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ENSAT-HT SIGNED

Application of omics-based strategies for improved diagnosis and treatment of endocrine hypertension

Total Cost €

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EC-Contrib. €

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Partnership

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 ENSAT-HT project word cloud

Explore the words cloud of the ENSAT-HT project. It provides you a very rough idea of what is the project "ENSAT-HT" about.

attributable    promotion    causes    quality    metabolic    therapeutic    forms    primary    preclinical    hypertension    health    disease    group    complications    small    million    validated    paraganglioma    data    omics    cushing    exists    personalised    syndrome    adrenal    endocrine    screening    metabolomics    population    underlying    treatment    efficient    hypertensives    profiles    diminished    therapy    genomics    benefit    pa    ischemic    diseases    stratification    cluster    annotations    prevention    arterial    stratifying    cs    integrating    deaths    functional    arsenal    identification    responsible    stratified    cardiovascular    curative    ing    ppgl    patients    life    heart    increments    phenome    sub    thirds    genetics    profiling    detection    hypertensive    throughput    groups    blood    45    pressure    biomarkers    bioinformatics    62    hormones    worldwide    regulation    phenotypes    49    risk    disorders    cerebrovascular    optimal    secondary    aldosteronism    pheochromocytoma   

Project "ENSAT-HT" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://www.ensat-ht.eu/index.php
 Total cost 8˙440˙635 €
 EC max contribution 7˙607˙337 € (90%)
 Programme 1. H2020-EU.3.1.2. (Preventing disease)
 Code Call H2020-PHC-2014-two-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙445˙501.00
2    UNIVERSITY OF DUNDEE UK (DUNDEE) participant 1˙011˙755.00
3    ASSISTANCE PUBLIQUE HOPITAUX DE PARIS FR (PARIS) participant 988˙500.00
4    UNIVERSITY OF GLASGOW UK (GLASGOW) participant 766˙380.00
5    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) participant 734˙500.00
6    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) participant 660˙653.00
7    TECHNISCHE UNIVERSITAET DRESDEN DE (DRESDEN) participant 446˙459.00
8    INSERM TRANSFERT SA FR (PARIS) participant 424˙375.00
9    HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH DE (NEUHERBERG) participant 404˙200.00
10    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) participant 309˙326.00
11    UNIVERSITA DEGLI STUDI DI TORINO IT (TORINO) participant 285˙969.00
12    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 129˙719.00
13    UNIVERSITY OF MELBOURNE AU (MELBOURNE) participant 0.00

Map

 Project objective

Arterial hypertension affects up to 45% of the general population and is responsible for 7.1 million deaths per year worldwide. Although a large therapeutic arsenal exists, blood pressure control is sub-optimal in up to two thirds of patients. Yet, even small increments in blood pressure are associated with increased cardiovascular risk, with 62% of cerebrovascular disease and 49% of ischemic heart disease being attributable to hypertension. Detection of secondary forms of hypertension is key to targeted management of the underlying disease and prevention of cardiovascular complications. Endocrine forms of hypertension represent major targets for stratified approaches of health promotion. They include a group of adrenal disorders resulting in increased production of hormones affecting blood pressure regulation: primary aldosteronism (PA), pheochromocytoma/functional paraganglioma (PPGL) and Cushing’s syndrome (CS). These diseases are associated with increased cardiovascular and metabolic risk and with diminished quality of life. This project will develop and evaluate an omics-based stratified health promotion program for patients with endocrine forms of hypertension. We will define specific omics profiles for patients with PA, PPGL and CS by integrating high throughput genetics, genomics and metabolomics data with phenome annotations through bioinformatics modelling. Established profiles will be validated as stratification biomarkers and applied to the screening of referred hypertensive patients for both stratifying primary forms of hypertension for effective and cost efficient therapy as well as improving identification of endocrine causes for curative treatment and prevention of cardiovascular and metabolic complications. Omics-based profiling should allow identification of patients with preclinical phenotypes along with those hypertensives that cluster into specific endocrine groups who may benefit from personalised treatment.

 Deliverables

List of deliverables.
Establishment of project web site Websites, patent fillings, videos etc. 2020-04-22 09:53:28

Take a look to the deliverables list in detail:  detailed list of ENSAT-HT deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 Wiebke Arlt, Katharina Lang, Alice J. Sitch, Anna S. Dietz, Yara Rhayem, Irina Bancos, Annette Feuchtinger, Vasileios Chortis, Lorna C. Gilligan, Philippe Ludwig, Anna Riester, Evelyn Asbach, Beverly A. Hughes, Donna M. O’Neil, Martin Bidlingmaier, Jeremy W. Tomlinson, Zaki K. Hassan-Smith, D. Aled Rees, Christian Adolf, Stefanie Hahner, Marcus Quinkler, Tanja Dekkers, Jaap Deinum, Michael Biehl
Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism
published pages: , ISSN: 2379-3708, DOI: 10.1172/jci.insight.93136
JCI Insight 2/8 2020-04-22
2017 Graeme Eisenhofer, Mirko Peitzsch, Denise Kaden, Katharina Langton, Christina Pamporaki, Jimmy Masjkur, George Tsatsaronis, Anastasios Mangelis, Tracy A. Williams, Martin Reincke, Jacques W.M. Lenders, Stefan R. Bornstein
Reference intervals for plasma concentrations of adrenal steroids measured by LC-MS/MS: Impact of gender, age, oral contraceptives, body mass index and blood pressure status
published pages: 115-124, ISSN: 0009-8981, DOI: 10.1016/j.cca.2017.05.002
Clinica Chimica Acta 470 2020-04-22
2016 Graeme Eisenhofer, Mirko Peitzsch, Brett C. McWhinney
Impact of LC-MS/MS on the laboratory diagnosis of catecholamine-producing tumors
published pages: 106-116, ISSN: 0165-9936, DOI: 10.1016/j.trac.2016.01.027
TrAC Trends in Analytical Chemistry 84 2020-04-22
2017 Stacy Robertson, Louise A. Diver, Samantha Alvarez-Madrazo, Craig Livie, Ayesha Ejaz, Robert Fraser, John M. Connell, Scott M. MacKenzie, Eleanor Davies
Regulation of Corticosteroidogenic Genes by MicroRNAs
published pages: 1-11, ISSN: 1687-8337, DOI: 10.1155/2017/2021903
International Journal of Endocrinology 2017 2020-04-22
2017 Rao, Dipti; Peitzsch, Mirko; Prejbisz, Aleksander; Hanus, Katarzyna; Fassnacht, Martin; Beuschlein, Felix; Brugger, Christina; Fliedner, Stephanie; Langton, Katharina; Pamporaki, Christina; Gudziol, Volker; Stell, Anthony; Januszewicz, Andrzej; Timmers, Henri J L M; Lenders, Jacques W M; Eisenhofer, Graeme
Plasma methoxytyramine: clinical utility with metanephrines for diagnosis of pheochromocytoma and paraganglioma
published pages: 103-113, ISSN: 0804-4643, DOI: 10.5167/uzh-138824
European Journal of Endocrinology 2 2020-04-22
2018 Graeme Eisenhofer, Jimmy Masjkur, Mirko Peitzsch, Guido Di Dalmazi, Martin Bidlingmaier, Matthias Grüber, Julia Fazel, Andrea Osswald, Felix Beuschlein, Martin Reincke
Plasma Steroid Metabolome Profiling for Diagnosis and Subtyping Patients with Cushing Syndrome
published pages: 586-596, ISSN: 0009-9147, DOI: 10.1373/clinchem.2017.282582
Clinical Chemistry 64/3 2020-04-22
2015 Tracy Ann Williams, Mirko Peitzsch, Anna S. Dietz, Tanja Dekkers, Martin Bidlingmaier, Anna Riester, Marcus Treitl, Yara Rhayem, Felix Beuschlein, Jacques W.M. Lenders, Jaap Deinum, Graeme Eisenhofer, Martin Reincke
Genotype-Specific Steroid Profiles Associated With Aldosterone-Producing AdenomasNovelty and Significance
published pages: 139-145, ISSN: 0194-911X, DOI: 10.1161/HYPERTENSIONAHA.115.06186
Hypertension 67/1 2020-04-22
2018 Thomas Nind, James Galloway, Gordon McAllister, Donald Scobbie, Wilfred Bonney, Christopher Hall, Leandro Tramma, Parminder Reel, Martin Groves, Philip Appleby, Alex Doney, Bruce Guthrie, Emily Jefferson
The Research Data Management Platform (RDMP): A novel, process driven, open-source tool for the management of longitudinal cohorts of clinical data
published pages: P 115-124, ISSN: 2047-217X, DOI: 10.1093/gigascience/giy060
GigaScience 2020-04-22
2015 M. Moors, T. Williams, J. Deinum, G. Eisenhofer, M. Reincke, J. Lenders
Steroid Hormone Production in Patients with Aldosterone Producing Adenomas
published pages: 967-972, ISSN: 0018-5043, DOI: 10.1055/s-0035-1565225
Hormone and Metabolic Research 47/13 2020-04-22
2018 Fabio L. Fernandes-Rosa, Georgios Daniil, Ian J. Orozco, Corinna Göppner, Rami El Zein, Vandana Jain, Sheerazed Boulkroun, Xavier Jeunemaitre, Laurence Amar, Hervé Lefebvre, Thomas Schwarzmayr, Tim M. Strom, Thomas J. Jentsch, Maria-Christina Zennaro
A gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism
published pages: 355-361, ISSN: 1061-4036, DOI: 10.1038/s41588-018-0053-8
Nature Genetics 50/3 2020-04-22
2016 Nelly Burnichon, Alexandre Buffet, Anne-Paule Gimenez-Roqueplo
Pheochromocytoma and paraganglioma
published pages: 5-10, ISSN: 1040-8746, DOI: 10.1097/CCO.0000000000000249
Current Opinion in Oncology 28/1 2020-04-22
2016 G. Eisenhofer, T. Dekkers, M. Peitzsch, A. S. Dietz, M. Bidlingmaier, M. Treitl, T. A. Williams, S. R. Bornstein, M. Haase, L. C. Rump, H. S. Willenberg, F. Beuschlein, J. Deinum, J. W. M. Lenders, M. Reincke
Mass Spectrometry-Based Adrenal and Peripheral Venous Steroid Profiling for Subtyping Primary Aldosteronism
published pages: 514-524, ISSN: 0009-9147, DOI: 10.1373/clinchem.2015.251199
Clinical Chemistry 62/3 2020-04-22
2016 Rodrigo A. Toledo, Nelly Burnichon, Alberto Cascon, Diana E. Benn, Jean-Pierre Bayley, Jenny Welander, Carli M. Tops, Helen Firth, Trish Dwight, Tonino Ercolino, Massimo Mannelli, Giuseppe Opocher, Roderick Clifton-Bligh, Oliver Gimm, Eamonn R. Maher, Mercedes Robledo, Anne-Paule Gimenez-Roqueplo, Patricia L. M. Dahia
Consensus Statement on next-generation-sequencing-based diagnostic testing of hereditary phaeochromocytomas and paragangliomas
published pages: , ISSN: 1759-5029, DOI: 10.1038/nrendo.2016.185
Nature Reviews Endocrinology 2020-04-22
2018 Fabio L. Fernandes-Rosa, Georgios Daniil, Ian J. Orozco, Corinna Göppner, Rami El Zein, Vandana Jain, Sheerazed Boulkroun, Xavier Jeunemaitre, Laurence Amar, Hervé Lefebvre, Thomas Schwarzmayr, Tim M. Strom, Thomas J. Jentsch, Maria-Christina Zennaro
A gain-of-function mutation in the CLCN2 chloride channel gene causes primary aldosteronism
published pages: 355-361, ISSN: 1061-4036, DOI: 10.1038/s41588-018-0053-8
Nature Genetics 50/3 2020-04-22

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