TRAPAMPAR

Role of lateral diffusion of AMPA Receptors in LTP

Coordinatore	UNIVERSITE VICTOR SEGALEN BORDEAUX II    more  Organization address address: RUE LEO SAIGNAT 146 city: BORDEAUX CEDEX postcode: 33076 contact info Titolo: Dr. Nome: Daniel Cognome: Choquet Email: send email Telefono: 33-5-57 57 40 90 Fax: 33-05 57 57 40 82
Nazionalità Coordinatore	France [FR]
Totale costo	0 €
EC contributo	167˙145 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-IIF-2008
Funding Scheme	MC-IIF
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-03-01   -   2012-02-29

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITE VICTOR SEGALEN BORDEAUX II  Organization address address: RUE LEO SAIGNAT 146 city: BORDEAUX CEDEX postcode: 33076 contact info Titolo: Dr. Nome: Daniel Cognome: Choquet Email: send email Telefono: 33-5-57 57 40 90 Fax: 33-05 57 57 40 82	FR (BORDEAUX CEDEX)	coordinator	167˙145.56

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 Obiettivo del progetto (Objective)

'Synaptic recruitment of AMPA receptors (AMPAR) is a critical step in synaptic plasticity events such as Long term potentiation (LTP). Although the signaling events necessary for the induction of LTP are well known (i.e. NMDA receptor activation and activation of protein kinase cascades), the source of the newly inserted AMPAR is still unclear. There are two pools of AMPA receptors that can be potentially mobilized to the synapse during LTP: a pool of AMPAR-containing intracellular vesicles and a pool of membrane-located extrasynaptic AMPAR. Since recent studies carried out mainly at the host laboratory have demonstrated that extrasynaptic AMPAR are highly mobile (sometimes moving in and out of synapses), it is possible that the increases in synaptic transmission observed during LTP might be due to the diffusional trapping of passing extrasynaptic AMPAR. During this project I will use a combination of state of the art imaging and electrophysiological approaches to test the hypothesis that mobile extrasynaptic AMPAR correspond to the most immediate source for the newly inserted AMPAR during LTP.'