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MAGICBULLET

Peptide-Drug Conjugates for Targeted Delivery in Tumor Therapy

Total Cost €

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EC-Contrib. €

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Partnership

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 MAGICBULLET project word cloud

Explore the words cloud of the MAGICBULLET project. It provides you a very rough idea of what is the project "MAGICBULLET" about.

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Project "MAGICBULLET" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET BIELEFELD 

Organization address
address: UNIVERSITAETSSTRASSE 25
city: BIELEFELD
postcode: 33615
website: www.uni-bielefeld.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.magicbullet.de
 Total cost 3˙746˙420 €
 EC max contribution 3˙746˙420 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2014
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-01-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET BIELEFELD DE (BIELEFELD) coordinator 498˙432.00
2    HELSINGIN YLIOPISTO FI (HELSINGIN YLIOPISTO) participant 538˙290.00
3    UNIVERSITA DEGLI STUDI DELL'INSUBRIA IT (VARESE) participant 516˙122.00
4    UNIVERSITA DEGLI STUDI DI MILANO IT (MILANO) participant 516˙122.00
5    HEIDELBERG PHARMA RESEARCH GMBH DE (LADENBURG) participant 498˙432.00
6    EOTVOS LORAND TUDOMANYEGYETEM HU (BUDAPEST) participant 447˙827.00
7    EXIRIS SRL IT (ROMA) participant 258˙061.00
8    UNIVERSITAET ZU KOELN DE (KOELN) participant 249˙216.00
9    Orszagos Onkologiai Intezet HU (Budapest) participant 223˙913.00
10    Bayer Pharma AG DE (Berlin) partner 0.00
11    FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. DE (MUNCHEN) partner 0.00
12    FRIEDRICH-ALEXANDER-UNIVERSITAET ERLANGEN NUERNBERG DE (ERLANGEN) partner 0.00
13    IRBM SCIENCE PARK SPA IT (POMEZIA RM) partner 0.00
14    Kineto Lab Ltd. HU (Budapest) partner 0.00

Map

 Project objective

Many tumor cells are characterized by the overexpression of certain antigens. Molecules that specifically recognize these structures are suitable as homing devices in tumor therapy. Conjugates of anticancer drugs with such a delivery vector targeting tumors would be a “magic bullet” according to the Nobel laureate Paul Ehrlich. Three antibody-drug conjugates (ADC) have already been approved for anticancer therapy. However, ADC have e.g. limitations with respect to tumor penetration, high manufacturing costs, and require challenging conjugation chemistry. Peptide-drug conjugates can have a high drug loading, easily penetrate tissue, and can be easily prepared in a homogenous form with straightforward and well-defined conjugation chemistry. The ETN MAGICBULLET will focus on chemistry-driven approaches toward conjugates between peptides (delivery vectors) that recognize tumors and anticancer drugs (payloads or warheads) in order to selectively fight cancer, a topic with a high demand of research activities. The ETN will develop and validate an array of new peptide-drug conjugates combining either known tumor-specific peptides or newly discovered tumor-homing peptides with potent cytotoxic drugs. The tumor-selective peptides are designed for cellular uptake mediated either by endocytosis or by cell-penetrating peptides. The consortium of the ETN MAGICBULLET covers tumor biology, biochemistry, pharmacology, synthetic chemistry, medicinal chemistry, spectroscopy, conformational analysis, and computational chemistry. The training program focuses on multidisciplinary research to explore and validate molecular targets for innovative treatment or investigations on the molecular mechanisms in organ-specific metastatic growth processes. It aims at scientific multilingualism and relies e.g. on concerted learning, a combination of introductory training, hands-on learning “on the bench”, teaching by peers, and training in additional skills.

 Deliverables

List of deliverables.
Summer School Other 2019-07-23 08:35:18
Feature article on Peptide-Drug Conjugates Documents, reports 2019-07-23 08:35:18
Videos Websites, patent fillings, videos etc. 2019-07-23 08:35:18
Special issue on Peptide-Drug Conjugates Documents, reports 2019-07-23 08:35:18
International Network Symposium Other 2019-07-23 08:35:18
Completion of Website Websites, patent fillings, videos etc. 2019-07-23 08:35:17

Take a look to the deliverables list in detail:  detailed list of MAGICBULLET deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Eduard Figueras, Adina Borbély, Mohamed Ismail, Marcel Frese, Norbert Sewald
Novel unit B cryptophycin analogues as payloads for targeted therapy
published pages: 1281-1286, ISSN: 1860-5397, DOI: 10.3762/bjoc.14.109
Beilstein Journal of Organic Chemistry 14 2019-07-23
2018 Andrea Angelo Pierluigi Tripodi, Szilárd Tóth, Kata Nóra Enyedi, Gitta Schlosser, Gergely Szakács, Gábor Mező
Development of novel cyclic NGR peptide–daunomycin conjugates with dual targeting property
published pages: 911-918, ISSN: 1860-5397, DOI: 10.3762/bjoc.14.78
Beilstein Journal of Organic Chemistry 14 2019-07-23
2018 Lizeth Bodero, Paula López Rivas, Barbara Korsak, Torsten Hechler, Andreas Pahl, Christoph Müller, Daniela Arosio, Luca Pignataro, Cesare Gennari, Umberto Piarulli
Synthesis and biological evaluation of RGD and isoDGR peptidomimetic-α-amanitin conjugates for tumor-targeting
published pages: 407-415, ISSN: 1860-5397, DOI: 10.3762/bjoc.14.29
Beilstein Journal of Organic Chemistry 14 2019-07-23
2018 Samuele Cazzamalli, Eduard Figueras, Lilla Pethő, Adina Borbély, Christian Steinkühler, Dario Neri, Norbert Sewald
In Vivo Antitumor Activity of a Novel Acetazolamide–Cryptophycin Conjugate for the Treatment of Renal Cell Carcinomas
published pages: 14726-14731, ISSN: 2470-1343, DOI: 10.1021/acsomega.8b02350
ACS Omega 3/11 2019-07-23
2017 Christine Weiss, Eduard Figueras, Adina N. Borbely, Norbert Sewald
Cryptophycins: cytotoxic cyclodepsipeptides with potential for tumor targeting
published pages: 514-531, ISSN: 1075-2617, DOI: 10.1002/psc.3015
Journal of Peptide Science 23/7-8 2019-07-23
2018 Sabine Schuster, Beáta Biri-Kovács, Bálint Szeder, László Buday, János Gardi, Zsuzsanna Szabó, Gábor Halmos, Gábor Mező
Enhanced In Vitro Antitumor Activity of GnRH-III-Daunorubicin Bioconjugates Influenced by Sequence Modification
published pages: 223, ISSN: 1999-4923, DOI: 10.3390/pharmaceutics10040223
Pharmaceutics 10/4 2019-07-23
2018 Paula López Rivas, Ivan Ranđelović, André Raposo Moreira Dias, Arianna Pina, Daniela Arosio, József Tóvári, Gábor Mező, Alberto Dal Corso, Luca Pignataro, Cesare Gennari
Synthesis and Biological Evaluation of Paclitaxel Conjugates Involving Linkers Cleavable by Lysosomal Enzymes and α V β 3 -Integrin Ligands for Tumor Targeting
published pages: 2902-2909, ISSN: 1434-193X, DOI: 10.1002/ejoc.201800447
European Journal of Organic Chemistry 2018/23 2019-07-23
2017 Anja Gronewold, Mareike Horn, Ivan Ranđelović, Dr. József Tóvári, Sergio Muñoz Vázquez, Prof. Dr. Klaus Schomäcker, Prof. Dr. Ines Neundorf
Characterization of a Cell-Penetrating Peptide with Potential Anticancer Activity
published pages: 42–49, ISSN: 1860-7187, DOI: 10.1002/cmdc.201600498
ChemMedChem Januar 5, 2017, Volume 12, Issu 2019-07-23
2017 Simone Zanella, Simona Angerani, Arianna Pina, Paula López Rivas, Clelia Giannini, Silvia Panzeri, Daniela Arosio, Michele Caruso, Fabio Gasparri, Ivan Fraietta, Clara Albanese, Aurelio Marsiglio, Luca Pignataro, Laura Belvisi, Umberto Piarulli, Cesare Gennari
Tumor Targeting with an iso DGR-Drug Conjugate
published pages: 7910-7914, ISSN: 0947-6539, DOI: 10.1002/chem.201701844
Chemistry - A European Journal 23/33 2019-07-23
2017 André Raposo Moreira Dias, Arianna Pina, Alberto Dal Corso, Daniela Arosio, Laura Belvisi, Luca Pignataro, Michele Caruso, Cesare Gennari
Multivalency Increases the Binding Strength of RGD Peptidomimetic-Paclitaxel Conjugates to Integrin α V β 3
published pages: 14410-14415, ISSN: 0947-6539, DOI: 10.1002/chem.201703093
Chemistry - A European Journal 23/58 2019-07-23
2018 Sabine Schuster, Beáta Biri-Kovács, Bálint Szeder, Viktor Farkas, László Buday, Zsuzsanna Szabó, Gábor Halmos, Gábor Mező
Synthesis and in vitro biochemical evaluation of oxime bond-linked daunorubicin–GnRH-III conjugates developed for targeted drug delivery
published pages: 756-771, ISSN: 1860-5397, DOI: 10.3762/bjoc.14.64
Beilstein Journal of Organic Chemistry 14 2019-07-23
2017 Lucia Feni, M. Omrane, Moritz Fischer, Boris Zlatopolskiy, Bernd Neumaier, Ines Neundorf
Convenient Preparation of 18F-Labeled Peptide Probes for Potential Claudin-4 PET Imaging
published pages: 99, ISSN: 1424-8247, DOI: 10.3390/ph10040099
Pharmaceuticals 10/4 2019-07-23

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