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Ageing with elegans SIGNED

Validating C. elegans healthspan model for better understanding factors causing health and disease, to develop evidence based prevention, diagnostic, therapeutic and other strategies.

Total Cost €

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EC-Contrib. €

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Partnership

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Project "Ageing with elegans" data sheet

The following table provides information about the project.

Coordinator
KATHOLIEKE UNIVERSITEIT LEUVEN 

Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000
website: www.kuleuven.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Project website http://www.h2020awe.eu/
 Total cost 7˙305˙146 €
 EC max contribution 6˙573˙680 € (90%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-PHC-2014-two-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 1˙304˙400.00
2    HUMBOLDT-UNIVERSITAET ZU BERLIN DE (BERLIN) participant 566˙250.00
3    AnalytiCon Discovery GmbH DE (Potsdam) participant 533˙531.00
4    BIOPOLIS SL ES (PATERNA VALENCIA) participant 532˙075.00
5    ISTITUTO SUPERIORE DI SANITA IT (ROMA) participant 507˙250.00
6    AARHUS UNIVERSITET DK (AARHUS C) participant 500˙317.00
7    UNIVERSITEIT GENT BE (GENT) participant 468˙425.00
8    UNIVERSITATSMEDIZIN ROSTOCK DE (ROSTOCK) participant 387˙500.00
9    ABIOMICS EUROPE KFT HU (BUDAPEST) participant 347˙312.00
10    THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA CORP US (PHILADELPHIA) participant 318˙956.00
11    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) participant 308˙500.00
12    KAROLINSKA INSTITUTET SE (STOCKHOLM) participant 251˙726.00
13    AGILENT TECHNOLOGIES BELGIUM NV BE (DIEGEM) participant 188˙437.00
14    TARTU ULIKOOL EE (TARTU) participant 185˙750.00
15    TERVEYDEN JA HYVINVOINNIN LAITOS FI (HELSINKI) participant 173˙250.00
16    CARTAGENIA NV BE (LEUVEN) participant 0.00
17    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) participant 0.00
18    TSINGHUA UNIVERSITY CN (BEIJING) participant 0.00

Map

 Project objective

Healthspan (the life period when one is generally healthy and free from serious disease) depends on nature (genetic make-up) and nurture (environmental influences, from the earliest stages of development throughout life). Genetic studies increasingly reveal mutations and polymorphisms that may affect healthspan. Similarly, claims abound about lifestyle modifications or treatments improving healthspan. In both cases, rigorous testing is hampered by the long lifespan of model organisms like mice (let alone humans) and the difficulty of introducing genetic changes to examine the phenotype of the altered genome. We will develop C. elegans as a healthspan model. Already validated extensively as an ageing model, this organism can be readily modified genetically, and effects of environmental manipulations on healthspan can be measured in days or weeks. Once validated as a healthspan model, it can be used for an initial assessment of preventive and therapeutic measures for humans, as well as for risk identification and the initial evaluation of potential biomarkers. It will also prove useful to study interactions between genetic and various environmental factors.

 Deliverables

List of deliverables.
Project website Websites, patent fillings, videos etc. 2019-11-21 16:45:38
Press release Websites, patent fillings, videos etc. 2019-11-21 16:45:38

Take a look to the deliverables list in detail:  detailed list of Ageing with elegans deliverables.

 Publications

year authors and title journal last update
List of publications.
2016 Georg Fuellen, Paul Schofield, Thomas Flatt, Ralf-Joachim Schulz, Fritz Boege, Karin Kraft, Gerald Rimbach, Saleh Ibrahim, Alexander Tietz, Christian Schmidt, Rüdiger Köhling, Andreas Simm
Living Long and Well: Prospects for a Personalized Approach to the Medicine of Ageing
published pages: 409-416, ISSN: 0304-324X, DOI: 10.1159/000442746
Gerontology 62/4 2019-11-21
2016 Walter Luyten, Peter Antal, Bart P. Braeckman, Jake Bundy, Francesca Cirulli, Christopher Fang-Yen, Georg Fuellen, Armand Leroi, Qingfei Liu, Patricia Martorell, Andres Metspalu, Markus Perola, Michael Ristow, Nadine Saul, Liliane Schoofs, Karsten Siems, Liesbet Temmerman, Tina Smets, Alicja Wolk, Suresh I. S. Rattan
Ageing with elegans: a research proposal to map healthspan pathways
published pages: 771-782, ISSN: 1389-5729, DOI: 10.1007/s10522-016-9644-x
Biogerontology 17/4 2019-11-21
2016 Daniela Ohde, Mark Moeller, Julia Brenmoehl, Christina Walz, Siriluck Ponsuksili, Manfred Schwerin, Georg Fuellen, Andreas Hoeflich
Advanced Running Performance by Genetic Predisposition in Male Dummerstorf Marathon Mice (DUhTP) Reveals Higher Sterol Regulatory Element-Binding Protein (SREBP) Related mRNA Expression in the Liver and Higher Serum Levels of Progesterone
published pages: e0146748, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0146748
PLOS ONE 11/1 2019-11-21

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The information about "AGEING WITH ELEGANS" are provided by the European Opendata Portal: CORDIS opendata.

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