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The heart of stroke: Pipes, Perfusion, Parenchyma

Total Cost €


EC-Contrib. €






 HEARTOFSTROKE project word cloud

Explore the words cloud of the HEARTOFSTROKE project. It provides you a very rough idea of what is the project "HEARTOFSTROKE" about.

burden    synergy    brain    therapeutic    innovative    vast    thromboemboli    plaque    causes    evaluations    inflammatory    micro    explanation    intraplaque    vessel    created    disease    pipes    local    strategies    microinfarcts    territory    innovations    labeling    intracranial    critically    successful    myocardial    reserve    caused    stroke    led    spin    thromboembolic    biomarkers    patient    unexplained    impaired    patients    infarcts    neurodegenerative    single    haemorrhage    infarction    atherosclerotic    vasculature    societies    characterise    preventive    aorta    visualise    contrast    cardiovascular    diseases    western    detect    majority    mri    my    healthcare    arteries    designing    3ps    parenchyma    blind    neck    impairment    eye    macro    systematic    detection    arterial    coronary    macroinfarcts    enhancement    understand    noninvasive    morbidity    calcification    wall    reducing    hemodynamic    heart    pave    total    turned    perfusion   

Project "HEARTOFSTROKE" data sheet

The following table provides information about the project.


Organization address
postcode: 3584 CX

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 1˙499˙450 €
 EC max contribution 1˙499˙450 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-03-01   to  2020-02-29


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

My aim is to understand the cause of stroke in every single patient. Brain microinfarcts and macroinfarcts cause a major healthcare burden in Western societies both in terms of morbidity and costs. Cardiovascular thromboemboli from the heart, aorta and neck arteries are considered as the main cause. Still, the vast majority of brain infarcts are unexplained. In contrast to the thromboembolic explanation for brain infarcts, heart infarcts are known to be caused by local atherosclerotic plaque of the coronary arteries and impaired perfusion. This has led to successful preventive and therapeutic strategies against myocardial infarction. For brain infarcts, a blind eye is turned to local atherosclerotic plaque in the intracranial vasculature (Pipes) and impaired Perfusion as possible causes of macro and microinfarcts (Parenchyma). For the ‘3Ps’ (Pipes, Perfusion, Parenchyma) I have created new research fields based on innovative noninvasive arterial spin labeling perfusion MRI, perfusion reserve, perfusion territory and vessel wall MRI methods. In this project, I will go an important step beyond the state of the art by investigating the total intracranial burden of disease of these ‘3Ps’ and systematic evaluations in patients. Pipes: novel methods to visualise and characterise intracranial plaque including inflammatory plaque enhancement, intraplaque haemorrhage and calcification detection. Perfusion: novel methods to investigate hemodynamic impairment in areas with critically low perfusion with noninvasive arterial spin labeling MRI methods and perfusion reserve methods specific for each intracranial perfusion territory. Parenchyma: novel methods to detect microinfarcts. Technical innovations (Pipes, Perfusion) will be applied in synergy to explain micro and macroinfarcts (Parenchyma). Patient specific biomarkers will, similar to the heart, pave the way for designing preventive and therapeutic strategies aimed at reducing the burden of neurodegenerative diseases.


year authors and title journal last update
List of publications.
2019 M.H.T. Zwartbol, M.I. Geerlings, R. Ghaznawi, J. Hendrikse, A.G. van der Kolk
Intracranial Atherosclerotic Burden on 7T MRI Is Associated with Markers of Extracranial Atherosclerosis: The SMART-MR Study
published pages: , ISSN: 0195-6108, DOI: 10.3174/ajnr.a6308
American Journal of Neuroradiology 2020-04-15
2020 Lisa A. van der Kleij, Jill B. De Vis, Jeroen de Bresser, Jeroen Hendrikse, Jeroen C. W. Siero
Arterial CO2 pressure changes during hypercapnia are associated with changes in brain parenchymal volume
published pages: , ISSN: 2509-9280, DOI: 10.1186/s41747-020-0144-z
European Radiology Experimental 4/1 2020-04-15
2020 Arjen Lindenholz, Anja G. van der Kolk, Irene C. van der Schaaf, H. Bart van der Worp, Anita A. Harteveld, Nikki Dieleman, Michiel L. Bots, Jeroen Hendrikse
Intracranial Atherosclerosis Assessed with 7-T MRI: Evaluation of Patients with Ischemic Stroke or Transient Ischemic Attack
published pages: 162-170, ISSN: 0033-8419, DOI: 10.1148/radiol.2020190643
Radiology 295/1 2020-04-15
2016 Nikki Dieleman, Wenjie Yang, Jill M. Abrigo, Winnie Chiu Wing Chu, Anja G. van der Kolk, Jeroen C.W. Siero, Ka Sing Wong, Jeroen Hendrikse, Xiang Yan Chen
Magnetic Resonance Imaging of Plaque Morphology, Burden, and Distribution in Patients With Symptomatic Middle Cerebral Artery Stenosis
published pages: 1797-1802, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.116.013007
Stroke 47/7 2019-05-27
2016 Nikki Dieleman, Wenjie Yang, Anja G. van der Kolk, Jill Abrigo, Ka Lok Lee, Winnie Chiu Wing Chu, Jaco J. M. Zwanenburg, Jeroen C. W. Siero, Ka Sing Wong, Jeroen Hendrikse, Fiona Xiang Yan Chen
Qualitative Evaluation of a High-Resolution 3D Multi-Sequence Intracranial Vessel Wall Protocol at 3 Tesla MRI
published pages: e0160781, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0160781
PLOS ONE 11/8 2019-05-27
2016 Laurens JL De Cocker, Arjen Lindenholz, Jaco JM Zwanenburg, Anja G van der Kolk, Maarten Zwartbol, Peter R Luijten, Jeroen Hendrikse
Clinical vascular imaging in the brain at 7T
published pages: , ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2016.11.044
NeuroImage 2019-05-27
2016 Thomas Alderliesten, Jill B. De Vis, Petra M.A. Lemmers, Frank van Bel, Manon J.N.L. Benders, Jeroen Hendrikse, Esben T. Petersen
T 2 -prepared velocity selective labelling: A novel idea for full-brain mapping of oxygen saturation
published pages: 65-73, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2016.06.012
NeuroImage 139 2019-04-25
2017 Anita A. Harteveld, Anja G. van der Kolk, H. Bart van der Worp, Nikki Dieleman, Jaco J.M. Zwanenburg, Peter R. Luijten, Jeroen Hendrikse
Detecting Intracranial Vessel Wall Lesions With 7T-Magnetic Resonance Imaging
published pages: 2601-2604, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.117.017868
Stroke 48/9 2019-05-27
2017 Rashid Ghaznawi, Jeroen de Bresser, Yolanda van der Graaf, Maarten HT Zwartbol, Theo D Witkamp, Mirjam I Geerlings, Jeroen Hendrikse
Detection and characterization of small infarcts in the caudate nucleus on 7 Tesla MRI: The SMART-MR study
published pages: 0271678X1770597, ISSN: 0271-678X, DOI: 10.1177/0271678X17705974
Journal of Cerebral Blood Flow & Metabolism 2019-05-27
2015 Laurens J.L. De Cocker, Raoul P. Kloppenborg, Yolanda van der Graaf, Peter R. Luijten, Jeroen Hendrikse, Mirjam I. Geerlings
Cerebellar Cortical Infarct Cavities
published pages: STROKEAHA.115.01, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.115.010093
Stroke 2019-05-27
2016 A. A. Harteveld, N. P. Denswil, J. C. W. Siero, J. J. M. Zwanenburg, A. Vink, B. Pouran, W. G. M. Spliet, D. W. J. Klomp, P. R. Luijten, M. J. Daemen, J. Hendrikse, A. G. van der Kolk
Quantitative Intracranial Atherosclerotic Plaque Characterization at 7T MRI: An Ex Vivo Study with Histologic Validation
published pages: 802-810, ISSN: 0195-6108, DOI: 10.3174/ajnr.A4628
American Journal of Neuroradiology 37/5 2019-04-25
2015 A. G. van der Kolk, J. J. M. Zwanenburg, N. P. Denswil, A. Vink, W. G. M. Spliet, M. J. A. P. Daemen, F. Visser, D. W. J. Klomp, P. R. Luijten, J. Hendrikse
Imaging the Intracranial Atherosclerotic Vessel Wall Using 7T MRI: Initial Comparison with Histopathology
published pages: 694-701, ISSN: 0195-6108, DOI: 10.3174/ajnr.A4178
American Journal of Neuroradiology 36/4 2019-04-25
2016 Anita A. Harteveld, Anja G. van der Kolk, H. Bart van der Worp, Nikki Dieleman, Jeroen C. W. Siero, Hugo J. Kuijf, Catharina J. M. Frijns, Peter R. Luijten, Jaco J. M. Zwanenburg, Jeroen Hendrikse
High-resolution intracranial vessel wall MRI in an elderly asymptomatic population: comparison of 3T and 7T
published pages: , ISSN: 0938-7994, DOI: 10.1007/s00330-016-4483-3
European Radiology 2019-05-27
2016 Diederik P.J. Smeeing, Jeroen Hendrikse, Esben T. Petersen, Manus J. Donahue, Jill B. de Vis
Arterial Spin Labeling and Blood Oxygen Level-Dependent MRI Cerebrovascular Reactivity in Cerebrovascular Disease: A Systematic Review and Meta-Analysis
published pages: 288-307, ISSN: 1015-9770, DOI: 10.1159/000446081
Cerebrovascular Diseases 42/3-4 2019-05-27
2017 Manus J Donahue, Eric Achten, Petrice M Cogswell, Frank-Erik De Leeuw, Colin P Derdeyn, Rick M Dijkhuizen, Audrey P Fan, Rashid Ghaznawi, Jeremy J Heit, M Arfan Ikram, Peter Jezzard, Lori C Jordan, Eric Jouvent, Linda Knutsson, Richard Leigh, David S Liebeskind, Weili Lin, Thomas W Okell, Adnan I Qureshi, Charlotte J Stagg, Matthias JP van Osch, Peter CM van Zijl, Jennifer M Watchmaker, Max Wintermark, Ona Wu, Greg Zaharchuk, Jinyuan Zhou, Jeroen Hendrikse
Consensus statement on current and emerging methods for the diagnosis and evaluation of cerebrovascular disease
published pages: 0271678X1772183, ISSN: 0271-678X, DOI: 10.1177/0271678X17721830
Journal of Cerebral Blood Flow & Metabolism 2019-05-27
2016 Nolan S Hartkamp, J Hendrikse, Laurens J L De Cocker, Gert Jan de Borst, L Jaap Kappelle, Reinoud P H Bokkers
Misinterpretation of ischaemic infarct location in relationship to the cerebrovascular territories
published pages: 1084-1090, ISSN: 0022-3050, DOI: 10.1136/jnnp-2015-312906
Journal of Neurology, Neurosurgery & Psychiatry 87/10 2019-05-27
2017 Laurens J.L. De Cocker, Karl-Olof Lövblad, Jeroen Hendrikse
MRI of Cerebellar Infarction
published pages: 137-146, ISSN: 0014-3022, DOI: 10.1159/000455229
European Neurology 77/3-4 2019-05-27

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