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EPoS SIGNED

Elucidating Pathways of Steatohepatitis

Total Cost €

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EC-Contrib. €

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Partnership

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 EPoS project word cloud

Explore the words cloud of the EPoS project. It provides you a very rough idea of what is the project "EPoS" about.

immune    unknown    translation    steatohepatitis    rate    determines    healthcare    worldwide    drive    accumulation    healing    omics    liver    fibrosis    pathophysiological    fat    lipid    entire    activation    population    patients    nash    fatty    absence    disease    invasive    variability    alcoholic    hepatocellular    medical    record    30    promises    strongly    carcinoma    cancer    risk    definitive    substantial    biology    2020    cirrhosis    morbidity    variation    cohort    understand    mellitus    stratification    acceptable    hepatic    progressive    biopsy    pathologies    carbohydrate    dimensional    once    patient    care    epidemics    homeostasis    consumption    atlas    environmental    risky    cardiovascular    sits    nafld    alcohol    inflammation    therapy    underlying    inflammatory    intersection    hinder    single    severity    spectrum    treatment    diagnosis    drivers    steatosis    benefit    transplants    progression    inter    aging    costly    biological    perturbed    aetiology    wound    closely    obesity    procedure    diabetes    t2dm    plus    epos    multiple    pathogenic   

Project "EPoS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF NEWCASTLE UPON TYNE 

Organization address
address: KINGS GATE
city: NEWCASTLE UPON TYNE
postcode: NE1 7RU
website: http://www.ncl.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://www.epos-nafld.eu
 Total cost 6˙173˙021 €
 EC max contribution 5˙985˙521 € (97%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-PHC-2014-two-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2019-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF NEWCASTLE UPON TYNE UK (NEWCASTLE UPON TYNE) coordinator 1˙629˙948.00
2    INST CARDIOMETABOLISME NUTRITION ICAN FR (PARIS) participant 1˙012˙317.00
3    UNIVERSITA DEGLI STUDI DI TORINO IT (TORINO) participant 662˙635.00
4    OREBRO UNIVERSITY SE (OREBRO) participant 568˙059.00
5    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 533˙065.00
6    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 517˙990.00
7    IXSCIENT LIMITED UK (TWICKENHAM MIDDLESEX) participant 298˙750.00
8    UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ DE (Mainz) participant 261˙000.00
9    NORDIC BIOSCIENCE A/S DK (HERLEV) participant 187˙500.00
10    NOVO NORDISK INVEST 4 A/S DK (BAGSVAERD) participant 184˙256.00
11    HELSINGIN YLIOPISTO FI (HELSINGIN YLIOPISTO) participant 130˙000.00
12    NORDIC BIOSCIENCE COMPOUND DEVELOPMENT A/S DK (Helev) participant 0.00

Map

 Project objective

Strongly associated with the epidemics of obesity and type 2 diabetes mellitus (T2DM) that are testing healthcare systems worldwide, Non-Alcoholic Fatty Liver Disease (NAFLD) is an increasingly common cause of advanced liver disease in the aging population of Europe. NAFLD is a spectrum of hepatic fat accumulation (steatosis); steatosis plus inflammation (non-alcoholic steatohepatitis, NASH); fibrosis/cirrhosis; and hepatocellular carcinoma in the absence of high alcohol consumption. Up to 30% of the EU population have NAFLD, which will be the main aetiology underlying liver transplants by 2020. However, NAFLD is characterized by substantial inter-patient variability in severity and rate of progression. What determines this is unknown. A large population is at risk, but only some experience morbidity. NAFLD severity is currently best assessed by liver biopsy, an invasive, costly and risky procedure - factors that hinder treatment. There is a need to understand the biological and environmental factors that drive inter-patient variability and to develop robust and more acceptable methods for diagnosis, risk stratification and therapy so that effective medical care may be targeted to those that will benefit most. The overall EPoS concept is that improved understanding of pathogenic processes and drivers of disease progression will best be achieved when multiple ‘omics’ approaches are applied to a single cohort of patients to build a multi-dimensional record of how systems are perturbed across the entire spectrum of disease. NAFLD sits at the intersection of key biological processes: carbohydrate/lipid homeostasis, immune/inflammatory activation, wound healing/fibrosis and cancer biology. Once completed, EPoS promises to deliver a substantial and definitive atlas of pathophysiological variation across a spectrum of progressive liver disease. Translation of these findings will therefore impact on closely related pathologies including T2DM and cardiovascular disease.

 Deliverables

List of deliverables.
Final reports summarising recruitment into the EPoS database, biobanked samples availability, and longitudinal outcome studies Documents, reports 2020-02-12 18:04:46
Risk assessment procedure Documents, reports 2019-12-17 15:24:27
Report on data management plan for the EPoS project Documents, reports 2019-12-17 15:24:27
Project Handbook Documents, reports 2019-12-17 15:24:27
Detailed dissemination plan Documents, reports 2019-12-17 15:24:27

Take a look to the deliverables list in detail:  detailed list of EPoS deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 Rosso, Chiara; Younes, Ramy; Fabrizia, Carli; Melania, Gaggini; Lavinia, Mezzabotta; Marietti, Milena; Federico, Salomone; Gambino, Roberto; Saba, Francesca; Emma, Buzzigoli; Demetrio, Ciociaro; Caviglia, GIAN PAOLO; Morello, Elisabetta; Abate, Maria Lorena; Smedile, Antonina; Ciancio, Alessia; Cassader, Maurizio; Saracco, Giorgio Maria; Amalia, Gastaldelli; Bugianesi, Elisabetta
Plasma Selenoprotein P levels are related to adipose tissue insulin resistance, composition of free fatty acids and liver fibrosis in non-diabetic patients with Non Alcoholic Fatty Liver Disease
published pages: , ISSN: , DOI:
9 2020-01-30
2019 Marie Boyle, Dina Tiniakos, Jorn M. Schattenberg, Vlad Ratziu, Elisabetta Bugianessi, Salvatore Petta, Claudia P. Oliveira, Olivier Govaere, Ramy Younes, Stuart McPherson, Pierre Bedossa, Mette J Nielsen, Morten Karsdal, Diana Leeming, Stuart Kendrick, Quentin M. Anstee
Performance of the PRO-C3 collagen neo-epitope biomarker in non-alcoholic fatty liver disease
published pages: 188-198, ISSN: 2589-5559, DOI: 10.1016/j.jhepr.2019.06.004
JHEP Reports 1/3 2020-01-29
2018 Gemma F. Codner, Joffrey Mianné, Adam Caulder, Jorik Loeffler, Rachel Fell, Ruairidh King, Alasdair J. Allan, Matthew Mackenzie, Fran J. Pike, Christopher V. McCabe, Skevoulla Christou, Sam Joynson, Marie Hutchison, Michelle E. Stewart, Saumya Kumar, Michelle M. Simon, Loranne Agius, Quentin M. Anstee, Kirill E. Volynski, Dimitri M. Kullmann, Sara Wells, Lydia Teboul
Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants
published pages: , ISSN: 1741-7007, DOI: 10.1186/s12915-018-0530-7
BMC Biology 16/1 2020-01-29
2019 Morten A. Karsdal, Sara T. Hjuler, Yi Luo, Daniel G. K. Rasmussen, Mette J. Nielsen, Signe Holm Nielsen, Diana J. Leeming, Zachary Goodman, Robert H. Arch, Keyur Patel, Detlef Schuppan
Assessment of liver fibrosis progression and regression by a serological collagen turnover profile
published pages: G25-G31, ISSN: 0193-1857, DOI: 10.1152/ajpgi.00158.2018
American Journal of Physiology-Gastrointestinal and Liver Physiology 316/1 2020-01-29
2019 Fang Wei, Santosh Lamichhane, Matej Orešič, Tuulia Hyötyläinen
Lipidomes in health and disease: Analytical strategies and considerations
published pages: 115664, ISSN: 0165-9936, DOI: 10.1016/j.trac.2019.115664
TrAC Trends in Analytical Chemistry 120 2020-01-29
2019 Yvonne Huber, Daniel Pfirrmann, Ines Gebhardt, Christian Labenz, Nadine Gehrke, Beate K. Straub, Christian Ruckes, Heike Bantel, Eugenio Belda, Karine Clément, Diana J. Leeming, Morten A. Karsdal, Peter R. Galle, Perikles Simon, Jörn M. Schattenberg
Improvement of non-invasive markers of NAFLD from an individualised, web-based exercise program
published pages: 930-939, ISSN: 0269-2813, DOI: 10.1111/apt.15427
Alimentary Pharmacology & Therapeutics 50/8 2020-01-29
2015 Hannele Yki-Järvinen, Panu K. Luukkonen
Heterogeneity of non-alcoholic fatty liver disease
published pages: 2498-2500, ISSN: 1478-3223, DOI: 10.1111/liv.12970
Liver International 35/12 2020-01-29
2019 Feng Liu, George Boon‐Bee Goh, Dina Tiniakos, Aileen Wee, Wei‐Qiang Leow, Jing‐Min Zhao, Hui‐Ying Rao, Xiao‐Xiao Wang, Qin Wang, Wei‐Keat Wan, Kiat‐Hon Lim, Manuel Romero‐Gomez, Salvatore Petta, Elisabetta Bugianesi, Chee‐Kiat Tan, Stephen A. Harrison, Quentin M. Anstee, Pik‐Eu Jason Chang, Lai Wei
qFIBS: A Novel Automated Technique for Quantitative Evaluation of Fibrosis, Inflammation, Ballooning, and Steatosis in Patients With Nonalcoholic Steatohepatitis
published pages: , ISSN: 0270-9139, DOI: 10.1002/hep.30986
Hepatology 2020-01-29
2018 Emma Scott, Quentin M Anstee
Genetics of alcoholic liver disease and non-alcoholic steatohepatitis
published pages: s54-s59, ISSN: 1470-2118, DOI: 10.7861/clinmedicine.18-2-s54
Clinical Medicine 18/Suppl 2 2020-01-29
2018 Carli, F.; Gaggini, M.; Rosso, C.; Saponaro, C.; Barbieri, C.; Latta, V. D.; Buzzigoli, E.; Ciociaro, D.; Abate, M. L.; Marietti, M.; Younes, R.; Bugianesi, E.; Gastaldelli, A.
In non obese NAFLD increased plasma saturated fatty acids and insulin resistance are metabolic signatures of severity of liver disease
published pages: , ISSN: , DOI:
8 2020-01-29
2017 Vlad Ratziu
Non-pharmacological interventions in non-alcoholic fatty liver disease patients
published pages: 90-96, ISSN: 1478-3223, DOI: 10.1111/liv.13311
Liver International 37 2020-01-29
2019 Ramy Younes, Elisabetta Bugianesi
A spotlight on pathogenesis, interactions and novel therapeutic options in NAFLD
published pages: 80-82, ISSN: 1759-5045, DOI: 10.1038/s41575-018-0094-6
Nature Reviews Gastroenterology & Hepatology 16/2 2020-01-29
2019 Carolin Lackner, Dina Tiniakos
Fibrosis and alcohol-related liver disease
published pages: 294-304, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2018.12.003
Journal of Hepatology 70/2 2020-01-29
2019 Nadine Gehrke, Jana Biedenbach, Yvonne Huber, Beate K. Straub, Peter R. Galle, Perikles Simon, Jörn M. Schattenberg
Voluntary exercise in mice fed an obesogenic diet alters the hepatic immune phenotype and improves metabolic parameters – an animal model of life style intervention in NAFLD
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-38321-9
Scientific Reports 9/1 2020-01-29
2017 Younes, Ramy; Rosso, Chiara; Melania, Gaggini; Lavinia, Mezzabotta; Marietti, Milena; Fabrizia, Carli; Federico, Salomone; Emma, Buzzigoli; Caviglia, GIAN PAOLO; Chiara, Barbieri; Abate, Maria Lorena; Smedile, Antonina; Saracco, Giorgio Maria; Anstee, Quentin M.; Leeming, Diana J.; Amalia, Gastaldelli; Detlef, Schuppan; Bugianesi, Elisabetta
Insulin secretion and decreased glucose clearance are associated with enhanced fibrogenesis and a high risk of disease progression in non-diabetic patients with Non Alcoholic Fatty Liver Disease
published pages: , ISSN: , DOI:
9 2020-01-29
2019 Brandon D. Kayser, Marie Lhomme, Edi Prifti, Carla Da Cunha, Florian Marquet, Florian Chain, Isabelle Naas, Véronique Pelloux, Maria-Carlota Dao, Anatol Kontush, Salwa W. Rizkalla, Judith Aron-Wisnewsky, Luis G. Bermúdez-Humarán, Fiona Oakley, Philippe Langella, Karine Clément, Isabelle Dugail
Phosphatidylglycerols are induced by gut dysbiosis and inflammation, and favorably modulate adipose tissue remodeling in obesity
published pages: 4741-4754, ISSN: 0892-6638, DOI: 10.1096/fj.201801897r
The FASEB Journal 33/4 2020-01-29
2016 You Zhou, Matej Orešič, Marja Leivonen, Peddinti Gopalacharyulu, Jenni Hyysalo, Johanna Arola, An Verrijken, Sven Francque, Luc Van Gaal, Tuulia Hyötyläinen, Hannele Yki-Järvinen
Noninvasive Detection of Nonalcoholic Steatohepatitis Using Clinical Markers and Circulating Levels of Lipids and Metabolites
published pages: 1463-1472.e6, ISSN: 1542-3565, DOI: 10.1016/j.cgh.2016.05.046
Clinical Gastroenterology and Hepatology 14/10 2020-01-29
2017 Salvatore Petta, Mohammed Eslam, Luca Valenti, Elisabetta Bugianesi, Marco Barbara, Calogero Cammà, Marianna Porzio, Chiara Rosso, Silvia Fargion, Jacob George, Antonio Craxì
Metabolic syndrome and severity of fibrosis in nonalcoholic fatty liver disease: An age-dependent risk profiling study
published pages: 1389-1396, ISSN: 1478-3223, DOI: 10.1111/liv.13397
Liver International 37/9 2020-01-29
2018 Panu K. Luukkonen, Sanja Sädevirta, You Zhou, Brandon Kayser, Ashfaq Ali, Linda Ahonen, Susanna Lallukka, Véronique Pelloux, Melania Gaggini, Ching Jian, Antti Hakkarainen, Nina Lundbom, Helena Gylling, Anne Salonen, Matej Orešič, Tuulia Hyötyläinen, Marju Orho-Melander, Aila Rissanen, Amalia Gastaldelli, Karine Clément, Leanne Hodson, Hannele Yki-Järvinen
Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars
published pages: 1732-1739, ISSN: 0149-5992, DOI: 10.2337/dc18-0071
Diabetes Care 41/8 2020-01-29
2017 Younes, R; Rosso, C; Marietti, M; Caviglia, Gp; Nascè, A; Campion, D; Cantamessa, A; Carucci, P; Bugianesi, E
Hepatocellular carcinoma and metabolic risk factors in a main reference center in Italy
published pages: , ISSN: , DOI:
9 2020-01-29
2018 Lucette Flandroy, Theofilos Poutahidis, Gabriele Berg, Gerard Clarke, Maria-Carlota Dao, Ellen Decaestecker, Eeva Furman, Tari Haahtela, Sébastien Massart, Hubert Plovier, Yolanda Sanz, Graham Rook
The impact of human activities and lifestyles on the interlinked microbiota and health of humans and of ecosystems
published pages: 1018-1038, ISSN: 0048-9697, DOI: 10.1016/j.scitotenv.2018.01.288
Science of The Total Environment 627 2020-01-29
2019 Ramy Younes, Elisabetta Bugianesi
NASH in Lean Individuals
published pages: 086-095, ISSN: 0272-8087, DOI: 10.1055/s-0038-1677517
Seminars in Liver Disease 39/01 2020-01-29
2018 Detlef Schuppan, Muhammad Ashfaq-Khan, Ai Ting Yang, Yong Ook Kim
Liver fibrosis: Direct antifibrotic agents and targeted therapies
published pages: 435-451, ISSN: 0945-053X, DOI: 10.1016/j.matbio.2018.04.006
Matrix Biology 68-69 2020-01-29
2018 Rosso, C.; Younes, R.; Eslam, M.; Chen, Fw.; Cucco, M.; Gaggini, M.; Coulter, S.; Carli, F.; Barbieri, C.; della Latta, V.; Abate, M. L.; Saracco, Gm.; Gastaldelli, A.; George, J.; Bugianesi, E.
Bile acids composition modulate insulin resistance in non-diabetic patients with NAFLD
published pages: , ISSN: , DOI:
21 2020-01-29
2017 Pierre Bedossa, Joan Tordjman, Judith Aron-Wisnewsky, Christine Poitou, Jean-Michel Oppert, Adriana Torcivia, Jean-Luc Bouillot, Valerie Paradis, Vlad Ratziu, Karine Clément
Systematic review of bariatric surgery liver biopsies clarifies the natural history of liver disease in patients with severe obesity
published pages: 1688-1696, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2016-312238
Gut 66/9 2020-01-29
2018 Pierantonelli, G. Svegliati-Baroni I.; Younes, R.; Rosso, C.; Rychlicki, C.; Bugianesi, E.; Gastaldelli, A.
Predisposition to diabetes is related to insulin resistance in NAFLD patients and to decreased insulin secretion in HCV patients
published pages: , ISSN: , DOI:
5 2020-01-29
2018 Sergio Rodriguez-Cuenca, Stefania Carobbio, Gwendolyn Barceló-Coblijn, Xavier Prieur, Joana Relat, Ramon Amat, Mark Campbell, Ana Rita Dias, Myriam Bahri, Sarah L. Gray, Antonio Vidal-Puig
P465L-PPARγ mutation confers partial resistance to the hypolipidaemic action of fibrates
published pages: 2339-2350, ISSN: 1462-8902, DOI: 10.1111/dom.13370
Diabetes, Obesity and Metabolism 20/10 2020-01-29
2016 Rosso, Chiara; Kazankov, K.; Marietti, Milena; Gaggini, M.; Buzzigoli, E.; Møller, H. J.; Caviglia, GIAN PAOLO; Abate, Maria Lorena; Smedile, Antonina; Saracco, Giorgio Maria; Vilstrup, H.; Gastaldelli, A.; George, J.; Grønbæk, H.; Bugianesi, Elisabetta
Hepatic macrophage activation is associated with adipose tissue insulin resistance in non-diabetic patients with Non-Alcoholic Fatty Liver Disease
published pages: , ISSN: , DOI:
12 2020-01-29
2019 Geoff Farrell, Jörn M. Schattenberg, Isabelle Leclercq, Matthew M. Yeh, Robert Goldin, Narci Teoh, Detlef Schuppan
Mouse Models of Nonalcoholic Steatohepatitis: Toward Optimization of Their Relevance to Human Nonalcoholic Steatohepatitis
published pages: 2241-2257, ISSN: 0270-9139, DOI: 10.1002/hep.30333
Hepatology 69/5 2020-01-29
2019 Konstantin Kazankov, Simon Mark Dahl Jørgensen, Karen Louise Thomsen, Holger Jon Møller, Hendrik Vilstrup, Jacob George, Detlef Schuppan, Henning Grønbæk
The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
published pages: 145-159, ISSN: 1759-5045, DOI: 10.1038/s41575-018-0082-x
Nature Reviews Gastroenterology & Hepatology 16/3 2020-01-29
2017 Panu K. Luukkonen, You Zhou, Elina Isokuortti, Marja Leivonen, Anne Juuti, Antti Hakkarainen, Marju Orho-Melander, Nina Lundbom, Vesa M. Olkkonen, Riitta Lassila, Hannele Yki-Järvinen, Susanna Lallukka
Obesity/insulin resistance rather than liver fat increases coagulation factor activities and expression in humans
published pages: 286-294, ISSN: 0340-6245, DOI: 10.1160/TH16-09-0716
Thrombosis and Haemostasis 117/02 2019-12-17
2017 Amalia Gastaldelli, Melania Gaggini, Ralph DeFronzo
Glucose kinetics
published pages: 300-309, ISSN: 1363-1950, DOI: 10.1097/MCO.0000000000000384
Current Opinion in Clinical Nutrition and Metabolic Care 20/4 2019-12-17
2016 Tuulia Hyötyläinen, Livnat Jerby, Elina M. Petäjä, Ismo Mattila, Sirkku Jäntti, Petri Auvinen, Amalia Gastaldelli, Hannele Yki-Järvinen, Eytan Ruppin, Matej Orešič
Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease
published pages: 8994, ISSN: 2041-1723, DOI: 10.1038/ncomms9994
Nature Communications 7 2019-12-17
2016 Morten A. Karsdal, Kim Henriksen, Mette Juul Nielsen, Inger Byrjalsen, Diana J. Leeming, Stephen Gardner, Zachary Goodman, Keyur Patel, Aleksander Krag, Claus Christiansen, Detlef Schuppan
Fibrogenesis assessed by serological type III collagen formation identifies patients with progressive liver fibrosis and responders to a potential antifibrotic therapy
published pages: G1009-G1017, ISSN: 0193-1857, DOI: 10.1152/ajpgi.00283.2016
American Journal of Physiology-Gastrointestinal and Liver Physiology 311/6 2019-12-17
2017 B D Kayser, M Lhomme, M C Dao, F Ichou, J-L Bouillot, E Prifti, A Kontush, J-M Chevallier, J Aron-Wisnewsky, I Dugail, K Clément
Serum lipidomics reveals early differential effects of gastric bypass compared with banding on phospholipids and sphingolipids independent of differences in weight loss
published pages: 917-925, ISSN: 0307-0565, DOI: 10.1038/ijo.2017.63
International Journal of Obesity 41/6 2019-12-17
2017 Benedetta Donati, Paola Dongiovanni, Stefano Romeo, Marica Meroni, Misti McCain, Luca Miele, Salvatore Petta, Silvia Maier, Chiara Rosso, Laura De Luca, Ester Vanni, Stefania Grimaudo, Renato Romagnoli, Fabio Colli, Flaminia Ferri, Rosellina Margherita Mancina, Paula Iruzubieta, Antonio Craxi, Anna Ludovica Fracanzani, Antonio Grieco, Stefano Ginanni Corradini, Alessio Aghemo, Massimo Colombo, Giorgio Soardo, Elisabetta Bugianesi, Helen Reeves, Quentin M. Anstee, Silvia Fargion, Luca Valenti
MBOAT7 rs641738 variant and hepatocellular carcinoma in non-cirrhotic individuals
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-04991-0
Scientific Reports 7/1 2019-12-17
2018 Melania Gaggini, Fabrizia Carli, Chiara Rosso, Emma Buzzigoli, Milena Marietti, Veronica Della Latta, Demetrio Ciociaro, Maria Lorena Abate, Roberto Gambino, Maurizio Cassader, Elisabetta Bugianesi, Amalia Gastaldelli
Altered amino acid concentrations in NAFLD: Impact of obesity and insulin resistance
published pages: 145-158, ISSN: 0270-9139, DOI: 10.1002/hep.29465
Hepatology 67/1 2019-12-17
2017 Elina Isokuortti, You Zhou, Markku Peltonen, Elisabetta Bugianesi, Karine Clement, Dominique Bonnefont-Rousselot, Jean-Marc Lacorte, Amalia Gastaldelli, Detlef Schuppan, Jörn M. Schattenberg, Antti Hakkarainen, Nina Lundbom, Pekka Jousilahti, Satu Männistö, Sirkka Keinänen-Kiukaanniemi, Juha Saltevo, Quentin M. Anstee, Hannele Yki-Järvinen
Use of HOMA-IR to diagnose non-alcoholic fatty liver disease: a population-based and inter-laboratory study
published pages: 1873-1882, ISSN: 0012-186X, DOI: 10.1007/s00125-017-4340-1
Diabetologia 60/10 2019-12-17
2018 Marie Boyle, Steven Masson, Quentin M. Anstee
The bidirectional impacts of alcohol consumption and the metabolic syndrome: Cofactors for progressive fatty liver disease
published pages: 251-267, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2017.11.006
Journal of Hepatology 68/2 2019-12-17
2017 Shabnam Shalapour, Xue-Jia Lin, Ingmar N. Bastian, John Brain, Alastair D. Burt, Alexander A. Aksenov, Alison F. Vrbanac, Weihua Li, Andres Perkins, Takaji Matsutani, Zhenyu Zhong, Debanjan Dhar, Jose A. Navas-Molina, Jun Xu, Rohit Loomba, Michael Downes, Ruth T. Yu, Ronald M. Evans, Pieter C. Dorrestein, Rob Knight, Christopher Benner, Quentin M. Anstee, Michael Karin
Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity
published pages: 340-345, ISSN: 0028-0836, DOI: 10.1038/nature24302
Nature 551/7680 2019-12-17
2018 Elisabetta Morello, Salvatore Sutti, Beatrice Foglia, Erica Novo, Stefania Cannito, Claudia Bocca, Martina Rajsky, Stefania Bruzzì, Maria Lorena Abate, Chiara Rosso, Cristina Bozzola, Ezio David, Elisabetta Bugianesi, Emanuele Albano, Maurizio Parola
Hypoxia-inducible factor 2α drives nonalcoholic fatty liver progression by triggering hepatocyte release of histidine-rich glycoprotein
published pages: 2196-2214, ISSN: 0270-9139, DOI: 10.1002/hep.29754
Hepatology 67/6 2019-12-17
2017 Jake P. Mann, Quentin M. Anstee
NAFLD: PNPLA3 and obesity: a synergistic relationship in NAFLD
published pages: 506-507, ISSN: 1759-5045, DOI: 10.1038/nrgastro.2017.74
Nature Reviews Gastroenterology & Hepatology 14/9 2019-12-17
2017 Panu K. Luukkonen, You Zhou, P.A. Nidhina Haridas, Om P. Dwivedi, Tuulia Hyötyläinen, Ashfaq Ali, Anne Juuti, Marja Leivonen, Taru Tukiainen, Linda Ahonen, Emma Scott, Jeremy M. Palmer, Johanna Arola, Marju Orho-Melander, Petter Vikman, Quentin M. Anstee, Vesa M. Olkkonen, Matej Orešič, Leif Groop, Hannele Yki-Järvinen
Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD
published pages: 128-136, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2017.02.014
Journal of Hepatology 67/1 2019-12-17
2015 Hannele Yki-Järvinen
Nutritional Modulation of Non-Alcoholic Fatty Liver Disease and Insulin Resistance
published pages: 9127-9138, ISSN: 2072-6643, DOI: 10.3390/nu7115454
Nutrients 7/11 2019-12-17
2017 Zobair Younossi, Quentin M. Anstee, Milena Marietti, Timothy Hardy, Linda Henry, Mohammed Eslam, Jacob George, Elisabetta Bugianesi
Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention
published pages: 11-20, ISSN: 1759-5045, DOI: 10.1038/nrgastro.2017.109
Nature Reviews Gastroenterology & Hepatology 15/1 2019-12-17
2018 Detlef Schuppan, Rambabu Surabattula, Xiao Yu Wang
Determinants of fibrosis progression and regression in NASH
published pages: 238-250, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2017.11.012
Journal of Hepatology 68/2 2019-12-17
2017 M.A. Karsdal, S.H. Nielsen, D.J. Leeming, L.L. Langholm, M.J. Nielsen, T. Manon-Jensen, A. Siebuhr, N.S. Gudmann, S. Rønnow, J.M. Sand, S.J. Daniels, J.H. Mortensen, D. Schuppan
The good and the bad collagens of fibrosis – Their role in signaling and organ function
published pages: 43-56, ISSN: 0169-409X, DOI: 10.1016/j.addr.2017.07.014
Advanced Drug Delivery Reviews 121 2019-12-17
2017 Zoe Hall, Nicholas J. Bond, Tom Ashmore, Francis Sanders, Zsuzsanna Ament, Xinzhu Wang, Andrew J. Murray, Elena Bellafante, Sam Virtue, Antonio Vidal-Puig, Michael Allison, Susan E. Davies, Albert Koulman, Michele Vacca, Julian L. Griffin
Lipid zonation and phospholipid remodeling in nonalcoholic fatty liver disease
published pages: 1165-1180, ISSN: 0270-9139, DOI: 10.1002/hep.28953
Hepatology 65/4 2019-12-17
2016 Elina Petäjä, Hannele Yki-Järvinen
Definitions of Normal Liver Fat and the Association of Insulin Sensitivity with Acquired and Genetic NAFLD—A Systematic Review
published pages: 633, ISSN: 1422-0067, DOI: 10.3390/ijms17050633
International Journal of Molecular Sciences 17/5 2019-12-17
2018 Ramy Younes, Elisabetta Bugianesi
Should we undertake surveillance for HCC in patients with NAFLD?
published pages: 326-334, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2017.10.006
Journal of Hepatology 68/2 2019-12-17
2016 Stuart McPherson, Tim Hardy, Jean-Francois Dufour, Salvatore Petta, Manuel Romero-Gomez, Mike Allison, Claudia P Oliveira, Sven Francque, Luc Van Gaal, Jörn M Schattenberg, Dina Tiniakos, Alastair Burt, Elisabetta Bugianesi, Vlad Ratziu, Christopher P Day, Quentin M Anstee
Age as a Confounding Factor for the Accurate Non-Invasive Diagnosis of Advanced NAFLD Fibrosis
published pages: 740-751, ISSN: 0002-9270, DOI: 10.1038/ajg.2016.453
The American Journal of Gastroenterology 112/5 2019-12-17
2016 Panu K. Luukkonen, You Zhou, Tuulia Hyötyläinen, Marja Leivonen, Johanna Arola, Marju Orho-Melander, Matej Orešič, Hannele Yki-Järvinen
The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans
published pages: 1263-1265, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2016.07.045
Journal of Hepatology 65/6 2019-12-17
2017 Amalia Gastaldelli, Melania Gaggini, Ralph A. DeFronzo
Role of Adipose Tissue Insulin Resistance in the Natural History of Type 2 Diabetes: Results From the San Antonio Metabolism Study
published pages: 815-822, ISSN: 0012-1797, DOI: 10.2337/db16-1167
Diabetes 66/4 2019-12-17
2016 Elina M. Petäjä, You Zhou, Marika Havana, Antti Hakkarainen, Nina Lundbom, Jarkko Ihalainen, Hannele Yki-Järvinen
Phosphorylated IGFBP-1 as a non-invasive predictor of liver fat in NAFLD
published pages: , ISSN: 2045-2322, DOI: 10.1038/srep24740
Scientific Reports 6/1 2019-12-17
2017 Leon A Adams, Quentin M Anstee, Herbert Tilg, Giovanni Targher
Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases
published pages: 1138-1153, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2017-313884
Gut 66/6 2019-12-17
2017 Susanna Lallukka, Sanja Sädevirta, Markus T. Kallio, Panu K. Luukkonen, You Zhou, Antti Hakkarainen, Nina Lundbom, Marju Orho-Melander, Hannele Yki-Järvinen
Predictors of Liver Fat and Stiffness in Non-Alcoholic Fatty Liver Disease (NAFLD) – an 11-Year Prospective Study
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-14706-0
Scientific Reports 7/1 2019-12-17
2016 Chiara Rosso, Lavinia Mezzabotta, Melania Gaggini, Federico Salomone, Roberto Gambino, Andrea Marengo, Francesca Saba, Ester Vanni, Rami I.K. Jouness, Chiara Saponaro, Emma Buzzigoli, Gian Paolo Caviglia, Maria Lorena Abate, Antonina Smedile, Mario Rizzetto, Maurizio Cassader, Amalia Gastaldelli, Elisabetta Bugianesi
Peripheral insulin resistance predicts liver damage in nondiabetic subjects with nonalcoholic fatty liver disease
published pages: 107-116, ISSN: 0270-9139, DOI: 10.1002/hep.28287
Hepatology 63/1 2019-12-17
2015 Ann Daly, Christopher Day, Quentin Anstee
Genetics of Alcoholic Liver Disease
published pages: 361-374, ISSN: 0272-8087, DOI: 10.1055/s-0035-1567832
Seminars in Liver Disease 35/04 2019-12-17
2016 Timothy Hardy, Fiona Oakley, Quentin M. Anstee, Christopher P. Day
Nonalcoholic Fatty Liver Disease: Pathogenesis and Disease Spectrum
published pages: 451-496, ISSN: 1553-4006, DOI: 10.1146/annurev-pathol-012615-044224
Annual Review of Pathology: Mechanisms of Disease 11/1 2019-12-17
2015 Michael Allison, Julian Griffin, Michele Vacca, Antonio Vidal-Puig
Fatty Acid and Glucose Sensors in Hepatic Lipid Metabolism: Implications in NAFLD
published pages: 250-261, ISSN: 0272-8087, DOI: 10.1055/s-0035-1562945
Seminars in Liver Disease 35/03 2019-12-17
2017 Morten A. Karsdal, Kim Henriksen, Federica Genovese, Diana J. Leeming, Mette J. Nielsen, Bente J. Riis, Claus Christiansen, Inger Byrjalsen, Detlef Schuppan
Serum endotrophin identifies optimal responders to PPARγ agonists in type 2 diabetes
published pages: 50-59, ISSN: 0012-186X, DOI: 10.1007/s00125-016-4094-1
Diabetologia 60/1 2019-12-17
2015 Christopher Day, Quentin Anstee
The Genetics of Nonalcoholic Fatty Liver Disease: Spotlight on PNPLA3 and TM6SF2
published pages: 270-290, ISSN: 0272-8087, DOI: 10.1055/s-0035-1562947
Seminars in Liver Disease 35/03 2019-12-17
2016 M. Noureddin, Q. M. Anstee, R. Loomba
Review article: emerging anti-fibrotic therapies in the treatment of non-alcoholic steatohepatitis
published pages: 1109-1123, ISSN: 0269-2813, DOI: 10.1111/apt.13620
Alimentary Pharmacology & Therapeutics 43/11 2019-12-17
2016 Quentin M. Anstee, Devanshi Seth, Christopher P. Day
Genetic Factors That Affect Risk of Alcoholic and Nonalcoholic Fatty Liver Disease
published pages: 1728-1744.e7, ISSN: 0016-5085, DOI: 10.1053/j.gastro.2016.01.037
Gastroenterology 150/8 2019-12-17
2016 Timothy Hardy, Mujdat Zeybel, Christopher P Day, Christian Dipper, Steven Masson, Stuart McPherson, Elsbeth Henderson, Dina Tiniakos, Steve White, Jeremy French, Derek A Mann, Quentin M Anstee, Jelena Mann
Plasma DNA methylation: a potential biomarker for stratification of liver fibrosis in non-alcoholic fatty liver disease
published pages: gutjnl-2016-3115, ISSN: 0017-5749, DOI: 10.1136/gutjnl-2016-311526
Gut 0, 1-8 2019-12-17

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The information about "EPOS" are provided by the European Opendata Portal: CORDIS opendata.

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