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BIOSUSAMIN SIGNED

The design and development of efficient biocatalytic cascades and biosynthetic pathways for the sustainable production of amines

Total Cost €

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EC-Contrib. €

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Partnership

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Project "BIOSUSAMIN" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT VAN AMSTERDAM 

Organization address
address: SPUI 21
city: AMSTERDAM
postcode: 1012WX
website: www.uva.nl

contact info
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name: n.a.
surname: n.a.
function: n.a.
email: n.a.
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 Coordinator Country Netherlands [NL]
 Project website http://www.hims-biocat.eu
 Total cost 1˙497˙270 €
 EC max contribution 1˙497˙270 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT VAN AMSTERDAM NL (AMSTERDAM) coordinator 1˙461˙840.00
2    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) participant 35˙430.00

Map

 Project objective

The objective of this project is to design and develop biocatalytic cascades, using purified enzymes in vitro, as well as biosynthetic pathways in whole cell microbial organisms. These biocatalytic cascades and biosynthetic pathways will be developed for the synthesis of chiral and achiral amines that are of particular interest for the chemical industry. The amine functionality will be introduced using amine dehydrogenases (AmDHs) as biocatalysts in the pivotal core enzymatic step. AmDHs are a new class of enzymes that have recently been obtained by protein engineering of wild-type amino acid dehydrogenases. However, only two AmDHs have been generated so far and, moreover, they show a limited substrate scope. Therefore protein engineering will be undertaken in order to expand the substrate scope of the already existing AmDHs. In addition, novel AmDHs will be generated starting from different wild-type amino acid dehydrogenases as scaffolds, whose amino acid and DNA sequences are available in databases, literature, libraries, etc. In particular, protein engineering will be focused on the specific chemical targets that are the objectives of the designed biocatalytic cascades and in addition, screening for more diverse substrates will also be carried out. Finally, the AmDHs will be used in combination with other enzymes such as alcohol dehydrogenases, oxidases, alkane monooxygenases, etc., to deliver variously functionalised amines and derivatives as final products with elevated yields, perfect chemo- regio- and stereoselectivity, enhanced atom efficiency and minimum environmental impact. Such an approach will be realised through the design of new pathways that will convert inexpensive starting materials from renewable resources, encompassing the internal recycling of redox equivalents, the use of inorganic ammonia as nitrogen source and, if necessary, only molecular oxygen as the innocuous additional oxidant. Water will be the sole by-product.

 Publications

year authors and title journal last update
List of publications.
2017 Tanja Knaus, Wesley B?hmer, Francesco G. Mutti
Amine dehydrogenases: efficient biocatalysts for the reductive amination of carbonyl compounds
published pages: 453-463, ISSN: 1463-9262, DOI: 10.1039/C6GC01987K
Green Chem. 19/2 2020-04-23
2017 Tanja Knaus, Luca Cariati, Marcelo F. Masman, Francesco G. Mutti
In vitro biocatalytic pathway design: orthogonal network for the quantitative and stereospecific amination of alcohols
published pages: 8313-8325, ISSN: 1477-0520, DOI: 10.1039/C7OB01927K
Organic & Biomolecular Chemistry 15/39 2020-04-23
2016 Tanja Knaus, Caroline E. Paul, Colin W. Levy, Simon de Vries, Francesco G. Mutti, Frank Hollmann, Nigel S. Scrutton
Better than Nature: Nicotinamide Biomimetics That Outperform Natural Coenzymes
published pages: 1033-1039, ISSN: 0002-7863, DOI: 10.1021/jacs.5b12252
Journal of the American Chemical Society 138/3 2020-04-23
2015 F. G. Mutti, T. Knaus, N. S. Scrutton, M. Breuer, N. J. Turner
Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades
published pages: 1525-1529, ISSN: 0036-8075, DOI: 10.1126/science.aac9283
Science 349/6255 2020-04-23
2017 Tanja Knaus, Francesco G. Mutti
Biocatalytic hydrogen-borrowing cascades
published pages: 34-37, ISSN: 0392-839X, DOI:
Chimica Oggi - Chemistry Today 6 times per year 2020-04-23
2018 Jan Vilím, Tanja Knaus, Francesco G. Mutti
Catalytic Promiscuity of Galactose Oxidase: A Mild Synthesis of Nitriles from Alcohols, Air, and Ammonia
published pages: 14240-14244, ISSN: 1433-7851, DOI: 10.1002/anie.201809411
Angewandte Chemie International Edition 57/43 2020-04-23
2018 Tanja Knaus, Vasilis Tseliou, Luke D. Humphreys, Nigel S. Scrutton, Francesco G. Mutti
A biocatalytic method for the chemoselective aerobic oxidation of aldehydes to carboxylic acids
published pages: 3931-3943, ISSN: 1463-9262, DOI: 10.1039/C8GC01381K
Green Chemistry 20/17 2020-04-23
2018 Maria L. Corrado, Tanja Knaus, Francesco G. Mutti
A Chimeric Styrene Monooxygenase with Increased Efficiency in Asymmetric Biocatalytic Epoxidation
published pages: 679-686, ISSN: 1439-4227, DOI: 10.1002/cbic.201700653
ChemBioChem 19/7 2020-04-23

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