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Ageing with elegans SIGNED

Validating C. elegans healthspan model for better understanding factors causing health and disease, to develop evidence based prevention, diagnostic, therapeutic and other strategies.

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

Ageing with elegans project word cloud

Explore the words cloud of the Ageing with elegans project. It provides you a very rough idea of what is the project "Ageing with elegans" about.

reveal period depends life identification earliest extensively initial therapeutic environmental similarly nurture hampered genetically interactions elegans prove healthspan serious mutations weeks readily influences days organisms humans healthy validated rigorous organism model stages alone genome abound measured difficulty modifications preventive once nature mice phenotype free altered manipulations introducing evaluation genetic disease claims treatments polymorphisms risk ageing lifespan generally lifestyle modified examine biomarkers

Project "Ageing with elegans" data sheet

The following table provides information about the project.

Coordinator	KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Belgium [BE]
Project website	http://www.h2020awe.eu/
Total cost	7˙305˙146 €
EC max contribution	6˙573˙680 € (90%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-PHC-2014-two-stage
Funding Scheme	RIA
Starting year	2015
Duration (year-month-day)	from 2015-05-01 to 2020-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KATHOLIEKE UNIVERSITEIT LEUVEN KATHOLIEKE UNIVERSITEIT LEUVEN Organization address address: OUDE MARKT 13 city: LEUVEN postcode: 3000 website: www.kuleuven.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	coordinator	1˙304˙400.00
2	HUMBOLDT-UNIVERSITAET ZU BERLIN HUMBOLDT-UNIVERSITAET ZU BERLIN Organization address address: UNTER DEN LINDEN 6 city: BERLIN postcode: 10117 website: www.hu-berlin.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	participant	566˙250.00
3	AnalytiCon Discovery GmbH AnalytiCon Discovery GmbH Organization address address: Hermannswerder Haus 17 city: Potsdam postcode: 14473 website: www.ac-discovery.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (Potsdam)	participant	533˙531.00
4	BIOPOLIS SL BIOPOLIS SL Organization address address: CALLE CATEDRATICO AGUSTIN ESCARDINO 9 city: PATERNA VALENCIA postcode: 46980 website: www.biopolis.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (PATERNA VALENCIA)	participant	532˙075.00
5	ISTITUTO SUPERIORE DI SANITA ISTITUTO SUPERIORE DI SANITA Organization address address: Viale Regina Elena 299 city: ROMA postcode: 161 website: http://www.iss.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	507˙250.00
6	AARHUS UNIVERSITET AARHUS UNIVERSITET Organization address address: NORDRE RINGGADE 1 city: AARHUS C postcode: 8000 website: www.au.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (AARHUS C)	participant	500˙317.00
7	UNIVERSITEIT GENT UNIVERSITEIT GENT Organization address address: SINT PIETERSNIEUWSTRAAT 25 city: GENT postcode: 9000 website: http://www.ugent.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (GENT)	participant	468˙425.00
8	UNIVERSITATSMEDIZIN ROSTOCK UNIVERSITATSMEDIZIN ROSTOCK Organization address address: SCHILLINGALLEE 35 city: ROSTOCK postcode: 18055 website: www.med.uni-rostock.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ROSTOCK)	participant	387˙500.00
9	ABIOMICS EUROPE KFT ABIOMICS EUROPE KFT Organization address address: ZOLYOMI UT 23 city: BUDAPEST postcode: 1118 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	HU (BUDAPEST)	participant	347˙312.00
10	THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA CORP THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA CORP Organization address address: 3451 WALNUT STREET ROOM P 221 city: PHILADELPHIA postcode: 19104 website: www.upenn.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (PHILADELPHIA)	participant	318˙956.00
11	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	308˙500.00
12	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	251˙726.00
13	AGILENT TECHNOLOGIES BELGIUM NV AGILENT TECHNOLOGIES BELGIUM NV Organization address address: DE KLEETLAAN 5 city: DIEGEM postcode: 1831 website: http://www.ict-samurai.eu/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (DIEGEM)	participant	188˙437.00
14	TARTU ULIKOOL TARTU ULIKOOL Organization address address: ULIKOOLI 18 city: TARTU postcode: 51005 website: www.ut.ee contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EE (TARTU)	participant	185˙750.00
15	TERVEYDEN JA HYVINVOINNIN LAITOS TERVEYDEN JA HYVINVOINNIN LAITOS Organization address address: MANNERHEIMINTIE 166 city: HELSINKI postcode: 271 website: www.thl.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINKI)	participant	173˙250.00
16	CARTAGENIA NV CARTAGENIA NV Organization address address: TECHNOLOGIELAAN 3 city: LEUVEN postcode: 3001 website: www.cartagenia.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LEUVEN)	participant	0.00
17	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 website: https://www.ethz.ch/de.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZUERICH)	participant	0.00
18	TSINGHUA UNIVERSITY TSINGHUA UNIVERSITY Organization address address: QING HUA YUAN city: BEIJING postcode: 100084 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CN (BEIJING)	participant	0.00

Map

Project objective

Healthspan (the life period when one is generally healthy and free from serious disease) depends on nature (genetic make-up) and nurture (environmental influences, from the earliest stages of development throughout life). Genetic studies increasingly reveal mutations and polymorphisms that may affect healthspan. Similarly, claims abound about lifestyle modifications or treatments improving healthspan. In both cases, rigorous testing is hampered by the long lifespan of model organisms like mice (let alone humans) and the difficulty of introducing genetic changes to examine the phenotype of the altered genome. We will develop C. elegans as a healthspan model. Already validated extensively as an ageing model, this organism can be readily modified genetically, and effects of environmental manipulations on healthspan can be measured in days or weeks. Once validated as a healthspan model, it can be used for an initial assessment of preventive and therapeutic measures for humans, as well as for risk identification and the initial evaluation of potential biomarkers. It will also prove useful to study interactions between genetic and various environmental factors.

Deliverables

List of deliverables.
Project website	Websites, patent fillings, videos etc.	2019-11-21 16:45:38
Press release	Websites, patent fillings, videos etc.	2019-11-21 16:45:38

Take a look to the deliverables list in detail: detailed list of Ageing with elegans deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2016	Georg Fuellen, Paul Schofield, Thomas Flatt, Ralf-Joachim Schulz, Fritz Boege, Karin Kraft, Gerald Rimbach, Saleh Ibrahim, Alexander Tietz, Christian Schmidt, RÃ¼diger KÃ¶hling, Andreas Simm Living Long and Well: Prospects for a Personalized Approach to the Medicine of Ageing published pages: 409-416, ISSN: 0304-324X, DOI: 10.1159/000442746	Gerontology 62/4	2019-11-21
2016	Walter Luyten, Peter Antal, Bart P. Braeckman, Jake Bundy, Francesca Cirulli, Christopher Fang-Yen, Georg Fuellen, Armand Leroi, Qingfei Liu, Patricia Martorell, Andres Metspalu, Markus Perola, Michael Ristow, Nadine Saul, Liliane Schoofs, Karsten Siems, Liesbet Temmerman, Tina Smets, Alicja Wolk, Suresh I. S. Rattan Ageing with elegans: a research proposal to map healthspan pathways published pages: 771-782, ISSN: 1389-5729, DOI: 10.1007/s10522-016-9644-x	Biogerontology 17/4	2019-11-21
2016	Daniela Ohde, Mark Moeller, Julia Brenmoehl, Christina Walz, Siriluck Ponsuksili, Manfred Schwerin, Georg Fuellen, Andreas Hoeflich Advanced Running Performance by Genetic Predisposition in Male Dummerstorf Marathon Mice (DUhTP) Reveals Higher Sterol Regulatory Element-Binding Protein (SREBP) Related mRNA Expression in the Liver and Higher Serum Levels of Progesterone published pages: e0146748, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0146748	PLOS ONE 11/1	2019-11-21

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The information about "AGEING WITH ELEGANS" are provided by the European Opendata Portal: CORDIS opendata.