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A CACTUS

Antibody-free method for Counting All Circulating TUmour cellS while maintaining them alive and intact

Total Cost €

0

EC-Contrib. €

0

Partnership

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 A CACTUS project word cloud

Explore the words cloud of the A CACTUS project. It provides you a very rough idea of what is the project "A CACTUS" about.

enter    gastric    display    emulsions    count    metastases    instead    obvious    effect    commercialising    water    final    droplets    diagnostic    90    lactate    metabolic    environmental    counting    lung    microenvironment    sensitive    feasibility    consisting    veridex    cellsearch    deaths    circulating    presented    showed    liter    micro    critical    proper    proposition    tumour    influence    sites    volume    assays    responsible    dyes    proof    ip    provides    maintaining    portfolio    surrounding    breast    intact    investors    plan    isolate    detects    rate    progression    blood    detection    ph    business    glycolysis    fluidic    approved    patient    antibody    sorting    induce    enzymatic    strategy    stream    correctly    labelling    attractive    meant    cells    cactus    probing    oil    ctcs    outcome    cancer    alive    characterising    aerobic    ctc    warburg    treatment    epithelial    prostate    cytosol    metastatic    fda    idea    mesenchymal    pico    detected    colon    bladder    separating    inexpensive    detecting    commercialisation   

Project "A CACTUS" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITA DEGLI STUDI DI UDINE 

Organization address
address: VIA PALLADIO 8
city: UDINE
postcode: 33100
website: www.uniud.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Italy [IT]
 Total cost 149˙875 €
 EC max contribution 149˙875 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2016-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI UDINE IT (UDINE) coordinator 149˙875.00

Map

 Project objective

The problem: Cancer metastases are responsible for 90% of cancer-associated deaths. Circulating tumour cells (CTCs) that enter the blood stream on their way to potential metastatic sites are of obvious interest to evaluate correctly patient treatment and therefore influence outcome. CTCs have been identified in bladder, gastric, prostate, lung, breast and colon cancer. The only FDA approved CTCs detection system is Veridex’ CellSearch, which detects only epithelial cancer cells using antibody labelling. Recent evidence showed that non-epithelial cancer cells, which are not detected by CellSearch, are of critical importance in cancer progression.

The idea: Our CTC detection method is based, instead of on antibody labelling, on metabolic features of cancer cells, thus providing potential for detecting both epithelial and mesenchymal cancer cells. Cancer cells induce environmental changes; e.g. in aerobic conditions most cancer cells display a high rate of glycolysis with lactate production in the cytosol, known as the Warburg effect. By separating cells into micro-droplets of pico-liter volume using micro-fluidic water-in-oil emulsions and by characterising the microenvironment surrounding them, CTCs are detected by probing for environmental changes using pH sensitive dyes or enzymatic lactate assays. Our inexpensive diagnostic method provides a way to count and isolate CTCs without any labelling while maintaining cells alive and intact for further studies.

The project: “A CACTUS” is meant to assess the feasibility of commercialising the developed method for counting and sorting CTCs and develop a proper commercialisation strategy. The final goal of this project is to develop a proposition package consisting of technical proof of concept, the business proposition and strategy and an IP portfolio and strategy. This information will be presented in an attractive business plan that will be proposed to potential investors.

 Publications

year authors and title journal last update
List of publications.
2016 Fabio Del Ben, Matteo Turetta, Giorgia Celetti, Aigars Piruska, Michela Bulfoni, Daniela Cesselli, Wilhelm T. S. Huck, Giacinto Scoles
A Method for Detecting Circulating Tumor Cells Based on the Measurement of Single-Cell Metabolism in Droplet-Based Microfluidics
published pages: 8581-8584, ISSN: 1433-7851, DOI: 10.1002/anie.201602328 		Angewandte Chemie International Edition 55/30 2019-07-23

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