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CIRCUITASSEMBLY SIGNED

Development of functional organization of the visual circuits in mice

Total Cost €

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EC-Contrib. €

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Partnership

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Project "CIRCUITASSEMBLY" data sheet

The following table provides information about the project.

Coordinator
AARHUS UNIVERSITET 

Organization address
address: NORDRE RINGGADE 1
city: AARHUS C
postcode: 8000
website: www.au.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://www.yoneharalab.com/
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2020-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AARHUS UNIVERSITET DK (AARHUS C) coordinator 1˙500˙000.00

Map

 Project objective

The key organizing principles that characterize neuronal systems include asymmetric, parallel, and topographic connectivity of the neural circuits. The main aim of my research is to elucidate the key principles underlying functional development of neural circuits by focusing on those organizing principles. I choose mouse visual system as my model since it contains all of these principles and provides sophisticated genetic tools to label and manipulate individual circuit components. My research is based on the central hypothesis that the mechanisms of brain development cannot be fully understood without first identifying individual functional cell types in adults, and then understanding how the functions of these cell types become established, using cell-type-specific molecular and synaptic mechanisms in developing animals. Recently, I have identified several transgenic mouse lines in which specific cell types in a visual center, the superior colliculus, are labeled with Cre recombinase in both developing and adult animals. Here I will take advantage of these mouse lines to ask fundamental questions about the functional development of neural circuits. First, how are distinct sensory features processed by the parallel topographic neuronal pathways, and how do they contribute to behavior? Second, what are the molecular and synaptic mechanisms that underlie developmental circuit plasticity for forming parallel topographic neuronal maps in the brain? Third, what are the molecular mechanisms that set up spatially asymmetric circuit connectivity without the need for sensory experience? I predict that my insights into the developmental mechanism of asymmetric, parallel, and topographic connectivity and circuit plasticity will be instructive when studying other brain circuits which contain similar organizing principles.

 Publications

year authors and title journal last update
List of publications.
2017 Rune Rasmussen, Keisuke Yonehara
Circuit Mechanisms Governing Local vs. Global Motion Processing in Mouse Visual Cortex
published pages: , ISSN: 1662-5110, DOI: 10.3389/fncir.2017.00109
Frontiers in Neural Circuits 11 2019-12-16
2018 Ana F. Oliveira, Keisuke Yonehara
The Mouse Superior Colliculus as a Model System for Investigating Cell Type-Based Mechanisms of Visual Motor Transformation
published pages: , ISSN: 1662-5110, DOI: 10.3389/fncir.2018.00059
Frontiers in Neural Circuits 12 2019-12-16
2019 Akihiro Matsumoto, Kevin L. Briggman, Keisuke Yonehara
Spatiotemporally Asymmetric Excitation Supports Mammalian Retinal Motion Sensitivity
published pages: 3277-3288.e5, ISSN: 0960-9822, DOI: 10.1016/j.cub.2019.08.048
Current Biology 29/19 2019-12-16
2016 Keisuke Yonehara, Michele Fiscella, Antonia Drinnenberg, Federico Esposti, Stuart Trenholm, Jacek Krol, Felix Franke, Brigitte Gross Scherf, Akos Kusnyerik, Jan Müller, Arnold Szabo, Josephine Jüttner, Francisco Cordoba, Ashrithpal Police Reddy, János Németh, Zoltán Zsolt Nagy, Francis Munier, Andreas Hierlemann, Botond Roska
Congenital Nystagmus Gene FRMD7 Is Necessary for Establishing a Neuronal Circuit Asymmetry for Direction Selectivity
published pages: 177-193, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2015.11.032
Neuron 89/1 2019-05-29

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