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PentaBrain SIGNED

Structural studies of mammalian Cys-loop receptors

Total Cost €


EC-Contrib. €






 PentaBrain project word cloud

Explore the words cloud of the PentaBrain project. It provides you a very rough idea of what is the project "PentaBrain" about.

record    molecules    bacterial    neurotransmission    resolution    molecular    anaesthetics    active    preliminary    missing    mechanism    invertebrate    intrinsic    channel    function    crystallization    modulators    signal    transitions    operation    drugs    decipher    legion    brain    proposes    acutely    nicotine    compounds    antibody    receptors    understand    conformational    benzodiazepines    environment    emetics    solved    first    psycho    body    receptor    advantage    extracellular    mammalian    france    grenoble    cnrs    chaperones    serotonin    opening    starting    undergo    pharmacology    limited    transducers    homologues    acetylcholine    fast    binding    site    gating    mediate    transient    structural    time    neurotransmitter    loop    anti    structures    gaba    activated    movie    mouse    cys    biomedical    place    membrane    physiological    ion    family    atomic    allosteric    therapeutic    obtain    transition    biology    cristallo    glycine    plasma    solid   

Project "PentaBrain" data sheet

The following table provides information about the project.


Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2020-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

In the brain, Cys-loop receptors mediate fast neurotransmission. They function as allosteric signal transducers across the plasma membrane: upon binding of one or more neurotransmitter molecules to an extracellular site, the receptors undergo complex conformational transitions that result in transient opening of an intrinsic ion channel. The Cys-loop family comprises receptors activated by serotonin, acetylcholine, glycine and GABA. Mammalian receptors are also the targets of a legion of psycho-active and therapeutic compounds (including nicotine, benzodiazepines, anti-emetics, general anaesthetics). Our structural knowledge is currently limited to invertebrate homologues. Atomic structures mammalian receptors are therefore acutely missing in order to understand their physiological role in molecular terms, and to be able to develop new drugs targeting them.

The project proposes to decipher the operation mechanism, the pharmacology and conformational transitions of mammalian Cys-loop receptors. Starting with a solid body of preliminary results, we will obtain new high-resolution structures, taking advantage of antibody-based crystallization chaperones. We will try and record for the first time a ‘molecular movie’ of the gating conformational transition in cristallo. On the way, we will also investigate the potential of antibody-based modulators of Cys-loop receptors for biomedical applications.

The applicant has solved in the past the structures of a bacterial Cys-loop receptor and of the mouse serotonin receptor. The proposed research will take place at the CNRS in Grenoble, France, in a very favourable environment for structural biology.


year authors and title journal last update
List of publications.
2018 Lucie Polovinkin, Ghérici Hassaine, Jonathan Perot, Emmanuelle Neumann, Anders A. Jensen, Solène N. Lefebvre, Pierre-Jean Corringer, Jacques Neyton, Christophe Chipot, Francois Dehez, Guy Schoehn, Hugues Nury
Conformational transitions of the serotonin 5-HT3 receptor
published pages: 275-279, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0672-3
Nature 563/7730 2020-02-06
2017 Ghérici Hassaïne, Cédric Deluz, Luigino Grasso, Romain Wyss, Ruud Hovius, Henning Stahlberg, Takashi Tomizaki, Aline Desmyter, Christophe Moreau, Lucie Peclinovska, Sonja Minniberger, Lamia Mebarki, Xiao-Dan Li, Horst Vogel, Hugues Nury
Expression, Biochemistry, and Stabilization with Camel Antibodies of Membrane Proteins: Case Study of the Mouse 5-HT3 Receptor
published pages: 139-168, ISSN: , DOI: 10.1007/978-1-4939-7151-0_8
Methods in Molecular Biology, Membrane Protein Structure and Function Characterization 2019-05-29

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