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CARBAZYMES

Sustainable industrial processes based on a C-C bond-forming enzyme platform

Total Cost €

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EC-Contrib. €

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Partnership

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 CARBAZYMES project word cloud

Explore the words cloud of the CARBAZYMES project. It provides you a very rough idea of what is the project "CARBAZYMES" about.

evolve    detected    evolution    industry    apis    bn    technologies    global    replace    stages    chemicals    biotec3    academia    unmistakably    drive    competitiveness    platform    worth    pharmaceutical    massive    jobs    enzymes    market    comprising    biocatalytic    bulk    capacity    aligned    pursue    participation    intersectoral    footprints    industrial    bioprocess    enzyme    viability    2014    inter    mostly    interdisciplinary    unexplored    characterization    forming    demonstration    life    sites    facilities    timelines    screening    spanning    reactions    panels    synthesis    trls    actions    largely    organic    powerful    carbazymes    lyases    microreactor    chemical    synergistic    disciplinary    markets    intensive    bond    broad    resource    social    interests    commercial    accomplished    qualified    ensures    economic    platforms    reaction    corresponding    energy    tool    environmental    operate    50    100l    lack    innovation    scope    heart    cycle    assembling    enforcing    types   

Project "CARBAZYMES" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITAT DARMSTADT 

Organization address
address: KAROLINENPLATZ 5
city: DARMSTADT
postcode: 64289
website: www.tu-darmstadt.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.carbazymes.com/
 Total cost 9˙251˙355 €
 EC max contribution 8˙202˙966 € (89%)
 Programme 1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
 Code Call H2020-LEIT-BIO-2014-1
 Funding Scheme IA
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2019-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITAT DARMSTADT DE (DARMSTADT) coordinator 1˙469˙606.00
2    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) participant 1˙145˙190.00
3    UNIVERSIDAD AUTONOMA DE MADRID ES (MADRID) participant 786˙375.00
4    RIJKSUNIVERSITEIT GRONINGEN NL (GRONINGEN) participant 726˙452.00
5    TECHNISCHE UNIVERSITAET BRAUNSCHWEIG DE (BRAUNSCHWEIG) participant 677˙018.00
6    SVEUCILISTE U ZAGREBU FAKULTET KEMIJSKOG INZENJERSTVA I TEHNOLOGIJE HR (ZAGREB) participant 544˙260.00
7    EVONIK CREAVIS GMBH DE (ESSEN) participant 478˙625.00
8    BIO-PRODICT BV NL (NIJMEGEN) participant 463˙736.00
9    INSTITUT UNIV DE CIENCIA I TECNOLOGIA SA ES (MOLLET DEL VALLES) participant 416˙325.00
10    ALBERT-LUDWIGS-UNIVERSITAET FREIBURG DE (FREIBURG) participant 412˙500.00
11    PROZOMIX LIMITED UK (HALTWHISTLE) participant 384˙892.00
12    ENZYMICALS AG DE (GREIFSWALD) participant 380˙800.00
13    BIOCHEMIZE SL ES (BARCELONA) participant 207˙987.00
14    SUSTAINABLE MOMENTUM SL ES (LAS PALMAS DE GRAN CANARIA) participant 109˙200.00
15    EVONIK INDUSTRIES AG DE (ESSEN) participant 0.00

Map

 Project objective

C-C bond forming reactions are at the heart of industrial organic synthesis, but remain largely unexplored due to long development timelines and the lack of broad biocatalytic reaction platforms. CARBAZYMES addresses these challenges by assembling an interdisciplinary and intersectoral consortium as a powerful synergistic tool to promote innovation in the field of biocatalytic C-C bond formation at large scale, and thus the global competitiveness of the European chemical and pharmaceutical industry. The proposed consortium, with 50% industrial participation, represents academia but also commercial interests in different stages of the research-to-market process. This top-down approach, together with a life-cycle innovation approach ensures an industrial drive to the project. Clearly aligned with the scope of topic BIOTEC3-2014, CARBAZYMES will pursue the biocatalytic synthesis (spanning TRLs 5-7) of 4 APIs and 3 bulk chemicals –corresponding to market needs detected by the industrial partners in the Consortium. This will be accomplished through an inter-disciplinary approach which includes: i) a broad platform of 4 types of unique C-C bond-forming enzymes, mostly lyases; ii) the capacity to rapidly evolve enzymes to operate under industrial conditions by means of novel enzyme panels and massive screening methods; iii) application of microreactor technology for bioprocess characterization; iv) demonstration actions comprising technical (up to 100L) and economic viability studies carried out by industrial partners. CARBAZYMES unmistakably aims to have social and economic impact by addressing markets worth bn €, developing enzyme evolution technologies beyond the state of the art and creating qualified jobs and technical-scale facilities at the industrial partners’ sites. CARBAZYMES will also achieve an environmental impact by enforcing that the developed processes replace more energy and resource intensive processes, thus leading to reduced environmental footprints.

 Deliverables

List of deliverables.
International Outreach Symposium Other 2020-02-06 14:56:19
Fourth set of scientific publications Websites, patent fillings, videos etc. 2020-02-06 14:56:19
Project website Websites, patent fillings, videos etc. 2020-02-06 14:56:18
Second set of scientific publications Websites, patent fillings, videos etc. 2020-02-06 14:56:18
Publicity materials Other 2020-02-06 14:56:18
Dissemination and branding standards Websites, patent fillings, videos etc. 2020-02-06 14:56:18
First set of scientific publications Websites, patent fillings, videos etc. 2020-02-06 14:56:18
Posts, press releases, news items Websites, patent fillings, videos etc. 2020-02-06 14:56:18
Third set of scientific publications Websites, patent fillings, videos etc. 2020-02-06 14:56:18

Take a look to the deliverables list in detail:  detailed list of CARBAZYMES deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Chao Guo, Mohammad Saifuddin, Thangavelu Saravanan, Masih Sharifi, Gerrit J. Poelarends
Biocatalytic Asymmetric Michael Additions of Nitromethane to α,β-Unsaturated Aldehydes via Enzyme-bound Iminium Ion Intermediates
published pages: 4369-4373, ISSN: 2155-5435, DOI: 10.1021/acscatal.9b00780
ACS Catalysis 9/5 2020-02-06
2019 Anera Švarc, Zvjezdana Findrik Blažević, Đurđa Vasić‐Rački, Anna Szekrenyi, Wolf‐Dieter Fessner, Simon J Charnock, Ana Vrsalović Presečki
2‐Deoxyribose‐5‐phosphate aldolase from Thermotoga maritima in the synthesis of a statin side‐chain precursor: characterization, modeling and optimization
published pages: 1832-1842, ISSN: 0268-2575, DOI: 10.1002/jctb.5956
Journal of Chemical Technology & Biotechnology 94/6 2020-02-06
2018 Anders O. Magnusson, Anna Szekrenyi, Henk‐Jan Joosten, James Finnigan, Simon Charnock, Wolf‐Dieter Fessner
nanoDSF as screening tool for enzyme libraries and biotechnology development
published pages: 184-204, ISSN: 1742-464X, DOI: 10.1111/febs.14696
The FEBS Journal 286/1 2020-02-06
2018 Raquel Roldán, Karel Hernandez, Jesús Joglar, Jordi Bujons, Teodor Parella, Israel Sánchez-Moreno, Virgil Hélaine, Marielle Lemaire, Christine Guérard-Hélaine, Wolf-Dieter Fessner, Pere Clapés
Biocatalytic Aldol Addition of Simple Aliphatic Nucleophiles to Hydroxyaldehydes
published pages: 8804-8809, ISSN: 2155-5435, DOI: 10.1021/acscatal.8b02486
ACS Catalysis 8/9 2020-02-06
2018 Millán, Claudia; Sammito, Massimo; McCoy, Airlie; Nascimento, Andrey F Ziem; Petrillo, Giovanna; Oeffner, Robert; Domínguez-Gil, Teresa; Hermoso, Juan A; Read, Randy; Usón, Isabel
Exploiting distant homologues for phasing through the generation of compact fragments, local fold refinement and partial solution combination.
published pages: D74, 290–304, ISSN: 2059-7983, DOI: 10.17863/CAM.25122
Acta Crystallographica. Section D, Structural Biology 6 2020-02-06
2019 M. Sudar
Application of Chemical Engineering Methodology in Process Development: A Case Study of MenD-catalyzed Synthesis of 6-Cyano-4-oxohexanoic Acid
published pages: 501-510, ISSN: 0352-9568, DOI: 10.15255/cabeq.2018.1393
Chemical and Biochemical Engineering Quarterly 32/4 2020-02-06
2018 Sabrina Hampel, Jan-Patrick Steitz, Anna Baierl, Patrizia Lehwald, Luzia Wiesli, Michael Richter, Alexander Fries, Martina Pohl, Gunter Schneider, Doreen Dobritzsch, Michael Müller
Structural and Mutagenesis Studies of the Thiamine-Dependent, Ketone-Accepting YerE from Pseudomonas protegens
published pages: 2283-2292, ISSN: 1439-4227, DOI: 10.1002/cbic.201800325
ChemBioChem 19/21 2020-02-06
2019 Raquel Roldán, Karel Hernández, Jesús Joglar, Jordi Bujons, Teodor Parella, Wolf-Dieter Fessner, Pere Clapés
Aldolase-Catalyzed Asymmetric Synthesis of N-Heterocycles by Addition of Simple Aliphatic Nucleophiles to Aminoaldehydes
published pages: 361, 1–16, ISSN: 1615-4150, DOI: 10.1002/adsc.201801530
Advanced Synthesis & Catalysis Adv. Synth. Catal. 2020-02-06
2018 Sebastian Junker, Raquel Roldan, Henk-Jan Joosten, Pere Clapés, Wolf-Dieter Fessner
Complete Switch of Reaction Specificity of an Aldolase by Directed Evolution In Vitro: Synthesis of Generic Aliphatic Aldol Products
published pages: 10153-10157, ISSN: 1433-7851, DOI: 10.1002/anie.201804831
Angewandte Chemie International Edition 57/32 2020-02-06
2019 Lieuwe Biewenga, Thangavelu Saravanan, Andreas Kunzendorf, Jan-Ytzen van der Meer, Tjaard Pijning, Pieter G. Tepper, Ronald van Merkerk, Simon J. Charnock, Andy-Mark W. H. Thunnissen, Gerrit J. Poelarends
Enantioselective Synthesis of Pharmaceutically Active γ-Aminobutyric Acids Using a Tailor-Made Artificial Michaelase in One-Pot Cascade Reactions
published pages: 1503-1513, ISSN: 2155-5435, DOI: 10.1021/acscatal.8b04299
ACS Catalysis 9/2 2020-02-06
2019 Elia Calderini, Julia Wessel, Philipp Süss, Patrick Schrepfer, Rainer Wardenga, Anett Schallmey
Selective Ring‐Opening of Di‐Substituted Epoxides Catalysed by Halohydrin Dehalogenases
published pages: 2099-2106, ISSN: 1867-3880, DOI: 10.1002/cctc.201900103
ChemCatChem 11/8 2020-02-06
2016 Jan-Ytzen van der Meer, Lieuwe Biewenga, Gerrit J. Poelarends
The Generation and Exploitation of Protein Mutability Landscapes for Enzyme Engineering
published pages: , ISSN: 1439-4227, DOI: 10.1002/cbic.201600382
ChemBioChem 2020-02-06
2017 Karel Hernandez, Jordi Bujons, Jesús Joglar, Simon J. Charnock, Pablo Domínguez de María, Wolf Dieter Fessner, Pere Clapés
Combining Aldolases and Transaminases for the Synthesis of 2-Amino-4-hydroxybutanoic Acid
published pages: 1707-1711, ISSN: 2155-5435, DOI: 10.1021/acscatal.6b03181
ACS Catalysis 7/3 2020-02-06
2017 José Berenguer, Mario Mencía, Aurelio Hidalgo
Are in vivo selections on the path to extinction?
published pages: 46-49, ISSN: 1751-7915, DOI: 10.1111/1751-7915.12490
Microbial Biotechnology 10/1 2020-02-06
2016 Anett Schallmey, Marcus Schallmey
Recent advances on halohydrin dehalogenases—from enzyme identification to novel biocatalytic applications
published pages: 7827-7839, ISSN: 0175-7598, DOI: 10.1007/s00253-016-7750-y
Applied Microbiology and Biotechnology 100/18 2020-02-06
2018 Yen-Chi Thai, Anna Szekrenyi, Yuyin Qi, Gary W. Black, Simon J. Charnock, Wolf-Dieter Fessner
Fluorogenic kinetic assay for high-throughput discovery of stereoselective ketoreductases relevant to pharmaceutical synthesis
published pages: 1320-1326, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2017.05.024
Bioorganic & Medicinal Chemistry 26/7 2020-02-06
2018 Karel Hernández, Jesús Joglar, Jordi Bujons, Teodor Parella, Pere Clapés
Cover Picture: Nucleophile Promiscuity of Engineered Class II Pyruvate Aldolase YfaU from E. Coli (Angew. Chem. Int. Ed. 14/2018)
published pages: 3521-3521, ISSN: 1433-7851, DOI: 10.1002/anie.201802275
Angewandte Chemie International Edition 57/14 2020-02-06
2017 Karel Hernández, Ariadna Gómez, Jesús Joglar, Jordi Bujons, Teodor Parella, Pere Clapés
2-Keto-3-Deoxy- l -Rhamnonate Aldolase (YfaU) as Catalyst in Aldol Additions of Pyruvate to Amino Aldehyde Derivatives
published pages: 2090-2100, ISSN: 1615-4150, DOI: 10.1002/adsc.201700360
Advanced Synthesis & Catalysis 359/12 2020-02-06
2018 Martina Sudar, Đurđa Vasić-Rački, Michael Müller, Alexandra Walter, Zvjezdana Findrik Blažević
Mathematical model of the MenD-catalyzed 1,4-addition (Stetter reaction) of α-ketoglutaric acid to acrylonitrile
published pages: 71-80, ISSN: 0168-1656, DOI: 10.1016/j.jbiotec.2018.01.013
Journal of Biotechnology 268 2020-02-06
2018 Karel Hernández, Jesús Joglar, Jordi Bujons, Teodor Parella, Pere Clapés
Nucleophile Promiscuity of Engineered Class II Pyruvate Aldolase YfaU from E. Coli
published pages: 3645-3649, ISSN: 0044-8249, DOI: 10.1002/ange.201711289
Angewandte Chemie 130/14 2020-02-06

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