ATACC

Polycomb and Trithorax Group Proteins: Master Regulators of Adipose Tissue Function?

 Coordinatore MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. 

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Mr.
Nome: Patrice
Cognome: Wegener
Email: send email
Telefono: +49 7071 6011791
Fax: +49 7071 6011793

 Nazionalità Coordinatore Germany [DE]
 Totale costo 162˙242 €
 EC contributo 162˙242 €
 Programma FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
 Code Call FP7-PEOPLE-2010-IEF
 Funding Scheme MC-IEF
 Anno di inizio 2012
 Periodo (anno-mese-giorno) 2012-06-01   -   2014-05-31

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.

 Organization address address: Hofgartenstrasse 8
city: MUENCHEN
postcode: 80539

contact info
Titolo: Mr.
Nome: Patrice
Cognome: Wegener
Email: send email
Telefono: +49 7071 6011791
Fax: +49 7071 6011793

DE (MUENCHEN) coordinator 162˙242.40

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

cell    metabolic    diabetes    tissue    prevalence    gene    mice    obesity    first    pcg    disorders    chromatin    function    human    critical    metabolically    inducible    proteins    trx    adipose    silencing    disease    developmental   

 Obiettivo del progetto (Objective)

'Obesity and lipoatrophy are characterised by excess and paucity respectively of white adipose tissue. Both associated with insulin resistance, diabetes and cardiovascular disease, their prevalence will exceed 1 billion people by 2030. The convergence in metabolic phenotype of these two disparate disorders highlights how a precisely controlled, metabolically active adipose tissue is essential for proper health. Polycomb/Trithorax group (PcG/Trx) proteins were first identified in D. melanogaster as modulators of developmental patterning genes and are now recognized as fundamental executors of a chromatin-based silencing system that, capable of activating or silencing entire gene sets, is critical for multicellular development, differentiation and stem cell turnover. One of the most interesting features of PcG-induced gene-silencing patterns is to be transmitted through multiple cell divisions, thus touting them as mediators of cellular memory and critical to the stabilities of virtually all cell fates. Recent findings suggest a robust potential of PcG proteins to downregulate key developmental pathways involved in adipogenesis and adipose tissue function. Here we aim to define the role of PcG/Trx proteins in adipose tissue development, maintenance and function in vivo. This will be achieved by a multi-faceted approach including 1.functional characterization of temporally-inducible adipose tissue-specific PcG/Trx knock-out mice, 2.parallel profiling of gene expression, chromatin state, and PcG binding in mice and in highly characterized human samples from control and metabolically diseased patients, and 3.determination of mechanism through gain and loss-of-function approaches in vitro. Our plan merges the power of inducible gene targeting in mice with human genetics and disease biology. These approaches will help us understanding the role of chromatin remodeling in steady-state adipose tissue function and provide first hints at its contribution towards human disease.'

Introduzione (Teaser)

The prevalence of diabetes and obesity is continuously increasing. Delineating the state and function of adipose tissue in metabolic disorders is of primary importance for designing novel therapies.

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