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BetaDropNMR SIGNED

Ultra-sensitive NMR in liquids

Total Cost €

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EC-Contrib. €

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Partnership

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 BetaDropNMR project word cloud

Explore the words cloud of the BetaDropNMR project. It provides you a very rough idea of what is the project "BetaDropNMR" about.

acids    resonance    mg2    spectroscopy    interaction    solid    suitable    probe    orders    nucleic    chemical    constraints    firm    revealing    questions    half    situation    science    enlarging    atmospheric    complexes    limitations    dynamics    chemistry    ultra    nuclei    bonding    zn2    vacuum    contain    mechanism    human    pose    liquid    envisage    provides    body    extremely    material    basis    metal    applicable    magnetic    fact    techniques    tool    giving    motivated    proteins    successfully    placed    nmr    sensitivity    particles    configuration    toolbox    pressure    spin    spectroscopically    silent    influencing    universal    never    versatile    overcoming    decay    periodic    cu    soft    environments    respect    limited    powerful    samples    create    interacting    amount    physics    dozens    anisotropic    magnitude    otherwise    biology    sensitive    ions    electronic    first    small    breaking    polarized    oxidation    beta    explored    biochemistry    structure    relies    ground    difficult    table    nuclear    conventional    emission    severe   

Project "BetaDropNMR" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH 

Organization address
address: ESPLANADE DES PARTICULES 1 PARCELLE 11482 DE MEYRIN BATIMENT CADASTRAL 1046
city: GENEVA 23
postcode: 1211
website: www.cern.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN ORGANIZATION FOR NUCLEAR RESEARCH CH (GENEVA 23) coordinator 1˙500˙000.00

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 Project objective

'The nuclear magnetic resonance spectroscopy (NMR) is a versatile and powerful tool, especially in chemistry and in biology. However, its limited sensitivity and small amount of suitable probe nuclei pose severe constraints on the systems that may be explored. This project aims at overcoming the above limitations by giving NMR an ultra-high sensitivity and by enlarging the NMR 'toolbox' to dozens of nuclei across the periodic table. This will be achieved by applying the β-NMR method to the soft matter samples. The method relies on anisotropic emission of β particles in the decay of highly spin-polarized nuclei. This feature results in 10 orders of magnitude more sensitivity compared to conventional NMR and makes it applicable to elements which are otherwise difficult to investigate spectroscopically. β-NMR has been successfully applied in nuclear physics and material science in solid samples and high-vacuum environments, but never before to liquid samples placed in atmospheric pressure. With this novel approach I want to create a new universal and extremely sensitive tool to study various problems in biochemistry. The first questions which I envisage addressing with this ground-breaking and versatile method concern the interaction of essential metal ions, which are spectroscopically silent in most techniques, Mg2, Cu, and Zn2, with proteins and nucleic acids. The importance of these studies is well motivated by the fact that half of the proteins in our human body contain metal ions, but their interaction mechanism and factors influencing it are still not fully understood. In this respect NMR spectroscopy is of great help: it provides information on the structure, dynamics, and chemical properties of the metal complexes, by revealing the coordination number, oxidation state, bonding situation and electronic configuration of the interacting metal. My long-term aim is to establish a firm basis for β-NMR in soft matter studies in biology, chemistry and physics.'

 Publications

year authors and title journal last update
List of publications.
2018 M. Jankowski
Enabling beta-Decay Asymmetry Measurements onLiquid Samples at the Versatile Ion-PolarizationTechniques Online (VITO) Beam Line
published pages: , ISSN: , DOI:
Bachelor Thesis 2019-10-07
2018 M. Bissell1, R.F. Garcia-Ruiz1, W. Gins, M. Kowalska, G. Neyens2, S. Pallada, N. Severijns2, P. Velten2, F. Wienholtz, D. Zakoucky4, X.F. Yang2
Online commissioning of the laser-polarization setup at VITO
published pages: , ISSN: , DOI:
Letter of Intent to the ISOLDE and Neutron Time-of-Flight Committee CERN-INTC-2016-026 / INTC-I-168 2019-10-07
2017 M. Kowalska1, V. Araujo Escalona2, M. Baranowski3, L. Cerato4, M. Bissell4, W. Gins2, R. Grzywacz6, F. Gustafsson2, R. Harding, L. Hemmingsen8, F. Hofmann8, H. Heylen9, A. Kanellakopoulos2, V. Kocman10, M. Kozak3, M. Madurga Flores6, G. Neyens2, S. Pallada, J. Plavec10, N. Severijns2, D. Szunyogh8, K. Szutkowski3, P. Thulstrup8, M. Walczak11, F. Wienholtz, J. Wolak3, X.F. Yang2, D. Zakoucky12
Interaction of Na ions with DNA G-quadruplex structuresstudied directly with Na beta-NMR spectroscopy
published pages: , ISSN: , DOI:
Proposal to the ISOLDE and Time-of-Flight Committee CERN-INTC-2017-071 / INTC-P-521 2019-10-07
2018 M. Kowalska1, V. Araujo Escalona2, M. Baranowski3, J. Croese1,4, L. Cerato4, M. Bissell4, W. Gins2, F. Gustafsson2, R. Harding, L. Hemmingsen8, H. Heylen1, F. Hofmann8, A. Kanellakopoulos2, V. Kocman9, M. Kozak3, M. Madurga Flores6, G. Neyens1,2, S. Pallada, J. Plavec9, K. Szutkowski3, M. Walczak10, F. Wienholtz, J. Wolak3, X.F. Yang11, D. Zakoucky12
Interaction of Na+ ions with DNA G-quadruplex structures studied directlywith Na beta-NMR spectroscopy
published pages: , ISSN: , DOI:
Addendum to P-521 to the ISOLDE and Neutron Time-of-Flight Commit CERN-INTC-2018-019 / INTC-P-521 2019-10-07
2018 W. Gins, R. Harding, M. Baranowski, M. L. Bissell, M. Kowalska, G. Neyens, S. Pallada, N. Severijns, Ph. Velten, M. Walczak, F. Wienholtz, Z. Y. Xu, X. F. Yang, D. Zakoucky
The setup for laser spin-polarization at VITO-ISOLDE
published pages: , ISSN: , DOI:
To be submitted to: Nuclear Instruments and Methods in Physics A 2019-10-07
2018 S. Pallada, for IS645
First β-NMR experiments with liquids at VITO
published pages: 23, ISSN: , DOI:
ISOLDE Newsletter 2018 2019-10-07
2017 M Kowalska, P Aschenbrenner, M Baranowski, M L Bissell, W Gins, R D Harding, H Heylen, G Neyens, S Pallada, N Severijns, Ph Velten, M Walczak, F Wienholtz, Z Y Xu, X F Yang, D Zakoucky
New laser polarization line at the ISOLDE facility
published pages: 84005, ISSN: 0954-3899, DOI: 10.1088/1361-6471/aa77d7
Journal of Physics G: Nuclear and Particle Physics 44/8 2019-10-07
2017 Attila Jancso, Joao G Correia, Alexander Gottberg, Juliana Schell, Monika Stachura, Dániel Szunyogh, Stavroula Pallada, Doru C Lupascu, Magdalena Kowalska, Lars Hemmingsen
TDPAC and β -NMR applications in chemistry and biochemistry
published pages: 64003, ISSN: 0954-3899, DOI: 10.1088/1361-6471/aa666b
Journal of Physics G: Nuclear and Particle Physics 44/6 2019-10-07
2018 W. Gins, R. D. Harding, M. Baranowski, M. L. Bissell, R. F. Garcia Ruiz, M. Kowalska, G. Neyens, S. Pallada, N. Severijns, Ph. Velten, F. Wienholtz, Z. Y. Xu, X. F. Yang, D. Zakoucky
A new beamline for laser spin-polarization at ISOLDE
published pages: , ISSN: 0168-9002, DOI:
Nuclear Instruments and Methods A 2019-10-07
2018 M. Kowalska, V. Araujo Escalona, M. Baranowski3, J. Croese1,4, L. Cerato4, M. Bissell4, W. Gins2, F. Gustafsson2, R. Harding, L. Hemmingsen8, H. Heylen1, F. Hofmann, A. Kanellakopoulos, V. Kocman, M. Kozak, M. Madurga Flores, G. Neyens, S. Pallada, J. Plavec9, K. Szutkowski3, M. Walczak10, F. Wienholtz1, J. Wolak3, X.F. Yang11, D. Zakoucky1
Interaction of Na+ ions with DNA G-quadruplex structures studied directly with Na beta-NMR spectroscopy
published pages: , ISSN: , DOI:
CERN INTC Addendum to Proposal 2019-10-07

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