Explore the words cloud of the TOPCAPI project. It provides you a very rough idea of what is the project "TOPCAPI" about.
The following table provides information about the project.
THE UNIVERSITY OF MANCHESTER
|Coordinator Country||United Kingdom [UK]|
|Total cost||5˙063˙361 €|
|EC max contribution||5˙063˙361 € (100%)|
1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
|Duration (year-month-day)||from 2017-01-01 to 2020-12-31|
Take a look of project's partnership.
|1||THE UNIVERSITY OF MANCHESTER||UK (MANCHESTER)||coordinator||1˙554˙128.00|
|2||ACIES BIO BIOTEHNOLOSKE RAZISKAVE IN RAZVOJ DOO||SI (LJUBLJANA)||participant||559˙250.00|
|3||NAICONS SRL||IT (SARONNO VA)||participant||535˙000.00|
|4||UNIVERSITY OF YORK||UK (YORK NORTH YORKSHIRE)||participant||531˙967.00|
|5||ASOCIACION DE INVESTIGACION INBIOTEC, INSTITUTO DE BIOTECHNOLOGIA DE LEON||ES (LEON)||participant||509˙842.00|
|6||FUNDACION CENTRO DE EXCELENCIA EN INVESTIGACION DE MEDICAMENTOS INNOVADORES EN ANDALUCIA||ES (ARMILLA GRANADA)||participant||499˙375.00|
|7||UNIVERZA V LJUBLJANI||SI (LJUBLJANA)||participant||449˙425.00|
|8||EXPLORA SRL||IT (ROMA)||participant||424˙372.00|
TOPCAPI will exploit the natural fabrication power of actinomycetes as microbial cell factories to produce three high value compounds: GE2270, a starter compound for the semi-synthesis of NAI-Acne, a new topical anti-acne drug in Phase II clinical trials; 6-desmethyl-tetracycline (6DM-TC) and 6-desmethyl 6-deshydro tetracycline (6DM6DH-TC), intermediates for semi-synthetic conversion to medically important type II polyketide tetracyclines (TC), e.g. minocycline, tigecycline, and the novel omadacycline, which is in Phase III clinical trials, to be used against Methicillin-resistant Staphylococcus aureus infections. Our work will focus on two bacterial host species: Streptomyces coelicolor and Streptomyces rimosus. These host species will be characterised using systems biology approaches, applying integrated data analysis to transcriptomics and metabolomics experiments, combined with predictive mathematical modelling to drive the rapid improvement of these microbial cell factories for industrial drug production using advanced metabolic and biosynthetic engineering approaches. At the same time, we will establish an expanded toolbox for the engineering of actinomycete bacteria as cell factories for other high added-value compounds.
In the proposed 4-year project, we will:
1. Host engineer two new actinomycete strains for industry-level improved heterologous compound production through integrating systems biology-driven strain design and state-of-the-art genome editing.
2. Engineer the biosynthesis pathways to obtain high-efficiency synthesis of GE2270 and new pathway variants for 6DM-TC and 6DM6DH-TC as well as improve its production purity.
3. Optimise the expression of the engineered target pathways in pre-engineered strains to achieve industrially viable production levels of ≈1 g/L for GE2270 and ≈24 g/L for 6DM-TC, while creating a complete novel production strain for 6DM6DH-TC.
|Project manager appointed||Other||2020-01-31 09:56:14|
|TOPCAPI Website||Websites, patent fillings, videos etc.||2020-01-31 09:56:14|
Take a look to the deliverables list in detail: detailed list of TOPCAPI deliverables.
|year||authors and title||journal||last update|
Francesco Del Carratore, Kamila Schmidt, Maria Vinaixa, Katherine A. Hollywood, Caitlin Greenland-Bews, Eriko Takano, Simon Rogers, Rainer Breitling
Integrated Probabilistic Annotation: A Bayesian-Based Annotation Method for Metabolomic Profiles Integrating Biochemical Connections, Isotope Patterns, and Adduct Relationships
published pages: 12799-12807, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.9b02354
|Analytical Chemistry 91/20||2020-02-04|
Emmanuele Severi, Gavin H. Thomas
Antibiotic export: transporters involved in the final step of natural product production
published pages: 805-818, ISSN: 1350-0872, DOI: 10.1099/mic.0.000794
Francesco Del Carratore, Konrad Zych, Matthew Cummings, Eriko Takano, Marnix H. Medema, Rainer Breitling
Computational identification of co-evolving multi-gene modules in microbial biosynthetic gene clusters
published pages: , ISSN: 2399-3642, DOI: 10.1038/s42003-019-0333-6
|Communications Biology 2/1||2020-02-04|
Adam Amara, Eriko Takano, Rainer Breitling
Development and validation of an updated computational model of Streptomyces coelicolor primary and secondary metabolism
published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-018-4905-5
|BMC Genomics 19/1||2020-01-31|
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The information about "TOPCAPI" are provided by the European Opendata Portal: CORDIS opendata.
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