SUMOMAN

Supramolecular Cell Manipulation

Coordinatore	UNIVERSITEIT TWENTE    more Spiacenti, non ci sono informazioni su questo coordinatore. Contattare Fabio per maggiori infomrazioni, grazie.
Nazionalità Coordinatore	Netherlands [NL]
Totale costo	1˙500˙000 €
EC contributo	1˙500˙000 €
Programma	FP7-IDEAS-ERC Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	ERC-2010-StG_20091028
Funding Scheme	ERC-SG
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-11-01   -   2015-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITEIT TWENTE  Organization address address: DRIENERLOLAAN 5 city: ENSCHEDE postcode: 7522 NB contact info Titolo: Dr. Nome: Pascal Cognome: Jonkheijm Email: send email Telefono: +31 53 4892987 Fax: +31 53 4894645	NL (ENSCHEDE)	hostInstitution	1˙500˙000.00
2	UNIVERSITEIT TWENTE  Organization address address: DRIENERLOLAAN 5 city: ENSCHEDE postcode: 7522 NB contact info Titolo: Mr. Nome: Ferdinand Cognome: Damhuis Email: send email Telefono: +31 53 4894019 Fax: +31 53 4894841	NL (ENSCHEDE)	hostInstitution	1˙500˙000.00

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 Obiettivo del progetto (Objective)

'Supramolecular chemistry and nanofabrication methods provide excellent prospect to construct reversible dynamic biological nanoplatforms employed for supramolecular cell manipulation (SUMOMAN) experiments. Making use of supramolecular chemistry is a rewarding task in developing functional materials and devices. Knowing the limitations involved in ordering proteins at different length scales will surely hasten the development of future applications, supramolecular nanobiology being the most prominent. The construction of synthetic supramolecular assemblies of proteins provides an excellent tool to fabricate organized bioactive components in the sub-micron regime at surfaces. Supramolecular nanobiology narrows the gap between chemical biology and bionanotechnology. The latter devises ways to construct molecular devices using biomacromolecules and it attempts to build molecular machines utilizing concepts seen in nature. In chemical biology new synthesis methods and strategies are developed and employed for the synthesis of compounds which are used as probes for the study of biological phenomena. Steadily improved synthetic procedures for site-specific modification of proteins have gained more control over structure and function of the proteins. However, applications of protein chips remain hampered by orientational and conformational aspects at the surface. With the development of supramolecular bioactive nano-platforms on surfaces serving as a reversible dynamic interface to cells, the goal to study and manipulate cellular processes will come closer. An innovative construction process of biological nanoarrays is proposed to study important fundamental aspects of cell biology. When such structured surfaces display a biological interface with nm resolution, a lengthscale inherently more relevant to biorecognition than microlengthscales, the communication through biomolecules with cellular receptors can be modulated with unprecedented spatial and temporal specificity.'