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SUMCASTEC SIGNED

Semiconductor-based Ultrawideband Micromanipulation of CAncer STEm Cells

Total Cost €

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EC-Contrib. €

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Partnership

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 SUMCASTEC project word cloud

Explore the words cloud of the SUMCASTEC project. It provides you a very rough idea of what is the project "SUMCASTEC" about.

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Project "SUMCASTEC" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE DE LIMOGES 

Organization address
address: François Mitterrand 33
city: Limoges
postcode: 87032
website: www.unilim.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Project website http://www.sumcastec.eu
 Total cost 3˙978˙517 €
 EC max contribution 3˙978˙517 € (100%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-1-2016-2017
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE DE LIMOGES FR (Limoges) coordinator 994˙946.00
2    BANGOR UNIVERSITY UK (BANGOR) participant 705˙050.00
3    AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE IT (ROMA) participant 690˙647.00
4    IHP GMBH - INNOVATIONS FOR HIGH PERFORMANCE MICROELECTRONICS/LEIBNIZ-INSTITUT FUER INNOVATIVE MIKROELEKTRONIK DE (FRANKFURT ODER) participant 610˙250.00
5    CREO MEDICAL LIMITED UK (CHEPSTOW GWENT) participant 530˙906.00
6    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) participant 446˙717.00

Map

 Project objective

SUMCASTEC explores radically new approach for cancer stem cells (CSCs) real time isolation (i.e. within minutes vs current 40 days) and neutralization. A novel micro-optofluidic lab-on-chip (LOC) platform will be developed through a joint and iterative effort by biologists, clinicians and engineers. For the first time, a single LOC will be capable of delivering ultra-wide broadband radiation to compare cell spectral signatures, image subcellular features, and hence modulate CSCs microenvironment conditions with unprecedented space and time resolution. It will be driven to isolate CSCs from heterogeneous differentiated and stem cell populations, and force CSCs differentiation, ultimately inducing sensitivity to anticancer treatments. Extensive in vitro and in vivo testing along with biophysical modelling will validate the approach and establish the proof-of-principle within the project life-time, while laying the groundwork for further development of future electrosurgical tools that will be capable CSCs neutralization in tissue. This will not only establish a new line of treatment for brain cancers such as Glioblastoma Multiforme and Medulloblastoma, whose initiation and recurrence were linked to CSCs, and that claim tremendous human and economic tolls, worldwide; it will also push the current boundaries of microbiological analysis by enabling microenvironment characterization/manipulation and real-time ionic channels monitoring without cytotoxic patch-clamping or electron microscopy. By investing in efforts such as SUMCASTEC’s, Europe will stand at the forefront of global biomedical innovation and push through a similar miniaturization trend as the one that propelled mobile communications, yet with much deeper societal impact. All the required competences are gathered within this consortium. The ambitious objectives of the project are planned over 42 months with a requested grant of 3 978 517,5 €.

 Deliverables

List of deliverables.
Scientific action check meeting M24 Documents, reports 2019-05-02 16:15:29
Stakeholders management workshop Websites, patent fillings, videos etc. 2019-05-02 16:14:23
Data Management Plan Open Research Data Pilot 2019-05-02 16:15:25
Public Website Websites, patent fillings, videos etc. 2019-05-02 16:15:26
List of ICT system specifications Documents, reports 2019-05-02 16:15:29
Minutes of the Steering Committee meetings at M6 Documents, reports 2019-05-02 16:14:58
Project identity set (logo, brochure…) Websites, patent fillings, videos etc. 2019-05-02 16:15:29
In vitro CSCs isolation and characterization in human GBM and MB models Documents, reports 2019-05-02 16:15:35
Minutes of the Steering Committee meetings at M12 Documents, reports 2019-05-02 16:15:27
Minutes of the Steering Committee meeting at M18 Documents, reports 2019-05-02 16:14:24
Biological protocols Documents, reports 2019-05-02 16:14:59
Minutes of the Steering Committee meeting at M24 Documents, reports 2019-05-02 16:15:25
Scientific action check meeting M12 Documents, reports 2019-05-02 16:14:30

Take a look to the deliverables list in detail:  detailed list of SUMCASTEC deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 B. Cetindogan, ,M. Inac, A. Goritz, M. Wietstruck, C. Baristiran-Kaynak, C. Palego, A. Pothier, ,M. Kaynak
BiCMOS Microfluidic Microwave Platform for Biological Cell Sensing and Manipulation
published pages: , ISSN: , DOI:
2017 IEEE MTT-S International Microwave Symposium (IMS) Workshop on Thermal vs non-ther 2019-06-11
2017 C. Palego, C. Hancock, A. Porch, M. Kaynak
BiCMOS/microfluidics lab-on-chip
published pages: , ISSN: , DOI:
2017 Engineering Wales Conference 2019-06-11
2017 C. Hancock
Advanced RF, Microwave and Millimeter Wave Energy Based Systemsto Address A Range of Unmet and Growing Clinical Needs
published pages: , ISSN: , DOI:
2017 Workshop IEEE MTT-S International Microwave Symposium (IMS) Workshop on Thermal vs non-ther 2019-06-11
2017 A. Pothier, C.Dalmay, F. Hjeij P. Blondy, F.Lalloué, B.Bessette, M.Kaynak, C. Palego
Dielectric Spectroscopy and RF and Microwave Passive Microsystems for Biological Applications and Discrimination of Cells
published pages: , ISSN: , DOI:
2017 IEEE MTT-S International Microwave Symposium (IMS) 2019-06-11
2019 I. V. Minin, O. V. Minin, G. M. Katyba, N. V. Chernomyrdin, V. N. Kurlov, K. I. Zaytsev, L. Yue, Z. Wang, D. N. Christodoulides
Experimental observation of a photonic hook
published pages: 31105, ISSN: 0003-6951, DOI: 10.1063/1.5065899
Applied Physics Letters 114/3 2019-05-23
2018 Gamal, Wesam; Pinto, Rosanna; Tanori, Mirella; Casciati, Arianna; Mancuso, Mariateresa; Persano, Luca; Viola, Giampietro; Saada, Sofiane; Bessette, Barbara; Lalloue, Fabrice; Pothier, Arnaud; Palego, Cristiano; Merla, Caterina
Permittivity measurements of brain cancer cell solutions: towards the electric characterisation of single cancer stem cells, 1st EMF-Med World Conference on Biomedical Applications
published pages: , ISSN: , DOI: 10.5281/zenodo.1443523
2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med) 2019-05-23
2018 C. Palego
Tiny chips: from bee wearable electronics to cancer stem cells seek and destroy
published pages: , ISSN: , DOI:
2018 Center for High Frequency Electronics Seminar 2019-03-11
2018 S. Saada , R. Manczak, B. Bessette, G.Begaud, C. Dalmay, S. Battu,P.Blondy, M. Inac, C. Baristiran Kaynak, M. Kaynak, C.Palego, M.0 Jauberteau, A. Pothier, F.Lalloue
Discrimination of Glioblastoma Cancer Stem Cells by their UHF-Dielectrophoresis Crossover Frequency
published pages: , ISSN: , DOI:
2018 International Conference on Cancer Stem Cells and Oncology Research 2019-03-11
2018 S Saada
Isolation and characterization of the Cancer Stem cells (CSCs): one question, many answers
published pages: , ISSN: , DOI:
2018 Workshop on EM field interaction with biological tissues for cancer and regenerative medicine 2019-03-11
2018 G. Begaud; B. Bessette; S. Saad; R. Manczak; M. Mancuso; F. Lalloue; C. Dalmay; A Pothier; P.J.P. Cardot; S. Battu
Strategy for brain stem cell sorting with SDFF
published pages: , ISSN: , DOI:
2018 International Symposium on Field and Flow Based Separations 2019-03-11
2018 R Manzac, A Pothier. C. Dalamy, P. Blondy, S. Saada, F. Lalloue
On-chip Flow Cell Sorting System Based on High frequency Dielectrophoresis implemented on CMOS technology
published pages: , ISSN: , DOI:
2018 Workshop of GDR Micronanofluidics 2019-03-12
2018 S. Saada , R. Manczak, B. Bessette, G.Begaud, C. Dalmay, S. Battu,P.Blondy, M. Inac, C. Baristiran Kaynak, M. Kaynak, C.Palego, M.0 Jauberteau, A. Pothier, F.Lalloue
Glioblastoma Cancer Stem like Cells discrimination by UHF-Dielectrophoresis Crossover Frequency
published pages: , ISSN: , DOI:
2018 Workshop of French Canceropole GSO 2019-03-11
2018 I. Davies
Electro-permeabilization of isolated cancer stem cells with a push-pull configuration of high power MOSFETs
published pages: , ISSN: , DOI:
2018 Workshop on EM field interaction with biological tissues for cancer and regenerative medicine 2019-03-12
2018 W Ramal
Dielectric characterization of brain cancer cell lines
published pages: , ISSN: , DOI:
2018 Workshop on EM field interaction with biological tissues for cancer and regenerative medicine 2019-03-11
2019 T. Provent, R. Manczak, S. Saada, C.Dalmay, B. Bessette, P. Blondy, G. Begaud, S. Battu, M.O. Jauberteau, F. Lalloué, A. Pothier
Ultra-High Frequencies continuous biological cell sorting based on repulsive and low dielectrophoresis forces,
published pages: , ISSN: , DOI:
2019 IEEE MTT-S International Microwave Symposium (IMS) 2019-03-11
2019 Mirella Tanori, Arianna Casciati, Barbara Tanno, Paola Giardullo, Alessandro Zambotti, Carmela Marino, Caterina Merla, Mariateresa Mancuso
New therapeutic strategy for medulloblastoma: µs pulse electric fields exposure targeting cancer stem cells to promote radiosensitization
published pages: , ISSN: , DOI:
2019 International Conference on Radiation in Various Fields of Research (RAD 2019) 2019-03-11
2018 C. Merla
Novel and versatile instrumentation for electro-manipulation of cancer stem cells
published pages: , ISSN: , DOI:
2018 BioEM 2018 The Joint Annual Meeting of The Bioelectromagnetics Society and the European BioElectromagnetics Association 2019-03-12
2018 C. Merla
Ultra-short pulsed electric fields: a first study on cancer stem cells
published pages: , ISSN: , DOI:
2018 Workshop on EM field interaction with biological tissues for cancer and regenerative medicine 2019-03-11
2018 A Pothier
BiCMOS integrated microfluidic cell sorting platform for CSC cell study
published pages: , ISSN: , DOI:
2018 Workshop on EM field interaction with biological tissues for cancer and regenerative medicine 2019-03-11
2018 A. Pothier
Detection and Neutralization of Cancerous Stem Cells with lab on chip
published pages: , ISSN: , DOI:
2018 Workshop of GDR Happybio 06-08 November 201 2019-03-12
2019 Remi Manczak, Sofiane Saada, Thomas Provent, Claire Dalmay, Barbara Bessette, Gaelle Begaud, Serge Battu, Pierre Blondy, Marie-Odile Jauberteau, Canan Baristiran Kaynak, Mehmet Kaynak, Cristiano Palego, Fabrice Lalloue, Arnaud Pothier
UHF-Dielectrophoresis Crossover Frequency as a New Marker for Discrimination of Glioblastoma Undifferentiated Cells
published pages: 1-1, ISSN: 2469-7249, DOI: 10.1109/jerm.2019.2895539
IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology 2019-03-11
2018 Gamal, Wesam; Pinto, Rosanna; Tanori, Mirella; Casciati, Arianna; Mancuso, Mariateresa; Persano, Luca; Viola, Giampietro; Saada, Sofiane; Bessette, Barbara; Lalloue, Fabrice; Pothier, Arnaud; Palego, Cristiano; Merla, Caterina
Permittivity measurements of brain cancer cell solutions: towards the electric characterisation of single cancer stem cells, 1st EMF-Med World Conference on Biomedical Applications
published pages: , ISSN: , DOI: 10.5281/zenodo.1443523
2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med) 2019-02-27

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