Elucidation of MicroRNAs as Regulators of Metabolism and Targets for Therapeutic Intervention


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 Nazionalità Coordinatore Switzerland [CH]
 Totale costo 2˙021˙235 €
 EC contributo 2˙021˙235 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2009-AdG
 Funding Scheme ERC-AG
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-07-01   -   2015-06-30


# participant  country  role  EC contrib. [€] 

 Organization address address: Raemistrasse 101
postcode: 8092

contact info
Titolo: Prof.
Nome: Markus
Cognome: Stoffel
Email: send email
Telefono: +41 0 44 633 45 60

CH (ZUERICH) hostInstitution 2˙021˙235.00


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

regulation    rna    cells    play    cell    mirnas    obesity    mirna    metabolism    rnas    mechanisms    pathways    dissect    diabetes    addition    gene    networks    small    glucose    underlying    molecular    strategies    regulatory    expression   

 Obiettivo del progetto (Objective)

'Small RNA-mediated regulation of gene expression is a recent addition to fundamental gene regulatory mechanisms that directly or indirectly affect possibly every gene of a eukaryotic genome. The predominant sources of small RNA in somatic tissues are microRNA genes that encode short dsRNA hairpins of evolutionary conserved sequence. Disorders of metabolism, such as obesity and type 2 diabetes are poorly understood at a molecular level. In this application we propose to explore if miRNA regulatory networks play a role in these diseases. We will employ state of the art methods for identification of small RNAs and their regulated targets and use biochemical, cell and animal model systems to study the detailed molecular mechanisms of metabolic gene regulation by miRNAs. In addition, we will investigate the underlying principles of how RNAs are taken up by cells and develop methods that will improve delivery of miRNA mimetics or inhibitors through cell-specific uptake. The specific aims of this study are: Aim 1: To define the small regulatory miRNA content of liver, muscle and adipose tissue that are associated with abnormal glucose and lipid homeostasis and to dissect the underlying molecular pathways that govern their expression. Aim 2: To characterize the functions of miRNAs in insulin resistance, glucose uptake and production, fatty acid oxidation and lipogenesis. Aim 3: To identify factors and dissect the pathways that regulate RNA uptake by cells and to develop novel pharmacological treatment strategies to manipulate miRNA-expression. Together, this proposal will shed light on the function that miRNA regulatory networks play in metabolism and in the pathophysiology of obesity/type 2 diabetes. In addition, these studies will contribute to the development of new RNA delivery technologies that are urgently needed as experimental tools as well as for novel therapeutic strategies.'

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ERMITO (2012)

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