Explore the words cloud of the BIND project. It provides you a very rough idea of what is the project "BIND" about.
The following table provides information about the project.
UNIVERSITY COLLEGE LONDON
|Coordinator Country||United Kingdom [UK]|
|Total cost||6˙716˙325 €|
|EC max contribution||6˙666˙325 € (99%)|
1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
|Duration (year-month-day)||from 2020-01-01 to 2023-12-31|
Take a look of project's partnership.
|1||UNIVERSITY COLLEGE LONDON||UK (LONDON)||coordinator||1˙733˙428.00|
|2||ACADEMISCH ZIEKENHUIS LEIDEN||NL (LEIDEN)||participant||1˙014˙553.00|
|3||CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS||FR (PARIS)||participant||498˙179.00|
|4||UNIVERSITE DE VERSAILLES SAINT-QUENTIN-EN-YVELINES.||FR (VERSAILLES)||participant||472˙675.00|
|5||UNIVERSITY OF NEWCASTLE UPON TYNE||UK (NEWCASTLE UPON TYNE)||participant||470˙980.00|
|6||CONSORZIO FUTURO IN RICERCA||IT (FERRARA)||participant||334˙000.00|
|7||STICHTING KEMPENHAEGHE||NL (HEEZE)||participant||304˙437.00|
|8||REGION HOVEDSTADEN||DK (HILLEROD)||participant||285˙207.00|
|9||TRANSPHARMATION IRELAND LTD||IE (DUBLIN)||participant||272˙445.00|
|10||THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN||IE (DUBLIN)||participant||253˙508.00|
|11||UNIVERSITA CATTOLICA DEL SACRO CUORE||IT (MILANO)||participant||183˙500.00|
|12||UNIVERSIDAD COMPLUTENSE DE MADRID||ES (MADRID)||participant||179˙125.00|
|13||IMAGINE INSTITUT DES MALADIES GENETIQUES NECKER ENFANTS MALADES FONDATION||FR (PARIS 15)||participant||166˙250.00|
|14||STICHTING UNITED PARENT PROJECTS MUSCULAR DYSTROPHY||NL (VEENENDAAL)||participant||165˙687.00|
|15||STICHTING DUCHENNE DATA FOUNDATION||NL (BERGEN OP ZOOM)||participant||137˙687.00|
|16||SYNTHENA AG||CH (BERN)||participant||100˙000.00|
|17||PEPGEN LIMITED||UK (OXFORD)||participant||53˙563.00|
|18||GREAT ORMOND STREET HOSPITAL FOR CHILDREN NHS FOUNDATION TRUST||UK (LONDON)||participant||41˙096.00|
|19||NATIONAL CENTER OF NEUROLOGY AND PSYCHIATRY||JP (KODAIRA TOKYO)||participant||0.00|
Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy in childhood, with more than 25,000 patients in Europe. It is due to mutations in the DMD gene that preclude the production of the protein dystrophin. In addition to the progressive muscle weakness, 50% of affected individuals have debilitating central nervous system (CNS) co-morbidities, including intellectual disability, neurodevelopmental problems encompassing autism, Attention Deficit Hyperactivity Disorder and Obsessive Compulsive Disorder. These co-morbidities are due to the deficiency of multiple dystrophin isoforms in brain whose expression is differentially affected by the site of the DMD mutation. They represent a major obstacle for patients to live a fully independent life. Current therapies do not address these co-morbidities. The postnatal restoration of one dystrophin isoform using genetic therapies in the DMD mouse model improves the neurobehavioral phenotype. This raises the exciting possibility that some of the CNS co-morbidities could improve with genetic therapies in patients. We need to address several knowledge gaps before considering clinical applications of these therapies: i. dystrophin isoforms localisation in the CNS; ii. which of the neurobehavioural features of the dystrophic mice improve after dystrophin restoration, and circuitries involved; iii. deep phenotype patients to define robust outcome measures. This project developed in partnership with advocacy groups, meets gender criteria and offers for the first time insight into how dystrophins’ affect CNS function, and on the reversibility of the DMD CNS co-morbidities, providing essential information to the field of neurodevelopmental disorders, and for other syndromes arising from dystrophin associated proteins. Our efforts to develop novel therapies that can cross the blood brain barrier could be transformative for the field of neurodegeneration and neurodevelopmental disorders.
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The information about "BIND" are provided by the European Opendata Portal: CORDIS opendata.