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EyeRegen SIGNED

Engineering a scaffold based therapy for corneal regeneration

Total Cost €

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EC-Contrib. €

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Partnership

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 EyeRegen project word cloud

Explore the words cloud of the EyeRegen project. It provides you a very rough idea of what is the project "EyeRegen" about.

fundamentally    differ    physical    prior    disease    recruit    mimicking    vision    periods    chemical    shortage    ing    scaffolds    biochemical    alternative    inducing    donor    suitable    biomaterial    artificial    post    examine    blindness    release    corneal    3d    animal    material    architectures    restore    manufacturing    necessitated    attract    people    economic    bio    vitro    cornea    incorporated    donated    scaffold    treatments    attracting    live    examined    expense    nanofiber    cues    instead    attempt    transplantation    nanometric    millions    limited    performing    cells    tests    remodelling    epithelial    once    tissue    social    injury    combination    deliberate    model    electrospinning    engineering    stromal    worldwide    undertaken    environment    implantation    printing    fabricate    culture    regenerate    considerable    mechanisms    optimal    lives    regeneration    bioreactor    vivo    matrix    techniques    transplants    patient    ocular    lengthy    mechanical    corneas    incorporate    endothelial    determined    grow    burns   

Project "EyeRegen" data sheet

The following table provides information about the project.

Coordinator
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN 

Organization address
address: College Green
city: DUBLIN
postcode: 2
website: www.tcd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 1˙498˙734 €
 EC max contribution 1˙498˙734 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN IE (DUBLIN) coordinator 1˙498˙734.00

Map

 Project objective

Corneal blindness resulting from disease, physical injury or chemical burns affects millions worldwide and has a considerable economic and social impact on the lives of people across Europe. In many cases corneal transplants can restore vision however the shortage of donor corneas suitable for transplantation has necessitated the development of alternative treatments. The aim of this project is to develop a new approach to corneal tissue regeneration. Previous approaches at engineering corneal tissue have required access to donor cells and lengthy culture periods in an attempt to grow tissue in vitro prior to implantation with only limited success and at great expense. Our approach will differ fundamentally from these in that we will design artificial corneal scaffolds that do not require donated cells or in vitro culture but instead will recruit the patient’s own cells to regenerate the cornea post-implantation. These biomaterial scaffolds will incorporate specific chemical and physical cues with the deliberate aim of attracting cells and inducing tissue formation. Studies will be undertaken to examine how different chemical, biochemical, physical and mechanical cues can be used to control the behaviour of corneal epithelial, stromal and endothelial cells. Once the optimal combination of these cues has been determined, this information will be incorporated into the design of the scaffold. Recent advances in manufacturing and material processing technology will enable us to develop scaffolds with organized nanometric architectures and that incorporate controlled growth factor release mechanisms. Techniques such as 3D bio-printing and nanofiber electrospinning will be used to fabricate scaffolds. The ability of the scaffold to attract cells and promote matrix remodelling will be examined by developing an in vitro bioreactor system capable of mimicking the ocular environment and by performing in vivo tests using a live animal model.

 Publications

year authors and title journal last update
List of publications.
2019 Sophia Masterton, Mark Ahearne
The Effect of Calcium and Glucose Concentration on Corneal Epithelial Cell Lines Differentiation, Proliferation, and Focal Adhesion Expression
published pages: 74-83, ISSN: 2164-7860, DOI: 10.1089/biores.2018.0036
BioResearch Open Access 8/1 2020-01-29
2019 Sophia Masterton, Mark Ahearne
Influence of polydimethylsiloxane substrate stiffness on corneal epithelial cells
published pages: 191796, ISSN: 2054-5703, DOI: 10.1098/rsos.191796
Royal Society Open Science 6/12 2020-01-30
2020 Julia Fernández-Pérez, Karl E. Kador, Amy P. Lynch, Mark Ahearne
Characterization of extracellular matrix modified poly(ε-caprolactone) electrospun scaffolds with differing fiber orientations for corneal stroma regeneration
published pages: 110415, ISSN: 0928-4931, DOI: 10.1016/j.msec.2019.110415
Materials Science and Engineering: C 108 2019-12-16
2019 Promita Bhattacharjee, Julia Fernández-Pérez, Mark Ahearne
Potential for combined delivery of riboflavin and all-trans retinoic acid, from silk fibroin for corneal bioengineering
published pages: 110093, ISSN: 0928-4931, DOI: 10.1016/j.msec.2019.110093
Materials Science and Engineering: C 105 2019-12-16
2019 Julia Fernández-Pérez, Mark Ahearne
The impact of decellularization methods on extracellular matrix derived hydrogels
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-49575-2
Scientific Reports 9/1 2019-12-16
2018 Julia Fernández-Pérez, Mark Ahearne
Influence of Biochemical Cues in Human Corneal Stromal Cell Phenotype
published pages: 1-12, ISSN: 0271-3683, DOI: 10.1080/02713683.2018.1536216
Current Eye Research 44:2, 135-146 2019-04-18
2018 Sophia Masterton, Mark Ahearne
Mechanobiology of the corneal epithelium
published pages: 122-129, ISSN: 0014-4835, DOI: 10.1016/j.exer.2018.08.001
Experimental Eye Research 177 2019-04-18

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The information about "EYEREGEN" are provided by the European Opendata Portal: CORDIS opendata.

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