EDPAH

Mechanisms of Exertional Dyspnea in Patients with Idiopathic Pulmonary Arterial Hypertension

Coordinatore	UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6    more  Organization address address: Place Jussieu 4 city: PARIS postcode: 75252 contact info Titolo: Ms. Nome: Ella Cognome: Bouquet Email: send email Telefono: 33144279777 Fax: 33144277484
Nazionalità Coordinatore	France [FR]
Totale costo	50˙000 €
EC contributo	50˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-RG
Funding Scheme	MC-IRG
Anno di inizio	2010
Periodo (anno-mese-giorno)	2010-11-01   -   2012-10-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6  Organization address address: Place Jussieu 4 city: PARIS postcode: 75252 contact info Titolo: Ms. Nome: Ella Cognome: Bouquet Email: send email Telefono: 33144279777 Fax: 33144277484	FR (PARIS)	coordinator	50˙000.00

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 Obiettivo del progetto (Objective)

'Activity-related dyspnea appears to be the earliest and dominant symptom limiting exercise in the majority of patients afflicted by pulmonary arterial hypertension. This symptom progresses relentlessly with time leading invariably to avoidance of activity with consequent skeletal muscle deconditioning and poor perceived quality of life. Unfortunately, effective management of this disabling symptom awaits a better understanding of its underlying physiology. A growing body of evidence have highlighted that patients with pulmonary arterial hypertension may present with respiratory muscle weakness and abnormal lung function/respiratory mechanics. Despite these findings, to date little is known about the potential contribution of abnormalities in respiratory mechanics and ventilatory muscle function to dyspnea causation during physical exercise in patients with pulmonary arterial hypertension. This is, therefore, the main focus of the present study, with the aim of identifying potential unexplored physiological mechanisms that can be targeted for therapeutic manipulation.'