NIDIAG

Syndromic approach to Neglected Infectious Diseases (NID) at primary health care level: an international collaboration on integrated diagnostic-treatment platforms

 Coordinatore PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE 

 Organization address address: Nationalestraat 155
city: ANTWERPEN
postcode: 2000

contact info
Titolo: Ms.
Nome: Eva
Cognome: Mostmans
Email: send email
Telefono: +32 3 247 67 22
Fax: +32 3 247 67 22

 Nazionalità Coordinatore Belgium [BE]
 Totale costo 6˙446˙506 €
 EC contributo 5˙000˙000 €
 Programma FP7-HEALTH
Specific Programme "Cooperation": Health
 Code Call FP7-HEALTH-2010-single-stage
 Funding Scheme CP-FP-SICA
 Anno di inizio 2010
 Periodo (anno-mese-giorno) 2010-11-01   -   2016-04-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE

 Organization address address: Nationalestraat 155
city: ANTWERPEN
postcode: 2000

contact info
Titolo: Ms.
Nome: Eva
Cognome: Mostmans
Email: send email
Telefono: +32 3 247 67 22
Fax: +32 3 247 67 22

BE (ANTWERPEN) coordinator 1˙070˙522.60
2    LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE

 Organization address address: KEPPEL STREET
city: LONDON
postcode: WC1E7HT

contact info
Titolo: Ms.
Nome: Jana
Cognome: Sabinovska
Email: send email
Telefono: +44 20 7927 2509
Fax: +44 20 75805636

UK (LONDON) participant 676˙200.00
3    UNIVERSITE DE GENEVE

 Organization address address: Rue du General Dufour 24
city: GENEVE
postcode: 1211

contact info
Titolo: Dr.
Nome: Emilie
Cognome: Alirol
Email: send email
Telefono: +41 76 403 44 36
Fax: +41 22 372 96 26

CH (GENEVE) participant 532˙000.00
4    CORIS BIOCONCEPT SPRL

 Organization address address: RUE JEAN SONET 4A PARC SCIENTIFIQUE CREALYS LES ISNES
city: Gembloux
postcode: 5032

contact info
Titolo: Mr.
Nome: Marc
Cognome: Visser
Email: send email
Telefono: +32 81719916
Fax: +32 81719919

BE (Gembloux) participant 359˙000.00
5    BP KOIRALA INSTITUTE OF HEALTH SCIENCES

 Organization address address: Ghopa
city: DHARAN

contact info
Titolo: Mr.
Nome: Nand Kumar
Cognome: Thapa
Email: send email
Telefono: +977 25 520991
Fax: +977 25 531253

NP (DHARAN) participant 336˙000.00
6    SCHWEIZERISCHES TROPEN- UND PUBLIC HEALTH-INSTITUT

 Organization address address: SOCINSTRASSE 57
city: Basel
postcode: CH-4002

contact info
Titolo: Prof.
Nome: Jürg
Cognome: Utzinger
Email: send email
Telefono: +41 61 2848129
Fax: +41 61 2848101

CH (Basel) participant 295˙000.00
7    INSERM - TRANSFERT SA

 Organization address address: Rue Watt 7
city: PARIS
postcode: 75013

contact info
Titolo: Dr.
Nome: Natacha
Cognome: Edme
Email: send email
Telefono: +33 4 72 13 89 83
Fax: +33 1 55 03 01 60

FR (PARIS) participant 288˙329.00
8    GADJAH MADA UNIVERSITY

 Organization address address: BULAKSUMUR
city: YOGYAKARTA
postcode: 55281

contact info
Titolo: Ms.
Nome: Wenny
Cognome: Widyastuti
Email: send email
Telefono: +62 274 547147
Fax: +62 274 547147

ID (YOGYAKARTA) participant 287˙000.00
9    INSTITUT NATIONAL DE RECHERCHE EN SANTE PUBLIQUE INRSP

 Organization address address: Route de Koulikoro Avenue Amilcar Cabral 52
city: Bamako

contact info
Titolo: Dr.
Nome: Moussa
Cognome: Sacko
Email: send email
Telefono: +223 6690 3056
Fax: +223 2021 4320

ML (Bamako) participant 286˙463.90
10    University of Khartoum

 Organization address address: University of Khartoum
city: Khartoum
postcode: 11115

contact info
Titolo: Prof.
Nome: Sayda
Cognome: El Safi
Email: send email
Telefono: +249 183 77 50 72
Fax: +249 183 78 78 16

SD (Khartoum) participant 251˙329.70
11    INSTITUT NATIONAL DE RECHERCHE BIOMEDICALE DU ZAIRE

 Organization address address: AVENUE DE LA DEMOCRATIE
city: KINSHASA GOMBE
postcode: 1197

contact info
Titolo: Dr.
Nome: Franck
Cognome: Lionzo Bilebile
Email: send email
Telefono: +243 99 99 13 614
Fax: +243 99 99 13 614

CD (KINSHASA GOMBE) participant 242˙654.00
12    SITA RAM MEMORIAL TRUST

 Organization address address: "RAMBAG ROAD, SITA RAM MEMORIAL TRUST, UNIT KALA AZAR MEDICAL RESEARCH CENTRE"
city: MUZAFFARPUR
postcode: 842001

contact info
Titolo: Prof.
Nome: Shyam
Cognome: Sundar
Email: send email
Telefono: +91 542 2367795
Fax: +91 6212287570

IN (MUZAFFARPUR) participant 210˙000.00
13    Sihanouk Hospital Corporation

 Organization address address: W. Lancaster Ave 353
city: Wayne
postcode: 19087

contact info
Titolo: Ms.
Nome: Shelly
Cognome: Malhotra
Email: send email
Telefono: +855 099 276 208
Fax: +855 023 882 485

US (Wayne) participant 165˙500.80

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

diseases    tropical    south    receive    evaluation    treatment    persistent    digestive    health    trypanosomiasis    neglected    schistosomiasis    leishmaniasis    disease    related    epidemiological    latest    diagnostic    endemic    innovations    diagnostics    fever    quality    neurological    thereby    policy    evidence    diagnosis    primary    syndromes    nid    progression    dec    global    algorithms    platforms    africa    infectious    nidiag    asia    technological    morbidity    care    clinical    perform    rationalise    countries    mortality    tools   

 Obiettivo del progetto (Objective)

'Neglected Infectious Diseases (NID) such as trypanosomiasis, leishmaniasis, schistosomiasis and soil-transmitted helminthiasis receive less than 5% of the global investment for tropical diseases research. Clinical praxis in disease-endemic countries (DEC) is rarely evidence based and does not make use of the latest innovations in diagnostic technology. NID–related research on diagnostics is particularly underfunded, and diagnostic tools are lacking for a number of NID. The aim of this proposal is to bridge the gap between existing technological innovation in diagnostics and clinical care practice for NID in resource-poor settings. The specific objectives are to develop simple, cost-effective diagnosis-treatment algorithms for three NID-related clinical syndromes: the persistent fever, the neurological and the digestive syndromes. Evidence-based algorithms for the primary care level will be designed with a patient-centred approach, following guidance from DEC stakeholders and making the best possible use of existing assays and treatments. Relevant diagnostic technology and diagnostic platforms will be introduced according to the specific epidemiological contexts in Africa and South-Asia. The research consortium brings together a network of clinical epidemiologists, a diagnostics development group, several partners from academia and SMEs. The consortium further includes workpackages on reference laboratory, economic evaluation, quality assurance and translation to policy. By developing accurate and affordable diagnostic platforms and by optimizing diagnostic-treatment algorithms, this project will rationalise treatment use, circumvent progression to severe presentations and thereby reduce NID morbidity/mortality and hinder the emergence of resistances. The project will result in two main deliverables: policy recommendation for health authorities in DEC, and a series of innovative diagnostic platforms.'

Introduzione (Teaser)

A global front on the diagnosis and management of neglected infectious diseases (NID) should significantly improve their therapeutic decision-making.

Descrizione progetto (Article)

Tropical diseases such as trypanosomiasis, leishmaniasis and schistosomiasis receive minimal funding for research and thus fall under the category of neglected infectious diseases (NID). Clinical management and treatment of these diseases in endemic countries is not evidence-based and hardly utilises the latest technology.

The EU-funded NIDIAG (Syndromic approach to neglected infectious diseases (NID) at primary health care level: an international collaboration on integrated diagnostic-treatment platforms) project aims to introduce technological innovations in diagnostics for NID-related clinical care. The primary goal is to develop evidence-based algorithms for the treatment and diagnosis of the NID-related persistent fever, neurological and digestive syndromes. By bringing in experts in clinical epidemiology and diagnostics, the consortium will focus on Africa and South Asia.

As a first step, partners will perform an epidemiological assessment of relevant NIDs and the existing diagnostic capacity in the participating NID-endemic countries. Next, the plan is to perform clinical studies on the three NID-related syndromes as well as develop novel diagnostic tests.

Considerable work has been devoted towards a rapid diagnostic test for human African trypanosomiasis (HAT), which has already passed phase II evaluation. Phase III evaluation is scheduled in the near future.

Cost-effectiveness analyses are underway in different countries to find the most financially viable solution for regional NID management. The aim is to overcome vertical approaches in NID management and improve the quality of offered healthcare. For this purpose, local personnel are undergoing extensive training on diagnosis and disease management.

Collectively, the activities of the NIDIAG study will provide clinicians important tools towards NID management and treatment. Long-term the aim is to rationalise drug use, and avoid disease progression, thereby reducing NID-associated morbidity and mortality.

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