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SCORA SIGNED

A systematic characterization of human regulatory architectures and their determinants of regulatory activity

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EC-Contrib. €

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Project "SCORA" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://anderssonlab.org
 Total cost 1˙436˙292 €
 EC max contribution 1˙436˙292 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 1˙249˙225.00
2    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) participant 103˙590.00
3    ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING MCGILL UNIVERSITY CA (MONTREAL) participant 60˙352.00
4    KLINIKUM DER UNIVERSITAET ZU KOELN DE (KOELN) participant 23˙125.00

Map

 Project objective

Enhancers control the correct spatio-temporal activation of gene expression. A comprehensive characterization of the properties and regulatory activities of enhancers as well as their target genes is therefore crucial to understand the regulation and dysregulation of differentiation, homeostasis and cell type specificity. Genome-wide chromatin assays have provided insight into the properties and complex architectures by which enhancers regulate genes, but the understanding of their mechanisms is fragmented and their regulatory targets are mostly unknown. Several factors may confound the inference and interpretation of regulatory enhancer activity. There are likely many kinds of regulatory architectures with distinct levels of output and flexibility. Despite this, most state-of-the-art genome-wide studies only consider a single model. In addition, chromatin-based analysis alone does not provide clear insight into function or activity. This project aims to systematically characterize enhancer architectures and delineate what determines their: (1) restricted spatio-temporal activity; (2) robustness to regulatory genetic variation; and (3) dynamic activities over time. My work has shown enhancer transcription to be the most accurate classifier of enhancer activity to date. This data permits unprecedented modeling of regulatory architectures via enhancer-promoter co-expression linking. Careful computational analysis of such data from appropriate experimental systems has a great potential for distinguishing the different modes of regulation and their functional impact. The outcomes have great potential for providing us with new insights into mechanisms of transcriptional regulation. The results will be particularly relevant to interpretation of regulatory genetic variations. Ultimately, knowing the characteristics and conformations of enhancer architectures will increase our ability to link variation in non-coding DNA to phenotypic outcomes like disease susceptibility.

 Publications

year authors and title journal last update
List of publications.
2018 Nataliya Petryk, Maria Dalby, Alice Wenger, Caroline B. Stromme, Anne Strandsby, Robin Andersson, Anja Groth
MCM2 promotes symmetric inheritance of modified histones during DNA replication
published pages: 1389-1392, ISSN: 0036-8075, DOI: 10.1126/science.aau0294
Science 361/6409 2020-04-14
2018 Mette Boyd, Malte Thodberg, Morana Vitezic, Jette Bornholdt, Kristoffer Vitting-Seerup, Yun Chen, Mehmet Coskun, Yuan Li, Bobby Zhao Sheng Lo, Pia Klausen, Pawel Jan Schweiger, Anders Gorm Pedersen, Nicolas Rapin, Kerstin Skovgaard, Katja Dahlgaard, Robin Andersson, Thilde Bagger Terkelsen, Berit Lilje, Jesper Thorvald Troelsen, Andreas Munk Petersen, Kim Bak Jensen, Ismail Gögenur, Peter Thielsen, Jakob Benedict Seidelin, Ole Haagen Nielsen, Jacob Tveiten Bjerrum, Albin Sandelin
Characterization of the enhancer and promoter landscape of inflammatory bowel disease from human colon biopsies
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-03766-z
Nature Communications 9/1 2020-04-14
2018 Niels Grarup, Ida Moltke, Mette K. Andersen, Maria Dalby, Kristoffer Vitting-Seerup, Timo Kern, Yuvaraj Mahendran, Emil Jørsboe, Christina V. L. Larsen, Inger K. Dahl-Petersen, Arthur Gilly, Daniel Suveges, George Dedoussis, Eleftheria Zeggini, Oluf Pedersen, Robin Andersson, Peter Bjerregaard, Marit E. Jørgensen, Anders Albrechtsen, Torben Hansen
Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes
published pages: 172-174, ISSN: 1061-4036, DOI: 10.1038/s41588-017-0022-7
Nature Genetics 50/2 2020-04-14
2016 Jenna Persson, Babett Steglich, Agata Smialowska, Mette Boyd, Jette Bornholdt, Robin Andersson, Catherine Schurra, Benoit Arcangioli, Albin Sandelin, Olaf Nielsen, Karl Ekwall
Regulating retrotransposon activity through the use of alternative transcription start sites
published pages: 753-768, ISSN: 1469-221X, DOI: 10.15252/embr.201541866
EMBO reports 17/5 2020-04-14
2018 Sarah Rennie, Maria Dalby, Marta Lloret-Llinares, Stylianos Bakoulis, Christian Dalager Vaagensø, Torben Heick Jensen, Robin Andersson
Transcription start site analysis reveals widespread divergent transcription in D. melanogaster and core promoter-encoded enhancer activities
published pages: , ISSN: 0305-1048, DOI: 10.1093/nar/gky244
Nucleic Acids Research 2020-04-14
2018 J. Kenneth Baillie, Andrew Bretherick, Christopher S. Haley, Sara Clohisey, Alan Gray, Lucile P. A. Neyton, Jeffrey Barrett, Eli A. Stahl, Albert Tenesa, Robin Andersson, J. Ben Brown, Geoffrey J. Faulkner, Marina Lizio, Ulf Schaefer, Carsten Daub, Masayoshi Itoh, Naoto Kondo, Timo Lassmann, Jun Kawai, Damian Mole, Vladimir B. Bajic, Peter Heutink, Michael Rehli, Hideya Kawaji, Albin Sandelin, Harukazu Suzuki, Jack Satsangi, Christine A. Wells, Nir Hacohen, Thomas C. Freeman, Yoshihide Hayashizaki, Piero Carninci, Alistair R. R. Forrest, David A. Hume
Shared activity patterns arising at genetic susceptibility loci reveal underlying genomic and cellular architecture of human disease
published pages: e1005934, ISSN: 1553-7358, DOI: 10.1371/journal.pcbi.1005934
PLOS Computational Biology 14/3 2020-04-14
2018 Sarah Rennie, Maria Dalby, Lucas van Duin, Robin Andersson
Transcriptional decomposition reveals active chromatin architectures and cell specific regulatory interactions
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-02798-1
Nature Communications 9/1 2020-04-14
2015 Robin Andersson, Yun Chen, Leighton Core, John T. Lis, Albin Sandelin, Torben Heick Jensen
Human Gene Promoters Are Intrinsically Bidirectional
published pages: 346-347, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2015.10.015
Molecular Cell 60/3 2020-04-14
2016 Yun Chen, Athma A Pai, Jan Herudek, Michal Lubas, Nicola Meola, Aino I Järvelin, Robin Andersson, Vicent Pelechano, Lars M Steinmetz, Torben Heick Jensen, Albin Sandelin
Principles for RNA metabolism and alternative transcription initiation within closely spaced promoters
published pages: 984-994, ISSN: 1061-4036, DOI: 10.1038/ng.3616
Nature Genetics 48/9 2020-04-14
2015 Robin Andersson, Albin Sandelin, Charles G. Danko
A unified architecture of transcriptional regulatory elements
published pages: 426-433, ISSN: 0168-9525, DOI: 10.1016/j.tig.2015.05.007
Trends in Genetics 31/8 2020-04-14

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