Opendata, web and dolomites

PentaBrain SIGNED

Structural studies of mammalian Cys-loop receptors

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PentaBrain project word cloud

Explore the words cloud of the PentaBrain project. It provides you a very rough idea of what is the project "PentaBrain" about.

opening    gaba    time    transient    mediate    ion    glycine    signal    environment    operation    benzodiazepines    mammalian    biomedical    plasma    missing    binding    structural    physiological    acutely    resolution    legion    activated    neurotransmission    function    allosteric    undergo    place    proposes    cristallo    movie    preliminary    therapeutic    mouse    extracellular    loop    nicotine    serotonin    invertebrate    first    homologues    understand    grenoble    receptors    gating    site    solved    emetics    modulators    crystallization    decipher    drugs    anaesthetics    body    intrinsic    molecules    active    neurotransmitter    solid    pharmacology    antibody    transitions    bacterial    conformational    family    psycho    transition    transducers    acetylcholine    membrane    record    france    cys    fast    compounds    advantage    brain    chaperones    receptor    structures    obtain    starting    limited    cnrs    mechanism    anti    molecular    channel    biology    atomic   

Project "PentaBrain" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2020-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙500˙000.00

Map

 Project objective

In the brain, Cys-loop receptors mediate fast neurotransmission. They function as allosteric signal transducers across the plasma membrane: upon binding of one or more neurotransmitter molecules to an extracellular site, the receptors undergo complex conformational transitions that result in transient opening of an intrinsic ion channel. The Cys-loop family comprises receptors activated by serotonin, acetylcholine, glycine and GABA. Mammalian receptors are also the targets of a legion of psycho-active and therapeutic compounds (including nicotine, benzodiazepines, anti-emetics, general anaesthetics). Our structural knowledge is currently limited to invertebrate homologues. Atomic structures mammalian receptors are therefore acutely missing in order to understand their physiological role in molecular terms, and to be able to develop new drugs targeting them.

The project proposes to decipher the operation mechanism, the pharmacology and conformational transitions of mammalian Cys-loop receptors. Starting with a solid body of preliminary results, we will obtain new high-resolution structures, taking advantage of antibody-based crystallization chaperones. We will try and record for the first time a ‘molecular movie’ of the gating conformational transition in cristallo. On the way, we will also investigate the potential of antibody-based modulators of Cys-loop receptors for biomedical applications.

The applicant has solved in the past the structures of a bacterial Cys-loop receptor and of the mouse serotonin receptor. The proposed research will take place at the CNRS in Grenoble, France, in a very favourable environment for structural biology.

 Publications

year authors and title journal last update
List of publications.
2018 Lucie Polovinkin, Ghérici Hassaine, Jonathan Perot, Emmanuelle Neumann, Anders A. Jensen, Solène N. Lefebvre, Pierre-Jean Corringer, Jacques Neyton, Christophe Chipot, Francois Dehez, Guy Schoehn, Hugues Nury
Conformational transitions of the serotonin 5-HT3 receptor
published pages: 275-279, ISSN: 0028-0836, DOI: 10.1038/s41586-018-0672-3
Nature 563/7730 2020-02-06
2017 Ghérici Hassaïne, Cédric Deluz, Luigino Grasso, Romain Wyss, Ruud Hovius, Henning Stahlberg, Takashi Tomizaki, Aline Desmyter, Christophe Moreau, Lucie Peclinovska, Sonja Minniberger, Lamia Mebarki, Xiao-Dan Li, Horst Vogel, Hugues Nury
Expression, Biochemistry, and Stabilization with Camel Antibodies of Membrane Proteins: Case Study of the Mouse 5-HT3 Receptor
published pages: 139-168, ISSN: , DOI: 10.1007/978-1-4939-7151-0_8
Methods in Molecular Biology, Membrane Protein Structure and Function Characterization 2019-05-29

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PENTABRAIN" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PENTABRAIN" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

HYPATIA (2019)

Privacy and Utility Allied

Read More  

QUBE (2019)

Quantum technology with carbon nanotUBEs

Read More  

AdaptiveResponse (2018)

The evolution of adaptive response mechanisms

Read More