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ULTRADIAN SIGNED

Dynamic hormone diagnostics

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ULTRADIAN project word cloud

Explore the words cloud of the ULTRADIAN project. It provides you a very rough idea of what is the project "ULTRADIAN" about.

lt    lcmsms    ultradian    24    unprecedented    conventional    producing    mass    points    multiplex    hurdles    hormonome    analyte    life    stakeholders    diseases    sampling    specificity    hormone    extension    fraction    endocrine    hour    cycling    purposes    single    poses    multiple    detect    subcutaneous    lcms    microdialysate    levels    monitoring    revolutionize    chromatography    vs    limited    clinical    collector    timeline    combined    tandem    treatment    pituitary    circadian    always    patient    accompanied    severely    diagnostics    ambulatory    tends    diagnostic    profiling    time    validate    care    sensitivity    ultrasensitive    consuming    overcome    adrenal    collection    disorders    markets    minute    random    health    person    six    fractions    ms    populations    economisation    lack    academic    cycle    daily    setting    losing    rapid    hours    impractical    72    commercial    generate    assays    hormonomes    absolute    simplified    portable    dynamic    healthy    liquid    proximity    abnormalities    demonstration    patterns    spectroscopy    secretion    routine    proseek    replacing   

Project "ULTRADIAN" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITETET I BERGEN 

Organization address
address: MUSEPLASSEN 1
city: BERGEN
postcode: 5020
website: www.uib.no

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Norway [NO]
 Project website http://www.ultradian.eu
 Total cost 5˙999˙381 €
 EC max contribution 5˙999˙381 € (100%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2014-two-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITETET I BERGEN NO (BERGEN) coordinator 2˙002˙047.00
2    UNIVERSITY OF BRISTOL UK (BRISTOL) participant 1˙221˙521.00
3    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 938˙307.00
4    PERIFEREIAKO GENIKO NOSOKOMEIO ATHINON EVAGGELISMOS EL (ATHINA) participant 713˙281.00
5    OLINK PROTEOMICS AB SE (UPPSALA) participant 686˙725.00
6    DESIGNWORKS WINDSOR LTD UK (Windsor) participant 437˙500.00
7    MOLECULINK AB SE (UPPSALA) participant 0.00

Map

 Project objective

We propose to revolutionize current endocrine diagnostics by replacing conventional, time-consuming single-analyte hormone assays with ambulatory dynamic endocrine diagnostics. Disorders of the adrenal and pituitary endocrine systems are not only accompanied by changes in absolute hormone levels, but also secretion patterns. The rapid circadian (24 hour) and ultradian (< 24 hour) cycling of hormone levels poses diagnostic challenges since random measurements do not always detect abnormalities. Furthermore, monitoring of treatment of endocrine diseases are often severely limited by lack of multiple measurements at different time points, which is impractical in an out-patient setting.

To overcome these hurdles academic and commercial partners propose to:

• Develop a novel microdialysate sampling and analysis system for adrenal and pituitary hormonome profiling

• Validate the method in healthy vs. six populations with endocrine disorders

• Promote the system for demonstration in routine clinical practice by dissemination of results to relevant European stakeholders The portable fraction collector for subcutaneous microdialysate combined with state-or-the-art ultrasensitive assays by liquid chromatography tandem mass spectroscopy (LCMS/MS) and multiplex proximity extension assays (Proseek), will allow collection of 10 minute fractions for up to 72 hours while the person tends to daily life activities. LCMSMS and Proseek assays can generate a timeline of “hormonomes” covering the 24 hour cycle without losing sensitivity and specificity, producing not only hormone levels, but also secretion patterns for diagnostics and monitoring purposes.

ULTRADIAN will deliver an ambulatory diagnostic system with unprecedented sensitivity and specificity for simplified diagnostics and monitoring of endocrine conditions, economisation of health care, and new products and markets for the European diagnostic sector.

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The information about "ULTRADIAN" are provided by the European Opendata Portal: CORDIS opendata.

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