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Building up a brain: understanding how neural stem cell fate and regulation controls nervous tissue architecture

Total Cost €


EC-Contrib. €






 BRAINSTRUCT project word cloud

Explore the words cloud of the BRAINSTRUCT project. It provides you a very rough idea of what is the project "BRAINSTRUCT" about.

postnatal    intrinsic    simultaneously    experimentally    glial    functional    mechanisms    heterogeneity    underpins    disorders    explored    cell    intact    regulated    precursors    strategies    link    situ    perturb    single    volume    cortex    extraordinary    functions    basis    perturbations    mature    potentialities    niche    decipher    pathological    lineage    circuit    transgenic    organization    poorly    function    combination    neural    occurring    neurodevelopmental    clonal    connectivity    stem    assembly    clones    cognitive    reveal    describe    individual    track    progenitor    distribute    assay    structure    multiple    appropriate    tissue    architecture    experiments    cells    equivalence    regulating    circuitry    extrinsic    influence    aetiology    outcome    environment    embryonic    mouse    likewise    neuronal    throughput    output    quantitative    multidisciplinary    understand    signals    deciphering    interactions    resolution    developmental    imaging    intercellular    debated    interconnect    brain    neurogenic    normal    local   

Project "BRAINSTRUCT" data sheet

The following table provides information about the project.


There are not information about this coordinator. Please contact Fabio for more information, thanks.

 Coordinator Country France [FR]
 Total cost 1˙929˙713 €
 EC max contribution 1˙929˙713 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2020-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SORBONNE UNIVERSITE FR (PARIS) coordinator 1˙929˙713.00


 Project objective

The brain is an extraordinary complex assembly of neuronal and glial cells that underpins cognitive functions. How adequate numbers of these cells are generated by neural stem cells in embryonic and early postnatal development and how they distribute and interconnect within brain tissue is still debated. In particular, the potentialities of individual neural stem cells, their potential heterogeneity and the mechanisms regulating their function are still poorly characterized in situ; likewise, the clonal architecture of mature brain tissue and its influence on neural circuitry are only partially explored. Deciphering these aspects is essential to link neural circuit development, structure and function, and to understand the aetiology of neurodevelopmental disorders.

We have recently established transgenic strategies to simultaneously track the lineage of multiple individual neural stem cells in the intact developing brain and experimentally perturb their development. We will use these approaches in combination with recent large-volume imaging methods for high-throughput analysis of individual neural and glial clones in the mouse cortex. This will allow us to assay neural progenitor potentialities and equivalence, characterize developmental changes occurring in the neurogenic niche, describe the clonal organization of the mature cortex and study its link with neural connectivity. To decipher intrinsic and extrinsic mechanisms regulating neural progenitor activity and understand how they produce appropriate numbers of cells, we will assay the outcome of functional perturbations targeting key steps of neural development, introduced in precursors or in their local environment. These experiments will reveal how neural stem cell output might be regulated by cell interactions and intercellular signals. This multidisciplinary project will set the basis for quantitative analysis of brain development with single-cell resolution in normal and pathological conditions.


year authors and title journal last update
List of publications.
2019 Takuma Kumamoto, Franck Maurinot, Raphaëlle Barry, Célia Vaslin, Sandrine Vandormael-Pournin, Mickaël Le, Marion Lerat, Michel Cohen-Tannoudji, Alexandra Rebsam, Karine Loulier, Stéphane Nédelec, Samuel Tozer, Jean Livet
Direct readout of neural stem cell transgenesis with an integration-coupled gene expression switch
published pages: , ISSN: , DOI: 10.1101/834424
bioRXiv 2020-02-19
2019 Gonzalo Ortiz-Álvarez, Marie Daclin, Asm Shihavuddin, Pauline Lansade, Aurélien Fortoul, Marion Faucourt, Solène Clavreul, Maria-Eleni Lalioti, Stavros Taraviras, Simon Hippenmeyer, Jean Livet, Alice Meunier, Auguste Genovesio, Nathalie Spassky
Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members
published pages: 159-172.e7, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2019.01.051
Neuron 102/1 2020-02-19
2019 Solène Clavreul, Lamiae Abdeladim, Edwin Hernández-Garzón, Dragos Niculescu, Jason Durand, Sio-Hoï Ieng, Raphaëlle Barry, Gilles Bonvento, Emmanuel Beaurepaire, Jean Livet, Karine Loulier
Cortical astrocytes develop in a plastic manner at both clonal and cellular levels
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-12791-5
Nature Communications 10/1 2020-02-19
2019 Lamiae Abdeladim, Katherine S. Matho, Solène Clavreul, Pierre Mahou, Jean-Marc Sintes, Xavier Solinas, Ignacio Arganda-Carreras, Stephen G. Turney, Jeff W. Lichtman, Anatole Chessel, Alexis-Pierre Bemelmans, Karine Loulier, Willy Supatto, Jean Livet, Emmanuel Beaurepaire
Multicolor multiscale brain imaging with chromatic multiphoton serial microscopy
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09552-9
Nature Communications 10/1 2020-02-19
2018 Khmaies Guesmi, Lamiae Abdeladim, Samuel Tozer, Pierre Mahou, Takuma Kumamoto, Karolis Jurkus, Philippe Rigaud, Karine Loulier, Nicolas Dray, Patrick Georges, Marc Hanna, Jean Livet, Willy Supatto, Emmanuel Beaurepaire, Frédéric Druon
Dual-color deep-tissue three-photon microscopy with a multiband infrared laser
published pages: , ISSN: 2047-7538, DOI: 10.1038/s41377-018-0012-2
Light: Science & Applications 7/1 2019-06-07
2017 P Cadroas, L Abdeladim, L Kotov, M Likhachev, D Lipatov, D Gaponov, A Hideur, M Tang, J Livet, W Supatto, E Beaurepaire, S Février
All-fiber femtosecond laser providing 9 nJ, 50 MHz pulses at 1650 nm for three-photon microscopy
published pages: 65506, ISSN: 2040-8978, DOI: 10.1088/2040-8986/aa6f72
Journal of Optics 19/6 2019-06-07
2016 Roy E, Neufeld Z, Cerone L, Wong HY, Hodgson S, Livet J, Khosrotehrani K
Bimodal behaviour of interfollicular epidermal progenitors regulated by hair follicle position and cycling.
published pages: 15;35(24):2658-2, ISSN: 0261-4189, DOI: 10.15252/embj.201693806
EMBO J 2019-06-07

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