TERNANOMED

TERPENOYLATION: AN ORIGINAL CONCEPT FOR THE DISCOVERY OF NEW NANOMEDICINES

 Coordinatore UNIVERSITE PARIS-SUD 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore France [FR]
 Totale costo 2˙198˙799 €
 EC contributo 2˙198˙799 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2009-AdG
 Funding Scheme ERC-AG
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-06-01   -   2015-05-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    SOCIETE DE PHARMACOLOGIE ET D'IMMUNOLOGIE BIO SA

 Organization address city: Montigny le Bretonneux
postcode: 78180

contact info
Titolo: Mr.
Nome: Alain
Cognome: Champoudry
Email: send email
Telefono: +33 139306104
Fax: +33 139306155

FR (Montigny le Bretonneux) beneficiary 150˙000.00
2    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

 Organization address address: RUE LEBLANC 25
city: PARIS 15
postcode: 75015

contact info
Titolo: Ms.
Nome: Eliane
Cognome: Deck-Chaumont
Email: send email
Telefono: +33 1 69082009
Fax: +33 1 69083551

FR (PARIS 15) beneficiary 120˙000.00
3    UNIVERSITE CATHOLIQUE DE LOUVAIN

 Organization address address: Place De L'Universite 1
city: LOUVAIN LA NEUVE
postcode: 1348

contact info
Titolo: Ms.
Nome: Anne
Cognome: Bovy
Email: send email
Telefono: +32 10 47 3873
Fax: +32 10 47 48 30

BE (LOUVAIN LA NEUVE) beneficiary 12˙000.00
4    UNIVERSITE PARIS-SUD

 Organization address address: RUE GEORGES CLEMENCEAU 15
city: ORSAY
postcode: 91405

contact info
Titolo: Mr.
Nome: Nicolas
Cognome: Lecompte
Email: send email
Telefono: 33169155589
Fax: 33169155599

FR (ORSAY) hostInstitution 1˙916˙799.00
5    UNIVERSITE PARIS-SUD

 Organization address address: RUE GEORGES CLEMENCEAU 15
city: ORSAY
postcode: 91405

contact info
Titolo: Prof.
Nome: Patrick
Cognome: Couvreur
Email: send email
Telefono: (33) 1.46.83.53.96
Fax: (33) 1.46.61.93.34

FR (ORSAY) hostInstitution 1˙916˙799.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

natural    diseases    active    nanoassemblies    nature    cell    compounds    terpenoids    drug    molecule    nanomedicine    polyterpene    biologically    terpenoid   

 Obiettivo del progetto (Objective)

'Terpenoids are a group of natural compounds that are extraordinary diverse in chemistry, structure and function. Most of the natural terpenoids are flexible and biocompatible biopolymers, having physico-chemical characteristics able to adapt to a wide variety of biologically active compounds. Surprisingly, they have never been used previously in the nanotechnology field for drug delivery and targeting purposes, except very recently by us to design squalene-based nanoassemblies. Thus, the current project aims to develop terpenoid-based nanoassemblies to improve the treatment of severe diseases incl. cancer, infectious and metabolic diseases. The conceptual approach is to chemically link a terpenoid to a biologically active drug molecule in order to allow the resulting bioconjugate to self-assemble as nanoparticles in water. Noteworthy, the nature of the polyterpenoid (ie. number of isoprenoid units) may be adapted to the hydrophilic/lipophilic character of the drug molecule to be transported, whereas the nature of the linkage (ester, amide, disulfide bonds etc.) will be selected according to the enzymatic content of the targeted diseased area. From the ratio between drug s and polyterpene s molecular weights, it is deduced that the drug loading will be dramatically improved as compared to the currently available nanomedicines. In other words, the pro-drug will form the nanomedicine by selfaggregation without the need of any other transporter material. The project will involve the following interdisciplinary aspects:(i) synthesis of drug/polyterpene bioconjugates,(ii)design of the nanoassemblies and their functionalization with recognition ligands,(iii)cell and tissue imaging and(iv)pharmacological evaluation in vitro (cell culture) and in vivo. Such ambitious and challenging project will be performed under Patrick Couvreur s leadership who has settled up a worldwide recognized multidisciplinary research team, unique in the nanomedicine world.'

Altri progetti dello stesso programma (FP7-IDEAS-ERC)

ECOMAGICS (2012)

Electric Control of Magnetization Dynamics

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STRING-QCD-BH (2010)

"String Theory, QCD and Black Holes"

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Q-MAC (2013)

Frontiers in Quantum Materials Control

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