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4DHeart SIGNED

4D analysis of heart development and regeneration using advanced light microscopy

Total Cost €

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EC-Contrib. €

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Partnership

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 4DHeart project word cloud

Explore the words cloud of the 4DHeart project. It provides you a very rough idea of what is the project "4DHeart" about.

researcher    intersectorial    manipulation    zebrafish    hearts    perinatally    cells    biocomputing    heart    packages    esrs    model    resolution    sheet    morphogenesis    questions    microscopy    vivo    underscore    modeling    facts    bioimaging    precision    screenings    science    generate    filling    environmental    smes    cardiovascular    tweezers    leads    life    ischemic    market    software    20    throughput    organisms    adult    frontier    larvae    academic    gap    will    introducing    physics    altering    imaging    profile    embryonic    found    image    lsm    genetic    suitable    mouse    influence    monitoring    deaths    bioengineer    death    companies    regeneration    multidisciplinary    disease    congenital    adapt    biological    training    revolutionary    cellular    light    biophysical    skills    stage    cardiac    handling    complete    defects    protocols    softwares    worldwide    dataset    adulthood    visualizing    toolbox    acquisition    optical    receive    cv    epigenetic    interface    interrogate    later   

Project "4DHeart" data sheet

The following table provides information about the project.

Coordinator
CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) 

Organization address
address: CALLE MELCHOR FERNANDEZ ALMAGRO 3
city: MADRID
postcode: 28029
website: www.cnic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website http://www.4dheart.eu/
 Total cost 1˙529˙110 €
 EC max contribution 1˙529˙110 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2016
 Funding Scheme MSCA-ITN-EID
 Starting year 2017
 Duration (year-month-day) from 2017-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) ES (MADRID) coordinator 247˙872.00
2    UNIVERSITAET BERN CH (BERN) participant 265˙226.00
3    CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE FR (ILLKIRCH GRAFFENSTADEN) participant 262˙875.00
4    Leica Microsystems CMS GmbH DE (Wetzlar) participant 249˙216.00
5    PHILIPS IBERICA SA ES (MADRID) participant 247˙872.00
6    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) participant 131˙437.00
7    DITABIS DIGITAL BIOMEDICAL IMAGING SYSTEMS AG DE (PFORZHEIM) participant 124˙608.00
8    ACQUIFER AG DE (PFORZHEIM) participant 0.00
9    ECOLE POLYTECHNIQUE FR (PALAISEAU CEDEX) partner 0.00
10    FONDATION DE L'INSTITUT DE RECHERCHE IDIAP CH (MARTIGNY) partner 0.00
11    INSTITUTO DE EMPRESA SL ES (MADRID) partner 0.00
12    Juan Sarasua BE (Brussels) partner 0.00
13    UNIVERSIDAD AUTONOMA DE MADRID ES (MADRID) partner 0.00
14    UNIVERSIDAD CARLOS III DE MADRID ES (GETAFE (MADRID)) partner 0.00
15    UNIVERSITE DE STRASBOURG FR (STRASBOURG) partner 0.00

Map

 Project objective

Cardiovascular (CV) disease is a main cause of death worldwide. During adulthood, ischemic heart disease leads to heart failure and perinatally, congenital heart defects are found in over 20% of deaths. Moreover, genetic or epigenetic factors altering development can have an impact much later in life. These facts underscore the need of a better understanding of the genetic and environmental factors that influence CV development. An important way to increase our knowledge is by visualizing cardiac development in vivo. Recent advance in microscopy allows monitoring CV development at a cellular level in organisms such as the zebrafish model. Particularly revolutionary has been the development of light sheet microscopy (LSM). We want to further exploit LSM for in vivo manipulation of cells in the embryonic zebrafish heart and measure with high precision biophysical parameters, by introducing novel features to LSM such as optical tweezers. High throughput cardiac imaging protocols for zebrafish larvae suitable for screenings will be set up. We will develop softwares to enhance resolution of acquisition, large dataset handling and image-processing. The aim is to generate a toolbox to be implemented into existing software packages allowing a complete modeling of zebrafish cardiac morphogenesis. We will adapt LSM for adult zebrafish hearts to study cardiac regeneration and mouse heart development at cellular resolution. Each Early Stage Researchers (ESRs) will develop their own technology to solve a biological problem at the frontier of knowledge. ESRs will receive multidisciplinary (CV development, physics, biocomputing, bioimaging) as well as intersectorial (academic research, SMEs, large companies) training and will achieve unique skills on microscopy, in-vivo imaging and image analysis allowing them to interrogate questions on cardiac development and regeneration. Their profile will be at the interface of a bioengineer and a life science researcher filling a currently existing gap on the market.

 Publications

year authors and title journal last update
List of publications.
2019 Marina Peralta1,2,3,4, Katerina Jerabkova1,2,3,4*, Tommaso Lucchesi5,6,7*, Laia Ortiz Lopez1,2,3,4, 5 Benjamin Vitre8, Dong Han5,6, Laurent Guillemot5,6, Chaitanya Dingare9, Izabela Sumara1,2,3,4, 6 Nadia Mercader10,11, Virginie Lecaudey9, Benedicte Delaval8, Sigolène M. Meilhac5,6 and 7 Julien Vermot1,2,3,4
Intraflagellar transport complex B proteins regulate the Hippo effector Yap1 during cardiogenesis
published pages: , ISSN: , DOI: 10.1101/777128
https://doi.org/10.1101/777128 2019-11-26
2019 Ines J. Marques, Eleonora Lupi, Nadia Mercader
Model systems for regeneration: zebrafish
published pages: dev167692, ISSN: 0950-1991, DOI: 10.1242/dev.167692
Development 146/18 2019-10-03

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