telefono: +32 16 326520
Fax: +32 16 326515

BE (LEUVEN) coordinator 0.00
2    INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY

 Organization address address: ks. Trojdena 4
city: Warsaw
postcode: 02-109

contact info
Titolo: Dr.
Nome: Urszula
Cognome: Wyrzykowska
Email: send email
Telefono: +48 22 5970713
Fax: +48 22 5970715

PL (Warsaw) participant 0.00
3    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

 Organization address address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539

contact info
Titolo: Prof.
Nome: Jochen
Cognome: Herms
Email: send email
Telefono: +49 89 21 80 78 010
Fax: +49 89 21 80 78 037

DE (MUENCHEN) participant 0.00
4    MEDICAL RESEARCH COUNCIL

 Organization address address: NORTH STAR AVENUE POLARIS HOUSE
city: SWINDON
postcode: SN2 1FL

contact info
Titolo: Ms.
Nome: Elizabeth
Cognome: Cutler
Email: send email
Telefono: + 44 (0) 1223402357
Fax: + 44 (0)1223 412 515

UK (SWINDON) participant 0.00
5    NOSCIRA SA

 Organization address address: Calle Jose Abascal 2
city: MADRID
postcode: 28003

contact info
Titolo: Ms.
Nome: Rebeca
Cognome: García
Email: send email
Telefono: +34 91 806 11 30
Fax: +34 91 803 46 60

ES (MADRID) participant 0.00
6    TECHNISCHE UNIVERSITAET DARMSTADT

 Organization address address: Karolinenplatz 5
city: DARMSTADT
postcode: 64289

contact info
Titolo: Prof.
Nome: Boris
Cognome: Schmidt
Email: send email
Telefono: +49 6151 16 30 75
Fax: +49 6151 163278

DE (DARMSTADT) participant 0.00
7    TEL AVIV UNIVERSITY

 Organization address address: RAMAT AVIV
city: TEL AVIV
postcode: 69978

contact info
Titolo: Ms.
Nome: Lea
Cognome: Pais
Email: send email
Telefono: +972 3 640 8774
Fax: +972 3 640 5483

IL (TEL AVIV) participant 0.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

normal    ageing    vivo    neuronal    validated    protein    inhibitors    synapses    brain    gsk    tau    ftd    plasticity    adult    functions    models    mouse    contributions    spines    ad    kinases   

 Obiettivo del progetto (Objective)

'Neuronal circuits in mammalian brain act predominantly via excitatory synapses on dendritic spines. Formation of new spines in adult brain constitutes the structural basis of neuronal plasticity. The underlying molecular mechanisms remain largely unknown but depend essentially on kinase-dependent signalling pathways. Final formation of synapses on spines depends on dynamic interactions of microtubuli and actin-filaments that are also controlled by kinases. Deterioration of these processes to different extents are thought to cause the cognitive decline in normal ageing as well in Alzheimer's disease (AD) and familial fronto-temporal dementia (FTD). Protein tau is a microtubule associated protein and GSK-3 kinases are proposed as the major tau-kinases in vivo. Their exact contributions remain to be functionally defined in vivo both in normal neuronal plasticity and in degeneration. We develop pre-clinical models for AD and FTD that have tauopathy in common as essential pathogenic component and will explore the GSK-3 kinases in vivo by manipulating their activity genetically, pharmacologically and biochemically. Inhibitors are wanted that are effective and specific and enter brain in vivo. This proposal engages in three activities: (i) elucidate physiological functions of GSK-3 kinases in synaptic plasticity in adult and ageing brain, and in degenerating brain; define fundamental neuron-specific functions of GSK-3 kinases in vivo in novel mouse models; define contributions of GSK-3 kinases to amyloid and to tau pathology, separately and combined in vivo in validated mouse models (ii) design novel inhibitors of GSK-3 kinases and alternative tools to inhibit GSK-3 activity in vivo (iii) test pharmacological and peptidometic inhibitors of GSK-3 in validated mouse models of neurodegeneration for their restorative potential; analyse their mode of action and their acute and chronic effects by multi-parametric analysis'

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