ANGIOFISH

NEW MOLECULAR MECHANISMS INVOLVED IN VASCULAR MATURATION AND MYOGENESYS IN VERTEBRATE DEVELOPMENT

Coordinatore	UNIVERSITA DEGLI STUDI DI TORINO    more  Organization address address: Via Giuseppe Verdi 8 city: TORINO postcode: 10124 contact info Titolo: Prof. Nome: Lorenzo Cognome: Silengo Email: send email Telefono: +39 011 6706415 Fax: +39 011 6706432
Nazionalità Coordinatore	Italy [IT]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2009-RG
Funding Scheme	MC-IRG
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-11-01   -   2014-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITA DEGLI STUDI DI TORINO  Organization address address: Via Giuseppe Verdi 8 city: TORINO postcode: 10124 contact info Titolo: Prof. Nome: Lorenzo Cognome: Silengo Email: send email Telefono: +39 011 6706415 Fax: +39 011 6706432	IT (TORINO)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'The vascular system is the first organ to form and function during embryonic development. Its correct development is essential for the proper formation of vertebrate embryos as well as for adulthood. Although much attention has been focused on the genetic requirements for early vascular development (vasculogenesis), the mechanisms controlling later stages of blood vessel development (angiogenesis and vascular myogenesis) are largely unknown. In the past, we have successfully used the embryological and genetic attributes of the zebrafish model to study endothelial cell (EC) development: we identified regulators of blood vessel integrity and characterized vascular mural cells (MC). Here, we propose to identify new mechanisms involved in angiogenesis (formation of new vessels) and blood vessel myogenesis (maturation of vessels) focusing on the reciprocal relationship between EC and their surrounding microenvironment, including MC. Using a set of new cellular, molecular, and genetic approaches as well as advanced microscopy techniques, I propose to elucidate how endothelial and mural cells cooperate to shape the cardiovascular system and regulate vascular maturation and myogenesis. The long-term goal is to provide additional molecular entry points to further investigate EC maturation and MC development/differentiation in normal and pathological conditions using the zebrafish vertebrate system. To my knowledge this is a new research area in the cardiovascular field never investigate before.'