Explore the words cloud of the QUANTPATTERN project. It provides you a very rough idea of what is the project "QUANTPATTERN" about.
The following table provides information about the project.
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
|Coordinator Country||Germany [DE]|
|Total cost||1˙499˙750 €|
|EC max contribution||1˙499˙750 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-07-01 to 2020-06-30|
Take a look of project's partnership.
|1||MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV||DE (MUENCHEN)||coordinator||1˙499˙750.00|
How an initially homogenous population of cells self-organizes to form patterned embryos and tissues is a long-standing mystery in the field of developmental biology. Understanding such self-organizing processes is of central importance for regenerative medicine and would inform approaches to transform embryonic stem cells into complex multicellular structures for human tissue replacement. The influential reaction-diffusion model postulates that patterns emerge during development under the influence of poorly diffusive activators and highly diffusive inhibitors, and we have recently found biophysical evidence supporting the differential diffusivity of the activator Nodal and its inhibitor Lefty in zebrafish embryos. While we have begun to define the Nodal/Lefty activator-inhibitor pair as a reaction-diffusion system that can transform a uniform field of cells into an embryo, three important questions remain: First, how is the differential diffusivity of activators and inhibitors achieved in living embryos? The molecular weights of activator and inhibitor proteins are too similar to explain the difference in diffusivities. Second, how do reaction-diffusion systems adapt to tissue size? Embryos can vary considerably in size, but the proportions of their body plans are remarkably constant. How reaction-diffusion systems mediate this scale-invariant patterning in vivo is unknown. Third, how do reaction-diffusion systems self-organize? Embryos are often born with maternally provided prepatterns, and it is unknown whether reaction-diffusion systems also form relevant patterns in the absence of such prepatterns. We will address these questions in zebrafish and mouse embryonic stem cells by combining innovative quantitative experimentation and mathematical modeling. This high-risk/high-gain approach will allow us to unravel general principles underlying self-organizing processes and will inform new strategies for human tissue engineering from embryonic stem cells.
|year||authors and title||journal||last update|
David MÃ¶rsdorf, Patrick MÃ¼ller
Tuning Protein Diffusivity with Membrane Tethers
published pages: 177-181, ISSN: 0006-2960, DOI: 10.1021/acs.biochem.8b01150
Daniel ÄŒapek, Patrick MÃ¼ller
Positional information and tissue scaling during development and regeneration
published pages: dev177709, ISSN: 0950-1991, DOI: 10.1242/dev.177709
Xavier Diego, Luciano Marcon, Patrick MÃ¼ller, James Sharpe
Key Features of Turing Systems are Determined Purely by Network Topology
published pages: , ISSN: 2160-3308, DOI: 10.1103/PhysRevX.8.021071
|Physical Review X 8/2||2019-05-29|
Alexander BlÃ¤ÃŸle, Gary Soh, Theresa Braun, David MÃ¶rsdorf, Hannes PreiÃŸ, Ben M. Jordan, Patrick MÃ¼ller
Quantitative diffusion measurements using the open-source software PyFRAP
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03975-6
|Nature Communications 9/1||2019-05-29|
Luciano Marcon, Xavier Diego, James Sharpe, Patrick MÃ¼ller
High-throughput mathematical analysis identifies Turing networks for patterning with equally diffusing signals
published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.14022
MarÃa Almuedo-Castillo, Alexander BlÃ¤ÃŸle, David MÃ¶rsdorf, Luciano Marcon, Gary H. Soh, Katherine W. Rogers, Alexander F. Schier, Patrick MÃ¼ller
Scale-invariant patterning by size-dependent inhibition of Nodal signalling
published pages: , ISSN: 1465-7392, DOI: 10.1038/s41556-018-0155-7
|Nature Cell Biology||2019-05-29|
Katherine W. Rogers, Patrick MÃ¼ller
Nodal and BMP dispersal during early zebrafish development
published pages: , ISSN: 0012-1606, DOI: 10.1016/j.ydbio.2018.04.002
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "QUANTPATTERN" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (email@example.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "QUANTPATTERN" are provided by the European Opendata Portal: CORDIS opendata.