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HEARTOFSTROKE SIGNED

The heart of stroke: Pipes, Perfusion, Parenchyma

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

HEARTOFSTROKE project word cloud

Explore the words cloud of the HEARTOFSTROKE project. It provides you a very rough idea of what is the project "HEARTOFSTROKE" about.

arteries vessel majority heart haemorrhage macroinfarcts mri aorta morbidity inflammatory myocardial understand local microinfarcts intracranial systematic created parenchyma innovative stroke patient eye led plaque impaired macro neurodegenerative designing evaluations innovations atherosclerotic impairment single infarcts thromboemboli caused western vast preventive diseases labeling turned brain neck contrast intraplaque hemodynamic noninvasive 3ps causes burden total pipes explanation successful reducing healthcare strategies spin synergy arterial reserve detection cardiovascular societies micro wall coronary disease territory infarction enhancement blind vasculature critically calcification patients therapeutic perfusion characterise thromboembolic detect unexplained biomarkers visualise pave my

Project "HEARTOFSTROKE" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	1˙499˙450 €
EC max contribution	1˙499˙450 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-STG
Funding Scheme	ERC-STG
Starting year	2015
Duration (year-month-day)	from 2015-03-01 to 2020-02-29

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAIR MEDISCH CENTRUM UTRECHT UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	coordinator	1˙499˙450.00

Map

Project objective

My aim is to understand the cause of stroke in every single patient. Brain microinfarcts and macroinfarcts cause a major healthcare burden in Western societies both in terms of morbidity and costs. Cardiovascular thromboemboli from the heart, aorta and neck arteries are considered as the main cause. Still, the vast majority of brain infarcts are unexplained. In contrast to the thromboembolic explanation for brain infarcts, heart infarcts are known to be caused by local atherosclerotic plaque of the coronary arteries and impaired perfusion. This has led to successful preventive and therapeutic strategies against myocardial infarction. For brain infarcts, a blind eye is turned to local atherosclerotic plaque in the intracranial vasculature (Pipes) and impaired Perfusion as possible causes of macro and microinfarcts (Parenchyma). For the ‘3Ps’ (Pipes, Perfusion, Parenchyma) I have created new research fields based on innovative noninvasive arterial spin labeling perfusion MRI, perfusion reserve, perfusion territory and vessel wall MRI methods. In this project, I will go an important step beyond the state of the art by investigating the total intracranial burden of disease of these ‘3Ps’ and systematic evaluations in patients. Pipes: novel methods to visualise and characterise intracranial plaque including inflammatory plaque enhancement, intraplaque haemorrhage and calcification detection. Perfusion: novel methods to investigate hemodynamic impairment in areas with critically low perfusion with noninvasive arterial spin labeling MRI methods and perfusion reserve methods specific for each intracranial perfusion territory. Parenchyma: novel methods to detect microinfarcts. Technical innovations (Pipes, Perfusion) will be applied in synergy to explain micro and macroinfarcts (Parenchyma). Patient specific biomarkers will, similar to the heart, pave the way for designing preventive and therapeutic strategies aimed at reducing the burden of neurodegenerative diseases.

Publications

List of publications.
year	authors and title	journal	last update
2019	M.H.T. Zwartbol, M.I. Geerlings, R. Ghaznawi, J. Hendrikse, A.G. van der Kolk Intracranial Atherosclerotic Burden on 7T MRI Is Associated with Markers of Extracranial Atherosclerosis: The SMART-MR Study published pages: , ISSN: 0195-6108, DOI: 10.3174/ajnr.a6308	American Journal of Neuroradiology	2020-04-15
2020	Lisa A. van der Kleij, Jill B. De Vis, Jeroen de Bresser, Jeroen Hendrikse, Jeroen C. W. Siero Arterial CO2 pressure changes during hypercapnia are associated with changes in brain parenchymal volume published pages: , ISSN: 2509-9280, DOI: 10.1186/s41747-020-0144-z	European Radiology Experimental 4/1	2020-04-15
2020	Arjen Lindenholz, Anja G. van der Kolk, Irene C. van der Schaaf, H. Bart van der Worp, Anita A. Harteveld, Nikki Dieleman, Michiel L. Bots, Jeroen Hendrikse Intracranial Atherosclerosis Assessed with 7-T MRI: Evaluation of Patients with Ischemic Stroke or Transient Ischemic Attack published pages: 162-170, ISSN: 0033-8419, DOI: 10.1148/radiol.2020190643	Radiology 295/1	2020-04-15
2016	Nikki Dieleman, Wenjie Yang, Jill M. Abrigo, Winnie Chiu Wing Chu, Anja G. van der Kolk, Jeroen C.W. Siero, Ka Sing Wong, Jeroen Hendrikse, Xiang Yan Chen Magnetic Resonance Imaging of Plaque Morphology, Burden, and Distribution in Patients With Symptomatic Middle Cerebral Artery Stenosis published pages: 1797-1802, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.116.013007	Stroke 47/7	2019-05-27
2016	Nikki Dieleman, Wenjie Yang, Anja G. van der Kolk, Jill Abrigo, Ka Lok Lee, Winnie Chiu Wing Chu, Jaco J. M. Zwanenburg, Jeroen C. W. Siero, Ka Sing Wong, Jeroen Hendrikse, Fiona Xiang Yan Chen Qualitative Evaluation of a High-Resolution 3D Multi-Sequence Intracranial Vessel Wall Protocol at 3 Tesla MRI published pages: e0160781, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0160781	PLOS ONE 11/8	2019-05-27
2016	Laurens JL De Cocker, Arjen Lindenholz, Jaco JM Zwanenburg, Anja G van der Kolk, Maarten Zwartbol, Peter R Luijten, Jeroen Hendrikse Clinical vascular imaging in the brain at 7T published pages: , ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2016.11.044	NeuroImage	2019-05-27
2016	Thomas Alderliesten, Jill B. De Vis, Petra M.A. Lemmers, Frank van Bel, Manon J.N.L. Benders, Jeroen Hendrikse, Esben T. Petersen T 2 -prepared velocity selective labelling: A novel idea for full-brain mapping of oxygen saturation published pages: 65-73, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2016.06.012	NeuroImage 139	2019-04-25
2017	Anita A. Harteveld, Anja G. van der Kolk, H. Bart van der Worp, Nikki Dieleman, Jaco J.M. Zwanenburg, Peter R. Luijten, Jeroen Hendrikse Detecting Intracranial Vessel Wall Lesions With 7T-Magnetic Resonance Imaging published pages: 2601-2604, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.117.017868	Stroke 48/9	2019-05-27
2017	Rashid Ghaznawi, Jeroen de Bresser, Yolanda van der Graaf, Maarten HT Zwartbol, Theo D Witkamp, Mirjam I Geerlings, Jeroen Hendrikse Detection and characterization of small infarcts in the caudate nucleus on 7 Tesla MRI: The SMART-MR study published pages: 0271678X1770597, ISSN: 0271-678X, DOI: 10.1177/0271678X17705974	Journal of Cerebral Blood Flow & Metabolism	2019-05-27
2015	Laurens J.L. De Cocker, Raoul P. Kloppenborg, Yolanda van der Graaf, Peter R. Luijten, Jeroen Hendrikse, Mirjam I. Geerlings Cerebellar Cortical Infarct Cavities published pages: STROKEAHA.115.01, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.115.010093	Stroke	2019-05-27
2016	A. A. Harteveld, N. P. Denswil, J. C. W. Siero, J. J. M. Zwanenburg, A. Vink, B. Pouran, W. G. M. Spliet, D. W. J. Klomp, P. R. Luijten, M. J. Daemen, J. Hendrikse, A. G. van der Kolk Quantitative Intracranial Atherosclerotic Plaque Characterization at 7T MRI: An Ex Vivo Study with Histologic Validation published pages: 802-810, ISSN: 0195-6108, DOI: 10.3174/ajnr.A4628	American Journal of Neuroradiology 37/5	2019-04-25
2015	A. G. van der Kolk, J. J. M. Zwanenburg, N. P. Denswil, A. Vink, W. G. M. Spliet, M. J. A. P. Daemen, F. Visser, D. W. J. Klomp, P. R. Luijten, J. Hendrikse Imaging the Intracranial Atherosclerotic Vessel Wall Using 7T MRI: Initial Comparison with Histopathology published pages: 694-701, ISSN: 0195-6108, DOI: 10.3174/ajnr.A4178	American Journal of Neuroradiology 36/4	2019-04-25
2016	Anita A. Harteveld, Anja G. van der Kolk, H. Bart van der Worp, Nikki Dieleman, Jeroen C. W. Siero, Hugo J. Kuijf, Catharina J. M. Frijns, Peter R. Luijten, Jaco J. M. Zwanenburg, Jeroen Hendrikse High-resolution intracranial vessel wall MRI in an elderly asymptomatic population: comparison of 3T and 7T published pages: , ISSN: 0938-7994, DOI: 10.1007/s00330-016-4483-3	European Radiology	2019-05-27
2016	Diederik P.J. Smeeing, Jeroen Hendrikse, Esben T. Petersen, Manus J. Donahue, Jill B. de Vis Arterial Spin Labeling and Blood Oxygen Level-Dependent MRI Cerebrovascular Reactivity in Cerebrovascular Disease: A Systematic Review and Meta-Analysis published pages: 288-307, ISSN: 1015-9770, DOI: 10.1159/000446081	Cerebrovascular Diseases 42/3-4	2019-05-27
2017	Manus J Donahue, Eric Achten, Petrice M Cogswell, Frank-Erik De Leeuw, Colin P Derdeyn, Rick M Dijkhuizen, Audrey P Fan, Rashid Ghaznawi, Jeremy J Heit, M Arfan Ikram, Peter Jezzard, Lori C Jordan, Eric Jouvent, Linda Knutsson, Richard Leigh, David S Liebeskind, Weili Lin, Thomas W Okell, Adnan I Qureshi, Charlotte J Stagg, Matthias JP van Osch, Peter CM van Zijl, Jennifer M Watchmaker, Max Wintermark, Ona Wu, Greg Zaharchuk, Jinyuan Zhou, Jeroen Hendrikse Consensus statement on current and emerging methods for the diagnosis and evaluation of cerebrovascular disease published pages: 0271678X1772183, ISSN: 0271-678X, DOI: 10.1177/0271678X17721830	Journal of Cerebral Blood Flow & Metabolism	2019-05-27
2016	Nolan S Hartkamp, J Hendrikse, Laurens J L De Cocker, Gert Jan de Borst, L Jaap Kappelle, Reinoud P H Bokkers Misinterpretation of ischaemic infarct location in relationship to the cerebrovascular territories published pages: 1084-1090, ISSN: 0022-3050, DOI: 10.1136/jnnp-2015-312906	Journal of Neurology, Neurosurgery & Psychiatry 87/10	2019-05-27
2017	Laurens J.L. De Cocker, Karl-Olof LÃ¶vblad, Jeroen Hendrikse MRI of Cerebellar Infarction published pages: 137-146, ISSN: 0014-3022, DOI: 10.1159/000455229	European Neurology 77/3-4	2019-05-27

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