DESIGNING CATALYSIS

Designing catalysis: Nitrogen-carbon ylids as methylene donors

Coordinatore	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH    more  Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 contact info Titolo: Prof. Nome: Peter Cognome: Chen Email: send email Telefono: +41 44 632 47 88 Fax: +41 44 632 12 80
Nazionalità Coordinatore	Switzerland [CH]
Totale costo	178˙101 €
EC contributo	178˙101 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2010-IEF
Funding Scheme	MC-IEF
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-04-01   -   2013-03-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZURICH  Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 contact info Titolo: Prof. Nome: Peter Cognome: Chen Email: send email Telefono: +41 44 632 47 88 Fax: +41 44 632 12 80	CH (ZUERICH)	coordinator	178˙101.60

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 Obiettivo del progetto (Objective)

'Catalyst optimization is currently predominantly done by screening a large number of catalysts, rarely catalysts are designed by either chemical intuition or molecular modelling. In this proposal we will try to develop -by design- a new catalytic protocol using environmental benign reagents for the synthesis of cyclopropanes. The inspiration for this work stems from an interesting historical anomaly. In early work of Nobel prize laureate Georg Wittig cyclopropanation by the reaction of N-C-ylids as methylene donors with olefins was reported. Later these results were retracted. Possibly, traces of transition metals in one of the reagents were responsible for these inconsistent results. This observation prompts us to start an investigation of the interaction of N-C-ylids with transition metals. In this proposal we will combine (in)organic synthesis, mass spectrometry and molecular modelling to study the interaction of N-C-ylids with transition metals. Thorough understanding of these reactive intermediates will lead to novel synthetic (ideally catalytic) routes to cyclopropanes and the use of these intermediates in related synthetic transformations. Thus testing, validating and further developing our tools for design of catalysis and providing a environmentally benign industrial route to cyclopropanes.'