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SECURE SIGNED

Secondary prEvention of CardiovascUlaR disease in the Elderly trial

Total Cost €

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EC-Contrib. €

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Partnership

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Project "SECURE" data sheet

The following table provides information about the project.

Coordinator
FUNDACION CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III 

Organization address
address: C/ MELCHOR FERNANDEZ ALMAGRO 3
city: MADRID
postcode: 28029
website: www.cnic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://www.secure-h2020.eu/page/en/about-secure/objectives.php
 Total cost 7˙018˙801 €
 EC max contribution 5˙998˙786 € (85%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-PHC-2014-two-stage
 Funding Scheme /RIA
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACION CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III ES (MADRID) coordinator 1˙465˙972.00
2    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) participant 1˙152˙442.00
3    ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI IT (MILANO) participant 896˙086.00
4    SERVICIO MADRILENO DE SALUD ES (MADRID) participant 556˙028.00
5    UNIWERSYTET MEDYCZNY IM PIASTOW SLASKICH WE WROCLAWIU PL (WROCLAW) participant 382˙375.00
6    CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE BESANCON FR (BESANCON CEDEX) participant 374˙309.00
7    ARTTIC FR (PARIS) participant 330˙625.00
8    FERRER INTERNATIONAL ES (BARCELONA) participant 263˙574.00
9    VSEOBECNA FAKULTNI NEMOCNICE V PRAZE CZ (PRAHA 2) participant 242˙125.00
10    SEMMELWEIS EGYETEM HU (BUDAPEST) participant 238˙500.00
11    LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE UK (LONDON) participant 96˙750.00

Mappa

 Project objective

While Cardiovascular diseases (CVD) are the main cause of death worldwide, they are responsible for half of all deaths in Europe. The overall ageing of the European population and improving survival of patients with coronary heart disease has created a large population of older adults eligible for secondary prevention. Despite the established efficacy of cardiovascular medications, suboptimal adherence reduces their effectiveness and is the primary reason for suboptimal clinical benefit, contributing significantly to worsening of diseases and deaths at the population level. SECURE will be the first trial testing the efficacy of a fixed dose combination (FDC) polypill for secondary cardiovascular prevention in the elderly population (≥ 65 years old). The main objective is to evaluate the potential benefit of the FDC as a component of a cost-effective, globally available and comprehensive treatment strategy for secondary prevention of cardiovascular events (death from cardiovascular causes, nonfatal myocardial infarction, stroke, and hospitalisation requiring revascularisation) as compared to standard therapy (the three components of the polypill given separately). As part of the secondary endpoints, SECURE will compare the effect of both strategies on adherence and intermediate measures of risk factor control such as lipids and blood pressure. Importantly, it will also measure the pharmacoeconomic impact of the FDC intervention as well as regional differences in all outcomes. The five-year project will thus involve subjects from seven different countries: Spain, Italy, France, Germany, Hungary, Poland and the Czech Republic. The findings and conclusions obtained in SECURE will allow the drafting of clinical guidelines and recommendations that will provide useful guidance and will serve as a reference framework for all stakeholders involved in tackling major challenges related to secondary prevention and treatment of chronic diseases in the elderly population.

 Work performed, outcomes and results:  advancements report(s) 

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The information about "SECURE" are provided by the European Opendata Portal: CORDIS opendata.

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