Explore the words cloud of the BRAINSTRUCT project. It provides you a very rough idea of what is the project "BRAINSTRUCT" about.
The following table provides information about the project.
UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6
There are not information about this coordinator. Please contact Fabio for more information, thanks.
|Coordinator Country||France [FR]|
|Total cost||1˙929˙713 €|
|EC max contribution||1˙929˙713 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-07-01 to 2020-06-30|
Take a look of project's partnership.
|1||SORBONNE UNIVERSITE||FR (PARIS)||coordinator||1˙929˙713.00|
|2||UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6||FR (PARIS)||coordinator||0.00|
The brain is an extraordinary complex assembly of neuronal and glial cells that underpins cognitive functions. How adequate numbers of these cells are generated by neural stem cells in embryonic and early postnatal development and how they distribute and interconnect within brain tissue is still debated. In particular, the potentialities of individual neural stem cells, their potential heterogeneity and the mechanisms regulating their function are still poorly characterized in situ; likewise, the clonal architecture of mature brain tissue and its influence on neural circuitry are only partially explored. Deciphering these aspects is essential to link neural circuit development, structure and function, and to understand the aetiology of neurodevelopmental disorders.
We have recently established transgenic strategies to simultaneously track the lineage of multiple individual neural stem cells in the intact developing brain and experimentally perturb their development. We will use these approaches in combination with recent large-volume imaging methods for high-throughput analysis of individual neural and glial clones in the mouse cortex. This will allow us to assay neural progenitor potentialities and equivalence, characterize developmental changes occurring in the neurogenic niche, describe the clonal organization of the mature cortex and study its link with neural connectivity. To decipher intrinsic and extrinsic mechanisms regulating neural progenitor activity and understand how they produce appropriate numbers of cells, we will assay the outcome of functional perturbations targeting key steps of neural development, introduced in precursors or in their local environment. These experiments will reveal how neural stem cell output might be regulated by cell interactions and intercellular signals. This multidisciplinary project will set the basis for quantitative analysis of brain development with single-cell resolution in normal and pathological conditions.
|year||authors and title||journal||last update|
Takuma Kumamoto, Franck Maurinot, RaphaÃ«lle Barry, CÃ©lia Vaslin, Sandrine Vandormael-Pournin, MickaÃ«l Le, Marion Lerat, Michel Cohen-Tannoudji, Alexandra Rebsam, Karine Loulier, StÃ©phane NÃ©delec, Samuel Tozer, Jean Livet
Direct readout of neural stem cell transgenesis with an integration-coupled gene expression switch
published pages: , ISSN: , DOI: 10.1101/834424
Gonzalo Ortiz-Ãlvarez, Marie Daclin, Asm Shihavuddin, Pauline Lansade, AurÃ©lien Fortoul, Marion Faucourt, SolÃ¨ne Clavreul, Maria-Eleni Lalioti, Stavros Taraviras, Simon Hippenmeyer, Jean Livet, Alice Meunier, Auguste Genovesio, Nathalie Spassky
Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members
published pages: 159-172.e7, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2019.01.051
SolÃ¨ne Clavreul, Lamiae Abdeladim, Edwin HernÃ¡ndez-GarzÃ³n, Dragos Niculescu, Jason Durand, Sio-HoÃ¯ Ieng, RaphaÃ«lle Barry, Gilles Bonvento, Emmanuel Beaurepaire, Jean Livet, Karine Loulier
Cortical astrocytes develop in a plastic manner at both clonal and cellular levels
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-12791-5
|Nature Communications 10/1||2020-02-19|
Lamiae Abdeladim, Katherine S. Matho, SolÃ¨ne Clavreul, Pierre Mahou, Jean-Marc Sintes, Xavier Solinas, Ignacio Arganda-Carreras, Stephen G. Turney, Jeff W. Lichtman, Anatole Chessel, Alexis-Pierre Bemelmans, Karine Loulier, Willy Supatto, Jean Livet, Emmanuel Beaurepaire
Multicolor multiscale brain imaging with chromatic multiphoton serial microscopy
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-09552-9
|Nature Communications 10/1||2020-02-19|
Khmaies Guesmi, Lamiae Abdeladim, Samuel Tozer, Pierre Mahou, Takuma Kumamoto, Karolis Jurkus, Philippe Rigaud, Karine Loulier, Nicolas Dray, Patrick Georges, Marc Hanna, Jean Livet, Willy Supatto, Emmanuel Beaurepaire, FrÃ©dÃ©ric Druon
Dual-color deep-tissue three-photon microscopy with a multiband infrared laser
published pages: , ISSN: 2047-7538, DOI: 10.1038/s41377-018-0012-2
|Light: Science & Applications 7/1||2019-06-07|
P Cadroas, L Abdeladim, L Kotov, M Likhachev, D Lipatov, D Gaponov, A Hideur, M Tang, J Livet, W Supatto, E Beaurepaire, S FÃ©vrier
All-fiber femtosecond laser providing 9 nJ, 50 MHz pulses at 1650 nm for three-photon microscopy
published pages: 65506, ISSN: 2040-8978, DOI: 10.1088/2040-8986/aa6f72
|Journal of Optics 19/6||2019-06-07|
Roy E, Neufeld Z, Cerone L, Wong HY, Hodgson S, Livet J, Khosrotehrani K
Bimodal behaviour of interfollicular epidermal progenitors regulated by hair follicle position and cycling.
published pages: 15;35(24):2658-2, ISSN: 0261-4189, DOI: 10.15252/embj.201693806
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