Explore the words cloud of the 4DHeart project. It provides you a very rough idea of what is the project "4DHeart" about.
The following table provides information about the project.
CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.)
|Coordinator Country||Spain [ES]|
|Total cost||1˙529˙110 €|
|EC max contribution||1˙529˙110 € (100%)|
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
|Duration (year-month-day)||from 2017-01-01 to 2020-12-31|
Take a look of project's partnership.
|1||CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.)||ES (MADRID)||coordinator||247˙872.00|
|2||UNIVERSITAET BERN||CH (BERN)||participant||265˙226.00|
|3||CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE||FR (ILLKIRCH GRAFFENSTADEN)||participant||262˙875.00|
|4||Leica Microsystems CMS GmbH||DE (Wetzlar)||participant||249˙216.00|
|5||PHILIPS IBERICA SA||ES (MADRID)||participant||247˙872.00|
|6||CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS||FR (PARIS)||participant||131˙437.00|
|7||DITABIS DIGITAL BIOMEDICAL IMAGING SYSTEMS AG||DE (PFORZHEIM)||participant||124˙608.00|
|8||ACQUIFER AG||DE (PFORZHEIM)||participant||0.00|
|9||ECOLE POLYTECHNIQUE||FR (PALAISEAU CEDEX)||partner||0.00|
|10||FONDATION DE L'INSTITUT DE RECHERCHE IDIAP||CH (MARTIGNY)||partner||0.00|
|11||INSTITUTO DE EMPRESA SL||ES (MADRID)||partner||0.00|
|12||Juan Sarasua||BE (Brussels)||partner||0.00|
|13||UNIVERSIDAD AUTONOMA DE MADRID||ES (MADRID)||partner||0.00|
|14||UNIVERSIDAD CARLOS III DE MADRID||ES (GETAFE (MADRID))||partner||0.00|
|15||UNIVERSITE DE STRASBOURG||FR (STRASBOURG)||partner||0.00|
Cardiovascular (CV) disease is a main cause of death worldwide. During adulthood, ischemic heart disease leads to heart failure and perinatally, congenital heart defects are found in over 20% of deaths. Moreover, genetic or epigenetic factors altering development can have an impact much later in life. These facts underscore the need of a better understanding of the genetic and environmental factors that influence CV development. An important way to increase our knowledge is by visualizing cardiac development in vivo. Recent advance in microscopy allows monitoring CV development at a cellular level in organisms such as the zebrafish model. Particularly revolutionary has been the development of light sheet microscopy (LSM). We want to further exploit LSM for in vivo manipulation of cells in the embryonic zebrafish heart and measure with high precision biophysical parameters, by introducing novel features to LSM such as optical tweezers. High throughput cardiac imaging protocols for zebrafish larvae suitable for screenings will be set up. We will develop softwares to enhance resolution of acquisition, large dataset handling and image-processing. The aim is to generate a toolbox to be implemented into existing software packages allowing a complete modeling of zebrafish cardiac morphogenesis. We will adapt LSM for adult zebrafish hearts to study cardiac regeneration and mouse heart development at cellular resolution. Each Early Stage Researchers (ESRs) will develop their own technology to solve a biological problem at the frontier of knowledge. ESRs will receive multidisciplinary (CV development, physics, biocomputing, bioimaging) as well as intersectorial (academic research, SMEs, large companies) training and will achieve unique skills on microscopy, in-vivo imaging and image analysis allowing them to interrogate questions on cardiac development and regeneration. Their profile will be at the interface of a bioengineer and a life science researcher filling a currently existing gap on the market.
|year||authors and title||journal||last update|
Marina Peralta1,2,3,4, Katerina Jerabkova1,2,3,4*, Tommaso Lucchesi5,6,7*, Laia Ortiz Lopez1,2,3,4,
5 Benjamin Vitre8, Dong Han5,6, Laurent Guillemot5,6, Chaitanya Dingare9, Izabela Sumara1,2,3,4,
6 Nadia Mercader10,11, Virginie Lecaudey9, Benedicte Delaval8, SigolÃ¨ne M. Meilhac5,6 and
7 Julien Vermot1,2,3,4
Intraflagellar transport complex B proteins regulate the Hippo effector Yap1 during cardiogenesis
published pages: , ISSN: , DOI: 10.1101/777128
Ines J. Marques, Eleonora Lupi, Nadia Mercader
Model systems for regeneration: zebrafish
published pages: dev167692, ISSN: 0950-1991, DOI: 10.1242/dev.167692
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The information about "4DHEART" are provided by the European Opendata Portal: CORDIS opendata.