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NEURIMMUNE SIGNED

Neural regulation of immunity

Total Cost €

0

EC-Contrib. €

0

Partnership

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 NEURIMMUNE project word cloud

Explore the words cloud of the NEURIMMUNE project. It provides you a very rough idea of what is the project "NEURIMMUNE" about.

demonstrated    innervation    infections    environmental    selective    wild    neurons    sensory    paradigm    acute    vaccination    signals    insights    designed    molecular    capacity    modulation    signs    decipher    independent    complementary    functions    neurimmune    vaccine    host    adaptive    mechanisms    immune    bidirectional    perceived    convey    protective    noxious    damage    involve    question    innate    nociceptive    anatomical    implications    tackle    intradermal    inflammation    functional    defence    organisms    bases    deficits    prophylactic    mouse    tissues    local    genetic    instructs    regulatory    deficient    locally    avenues    preliminary    immunity    stimulation    pathogens    therapies    cellular    injury    pain    nociceptors    interdisciplinary    innovative    tissue    skin    exacerbated    interactions    animals    modulate    living    models    sensitivity    survival    vaccines    damaging    brain    release    systemic    nervous    depends    mediators   

Project "NEURIMMUNE" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 2˙000˙000.00

Map

 Project objective

Survival of living organisms depends on their capacity to develop defence mechanisms against environmental challenges that cause tissue damage and infections. These protective functions involve the nervous system and the immune system, two systems traditionally considered as independent. However anatomical and cellular bases for bidirectional interactions between them have been established and a new paradigm on a regulatory role of the nervous system on immune functions is emerging. Pain is one of the major signs of inflammation. Upon acute injury, inflammation or infections noxious signals are perceived by nociceptors present in tissues, such as the skin. These sensory neurons convey the damaging information to the brain and release a number of mediators locally that could modulate immunity. The goal of this project is to decipher the functional role of sensory neurons and pain sensitivity on immune responses. We will tackle this highly challenging question by studying the immune responses to vaccination in genetic mouse models in which skin innervation by nociceptors is deficient. Our preliminary results are very promising as we already demonstrated that deficits in sensory skin innervation affect both the innate and adaptive immune responses to intradermal vaccine. We will further study the cellular and molecular mechanisms involved in this local and systemic modulation of the immune response by the nervous system. As a complementary approach, we will address the role of an exacerbated pain response on immunity through the selective stimulation of nociceptive neurons in wild type animals. This interdisciplinary study is designed to provide new insights into how the nervous system instructs the immune system. Results from NEURIMMUNE are expected to open new avenues of research on the integrated host response to pathogens with important implications for the design of innovative prophylactic vaccines and therapies.

 Publications

year authors and title journal last update
List of publications.
2017 Linda Quatrini, Elisabeth Wieduwild, Sophie Guia, Claire Bernat, Nicolas Glaichenhaus, Eric Vivier, Sophie Ugolini
Host resistance to endotoxic shock requires the neuroendocrine regulation of group 1 innate lymphoid cells
published pages: 3531-3541, ISSN: 0022-1007, DOI: 10.1084/jem.20171048
The Journal of Experimental Medicine 214/12 2019-06-07

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