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LysoMod SIGNED

Genetic and Small Molecule Modifiers of Lysosomal Function

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

LysoMod project word cloud

Explore the words cloud of the LysoMod project. It provides you a very rough idea of what is the project "LysoMod" about.

academic cross age participant neurodegenerative regulation rapid gene human linked lsd mechanisms young expression drugs personalized lysosome people led genes medicinal lsds action signalling drug variety expertise biological dysfunction generation disorder talk staff trials candidate public strategies prioritising exchange mouse cells lysosomes diagnostics cell pathology implementing innovate lysosomal therapeutic training therapies diseases preparing proteomics health modifier complementary approved critical function ranging area clinical exploring biochemistry storage companies genetics collaborative either careers medicine sectors life lipidomics transcriptomics innovative biology biomedical play mentored quality private transfer pharmacology multidisciplinary lysomod pioneer optimize rnas disorders chemistry

Project "LysoMod" data sheet

The following table provides information about the project.

Coordinator	INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES Organization address address: AVENIDA PROF EGAS MONIZ city: LISBOA postcode: 1649 028 website: www.imm.ul.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Portugal [PT]
Project website	https://lysomod.wixsite.com/lysomod
Total cost	1˙156˙500 €
EC max contribution	1˙102˙500 € (95%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2016
Funding Scheme	MSCA-RISE
Starting year	2017
Duration (year-month-day)	from 2017-03-01 to 2021-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES INSTITUTO DE MEDICINA MOLECULAR JOAO LOBO ANTUNES Organization address address: AVENIDA PROF EGAS MONIZ city: LISBOA postcode: 1649 028 website: www.imm.ul.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBOA)	coordinator	366˙300.00
2	GENOMED, DIAGNOSTICOS DE MEDICINA MOLECULAR SA GENOMED, DIAGNOSTICOS DE MEDICINA MOLECULAR SA Organization address address: AVENIDA PROFESSOR EGAS MONIZ city: LISBOA postcode: 1600 190 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBOA)	participant	240˙750.00
3	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (OXFORD)	participant	198˙000.00
4	INSTITUTUL DE BIOCHIMIE INSTITUTUL DE BIOCHIMIE Organization address address: SPLAIUL INDEPENDENTEI NO. 296 city: BUCHAREST postcode: 60031 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	RO (BUCHAREST)	participant	130˙500.00
5	CHRONOS BIOSYSTEMS SRL CHRONOS BIOSYSTEMS SRL Organization address address: BULEVARDUL GENIULUI, NR 34, PARTER, CAMERA 2 city: Bucharest postcode: 60117 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	RO (Bucharest)	participant	108˙000.00
6	INTRABIO LTD INTRABIO LTD Organization address address: SUMMIT HOUSE, 170 FINCHLEY ROAD, city: LONDON postcode: NW3 6BP website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	27˙000.00
7	WEIZMANN INSTITUTE OF SCIENCE WEIZMANN INSTITUTE OF SCIENCE Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 website: www.weizmann.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (REHOVOT)	participant	18˙450.00
8	THE UNIVERSITY OF SUSSEX THE UNIVERSITY OF SUSSEX Organization address address: SUSSEX HOUSE FALMER city: BRIGHTON postcode: BN1 9RH website: http://www.sussex.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BRIGHTON)	participant	13˙500.00
9	FONDAZIONE TELETHON FONDAZIONE TELETHON Organization address address: VIA VARESE 16/B city: ROMA postcode: 185 website: www.telethon.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	0.00
10	LIPOTYPE LIPOTYPE Organization address address: TATZBERG 47 city: DRESDEN postcode: 1307 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DRESDEN)	participant	0.00
11	PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE PONTIFICIA UNIVERSIDAD CATOLICA DE CHILE Organization address address: AVENIDA LIBERTADOR BERNARDO O'HIGGINS 340 city: SANTIAGO postcode: 8331150 website: www.uc.cl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CL (SANTIAGO)	partner	0.00
12	THE CHILDREN'S HOSPITAL OF PHILADELPHIA NON PROFIT ORG THE CHILDREN'S HOSPITAL OF PHILADELPHIA NON PROFIT ORG Organization address address: Civic Center Blvd city: Philadelphia postcode: 19104 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (Philadelphia)	partner	0.00
13	UNIVERSIDAD DE BUENOS AIRES UNIVERSIDAD DE BUENOS AIRES Organization address address: CALLE VIAMONTE 430 city: BUENOS AIRES postcode: 1053 website: www.uba.ar contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AR (BUENOS AIRES)	partner	0.00
14	UNIVERSIDAD DEL DESARROLLO UNIVERSIDAD DEL DESARROLLO Organization address address: AV LA PLAZA 700 city: SAN CARLOS DE APOQUINDO postcode: n.a. website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CL (SAN CARLOS DE APOQUINDO)	partner	0.00

Map

Project objective

LysoMod will innovate in the area of personalized medicine for disorders linked to lysosomal dysfunction. This will be achieved by implementing a collaborative staff-exchange program between highly complementary and multidisciplinary academic and non-academic partners with expertise in pharmacology, medicinal chemistry, cell biology, biochemistry, mouse and human genetics, transcriptomics, proteomics and lipidomics. Based on the critical role that lysosomes play in cells, a better understanding of lysosomal function will have a major impact on human health, fostering the development of new strategies to improve quality of life for people affected by a variety of diseases, ranging from lysosomal storage diseases (LSDs) to age-related neurodegenerative disorders. LysoMod’s specific objectives are: 1) to develop and further optimize existing therapies for LSDs; 2) to identify new targets for personalized therapies for LSDs; and 3) to investigate the cross-talk between lysosomal function, signalling pathways and gene expression regulation. The pioneer work of a participant in the consortium led to the development of a drug that is approved for clinical use. LysoMod will i) investigate the mechanisms of action of this and other drugs in lysosome-related disorder; ii) identify modifier genes involved in LSD pathology and test their potential as new targets for personalized therapeutic approaches; iii) identify candidate RNAs that can be targeted to enhance lysosomal function. The companies in the consortium will ensure a rapid transfer of new knowledge into applications for diagnostics and clinical trials. Prioritising lysosomal dysfunction as a highly relevant biomedical problem, the LysoMod consortium will implement a mentored staff-exchange program to provide young researchers with high-level training in innovative approaches for exploring biological systems, preparing the next generation of researchers for careers either in the private or public health sectors.

Deliverables

List of deliverables.
Organization of a summer school in Chile	Other	2020-03-03 15:05:06
Project Website Internet-based social media	Websites, patent fillings, videos etc.	2020-03-03 15:05:06

Take a look to the deliverables list in detail: detailed list of LysoMod deliverables.

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The information about "LYSOMOD" are provided by the European Opendata Portal: CORDIS opendata.

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