TOR-AA

Amino acid sensing by TOR

 Coordinatore DEUTSCHES KREBSFORSCHUNGSZENTRUM 

Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.

 Nazionalità Coordinatore Germany [DE]
 Totale costo 1˙499˙279 €
 EC contributo 1˙499˙279 €
 Programma FP7-IDEAS-ERC
Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call ERC-2010-StG_20091118
 Funding Scheme ERC-SG
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-09-01   -   2015-08-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    DEUTSCHES KREBSFORSCHUNGSZENTRUM

 Organization address address: Im Neuenheimer Feld 280
city: HEIDELBERG
postcode: 69120

contact info
Titolo: Dr.
Nome: Aurelio
Cognome: Teleman
Email: send email
Telefono: +49 6221 42 1620
Fax: +49 6221 42 1629

DE (HEIDELBERG) hostInstitution 1˙499˙279.20
2    DEUTSCHES KREBSFORSCHUNGSZENTRUM

 Organization address address: Im Neuenheimer Feld 280
city: HEIDELBERG
postcode: 69120

contact info
Titolo: Dr.
Nome: Ina
Cognome: Krischek
Email: send email
Telefono: 496221000000
Fax: 496221000000

DE (HEIDELBERG) hostInstitution 1˙499˙279.20

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

amino    acid    performed    genes    screen    regulate    disease    genome    acids    tor    cell    human    platform    resistance    pilot    lab   

 Obiettivo del progetto (Objective)

'The kinase TOR is a key regulator of cell growth and organismal metabolism in animals. Consequently, the correct regulation of TOR activity is important both for normal development and for disease. For instance, TOR is hyperactivated in almost all human cancers, and reduced TOR activity is associated with leanness and resistance to obesity. TOR activity is regulated by a number of inputs including, importantly, amino acids. Indeed, nutritional amino-acid overload in humans is thought to promote insulin resistance via TOR activation. However, the molecular mechanism by which amino acids regulate TOR is still mysterious. I propose here to identify and characterize factors required for amino acids to regulate TOR. We will use a genome-wide functional-genomics approach to systematically identify a large number of genes involved in this process, thereby hopefully making a significant contribution to the field. Identification of these novel factors may open avenues for diagnosis and treatment of cancer and metabolic disease. This project will exploit a high-throughput, cell-based screen for genes involved specifically in amino acid sensing by TOR which we have implemented in my lab. In collaboration with the neighboring Boutros lab, we have performed a pilot screen on the 780 kinases of the human genome, proving that the screen is working successfully, and yielding a number of interesting hits which we have validated. The PhD student in my lab who performed the pilot screen is now characterizing these new genes. I would like to fully exploit this platform by executing the screen on a genome-wide level, and following-up on the genes that will be discovered. However, I do not have the necessary resources to do so. An ERC starting grant would allow us to do this, leveraging our technology platform and the work we invested in creating it. I strongly believe these results will be exciting and of general interest, helping to establish me in the field.'

Altri progetti dello stesso programma (FP7-IDEAS-ERC)

FOLDHALO (2013)

Folding with Halogen Bonding

Read More  

KNOWING (2014)

Epistemic intersections in early modern England: the place of literature

Read More  

ISOSYC (2014)

Initial Solar System Composition and Early Planetary Differentiation

Read More