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A CACTUS

Antibody-free method for Counting All Circulating TUmour cellS while maintaining them alive and intact

Total Cost €

0

EC-Contrib. €

0

Partnership

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 A CACTUS project word cloud

Explore the words cloud of the A CACTUS project. It provides you a very rough idea of what is the project "A CACTUS" about.

progression    probing    metabolic    aerobic    display    detects    prostate    pico    sensitive    critical    90    counting    presented    treatment    cancer    responsible    effect    meant    separating    enzymatic    provides    ip    instead    business    water    induce    sorting    lactate    influence    ctcs    warburg    glycolysis    breast    attractive    deaths    liter    proper    maintaining    detected    diagnostic    characterising    cells    antibody    gastric    oil    strategy    correctly    bladder    detecting    isolate    dyes    ph    emulsions    stream    alive    cellsearch    droplets    circulating    investors    mesenchymal    cytosol    cactus    feasibility    count    inexpensive    patient    plan    idea    consisting    environmental    micro    obvious    proof    portfolio    veridex    metastatic    detection    fda    intact    sites    blood    rate    commercialisation    fluidic    tumour    proposition    surrounding    final    epithelial    commercialising    colon    labelling    ctc    volume    enter    showed    approved    outcome    metastases    assays    lung    microenvironment   

Project "A CACTUS" data sheet

The following table provides information about the project.

Coordinator		 UNIVERSITA DEGLI STUDI DI UDINE 

Organization address
address: VIA PALLADIO 8
city: UDINE
postcode: 33100
website: www.uniud.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Italy [IT]
 Total cost 149˙875 €
 EC max contribution 149˙875 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-PoC
 Funding Scheme ERC-POC
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2016-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI UDINE IT (UDINE) coordinator 149˙875.00

Map

 Project objective

The problem: Cancer metastases are responsible for 90% of cancer-associated deaths. Circulating tumour cells (CTCs) that enter the blood stream on their way to potential metastatic sites are of obvious interest to evaluate correctly patient treatment and therefore influence outcome. CTCs have been identified in bladder, gastric, prostate, lung, breast and colon cancer. The only FDA approved CTCs detection system is Veridex’ CellSearch, which detects only epithelial cancer cells using antibody labelling. Recent evidence showed that non-epithelial cancer cells, which are not detected by CellSearch, are of critical importance in cancer progression.

The idea: Our CTC detection method is based, instead of on antibody labelling, on metabolic features of cancer cells, thus providing potential for detecting both epithelial and mesenchymal cancer cells. Cancer cells induce environmental changes; e.g. in aerobic conditions most cancer cells display a high rate of glycolysis with lactate production in the cytosol, known as the Warburg effect. By separating cells into micro-droplets of pico-liter volume using micro-fluidic water-in-oil emulsions and by characterising the microenvironment surrounding them, CTCs are detected by probing for environmental changes using pH sensitive dyes or enzymatic lactate assays. Our inexpensive diagnostic method provides a way to count and isolate CTCs without any labelling while maintaining cells alive and intact for further studies.

The project: “A CACTUS” is meant to assess the feasibility of commercialising the developed method for counting and sorting CTCs and develop a proper commercialisation strategy. The final goal of this project is to develop a proposition package consisting of technical proof of concept, the business proposition and strategy and an IP portfolio and strategy. This information will be presented in an attractive business plan that will be proposed to potential investors.

 Publications

year authors and title journal last update
List of publications.
2016 Fabio Del Ben, Matteo Turetta, Giorgia Celetti, Aigars Piruska, Michela Bulfoni, Daniela Cesselli, Wilhelm T. S. Huck, Giacinto Scoles
A Method for Detecting Circulating Tumor Cells Based on the Measurement of Single-Cell Metabolism in Droplet-Based Microfluidics
published pages: 8581-8584, ISSN: 1433-7851, DOI: 10.1002/anie.201602328 		Angewandte Chemie International Edition 55/30 2019-07-23

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