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ClickGene SIGNED

Click Chemistry for Future Gene Therapies to Benefit Citizens, Researchers and Industry

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EC-Contrib. €

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Partnership

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 ClickGene project word cloud

Explore the words cloud of the ClickGene project. It provides you a very rough idea of what is the project "ClickGene" about.

skills    strength    limitations    commercial    toxicity    networking    nucleic    cross    atdbio    biomimetic    diagnostic    esrs    train    disease    site    workshops    expertise    industries    questions    baseclick    highlycompetitive    epigenetic    biopharmaceutical    optogenetic    engineering    mutagenesis    productive    lipidome    academic    biodiagnostic    match    nanotechnology    engaging    disciplinary    underlying    nucleases    nanoparticle    insertional    leaders    synergy    secondment    edge    selective    tissues    detection    off    gene    lipinutragen    chemistry    outstanding    training    biomaterials    thereby    delivering    probes    medicine    play    network    members    biological    clickgene    industry    innovative    14    cm1201    cells    diagnostics    scientific    correcting    optimal    liposomal    efficiency    education    possess    commercialisation    undesirable    combination    action    regarding    generation    genetic    personalised    allied    original    causes    vital    reputations    click    chemists    acid    base    cutting    intersectorial    radical    therapy    drug    international    transferable   

Project "ClickGene" data sheet

The following table provides information about the project.

Coordinator
DUBLIN CITY UNIVERSITY 

Organization address
address: Glasnevin
city: DUBLIN
postcode: 9
website: www.dcu.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website http://www.clickgene.eu
 Total cost 3˙556˙990 €
 EC max contribution 3˙556˙990 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2014
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-01-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DUBLIN CITY UNIVERSITY IE (DUBLIN) coordinator 797˙023.00
2    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 498˙432.00
3    "NATIONAL CENTER FOR SCIENTIFIC RESEARCH ""DEMOKRITOS""" EL (AGIA PARASKEVI) participant 484˙773.00
4    USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I. CZ (PRAHA 6) participant 464˙844.00
5    ATDBIO LIMITED UK (SOUTHAMPTON HAMPSHIRE) participant 273˙287.00
6    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 273˙287.00
7    CONSIGLIO NAZIONALE DELLE RICERCHE IT (ROMA) participant 258˙061.00
8    LIPINUTRAGEN SOCIETA A RESPONSABILITA LIMITATA IT (BOLOGNA) participant 258˙061.00
9    BASECLICK GMBH DE (NEURIED) participant 249˙216.00
10    ACCELOPMENT AG CH (ZUERICH) partner 0.00
11    ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA IT (BOLOGNA) partner 0.00
12    ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON EL (ATHINA) partner 0.00
13    Link Technologies Ltd UK (Bellshill) partner 0.00
14    LipiNutraMed Ltd EL (Aghia Paraskevi, Athens) partner 0.00
15    metabion GmbH DE (Planegg) partner 0.00
16    NATIONAL TECHNICAL UNIVERSITY OF ATHENS - NTUA EL (ATHINA) partner 0.00
17    Peakdale Molecular Limited UK (Chapel-en-le-Frith) partner 0.00
18    UNIVERZITA KARLOVA CZ (PRAHA 1) partner 0.00

Map

 Project objective

Gene therapy is expected to play a key role in next-generation medicine by correcting the underlying genetic causes of disease, thereby facilitating personalised medicine. Current gene therapy methods possess undesirable side effects, including insertional mutagenesis, toxicity, low efficiency and off-target cutting. Questions also remain regarding the optimal methods for delivering nucleases into cells and tissues. These limitations will be addressed through the original and innovative approach of the ClickGene network.

ClickGene’s research objectives are to train 14 ESRs in the field of biomaterials development with specific focus on, i.) site-selective genetic engineering, ii.) liposomal nanoparticle drug delivery, and iii.) optogenetic diagnostic probes for epigenetic base detection. Most of our academic partners are key members of COST Action CM1201: Biomimetic Radical Chemistry and all have outstanding international reputations as scientific leaders in their field. This COST Action will play a vital role in both networking and training elements of ClickGene, and in combination with transferable skills training, intersectorial and cross-disciplinary secondment, and industry targeted workshops, the education of biomaterials chemists with expertise in click-chemistry and cutting edge application areas of gene therapy, nanotechnology and biological diagnostics will be achieved.

The training provided will match the skills required by next-generation research leaders in biopharmaceutical, nanotechnology, biodiagnostic and other industries. Allied to academic strength in this network, ClickGene features highlycompetitive industry partners with expertise in commercialisation of nucleic acid click-chemistry (baseclick, ATDBio) and liposomal and lipidome technology (LipiNutraGen). Thus, synergy between both commercial and academic partners will enable ESRs to develop gene-targeted technology within a highly productive, engaging, and exciting training network.

 Deliverables

List of deliverables.
Summer School “Enzymatic Chemical Nucleases” Other 2019-06-06 15:52:33
SCNAC conference in Ceske Krumlov 2018 Other 2019-06-06 15:52:37
Video Websites, patent fillings, videos etc. 2019-06-06 15:52:34
 FAQ sessions in schools Websites, patent fillings, videos etc. 2019-06-06 15:52:34
Website Websites, patent fillings, videos etc. 2019-03-04 11:00:29
Social media Websites, patent fillings, videos etc. 2019-02-12 12:35:33

Take a look to the deliverables list in detail:  detailed list of ClickGene deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Alessandro Panattoni, Radek Pohl, Michal Hocek
Flexible Alkyne-Linked Thymidine Phosphoramidites and Triphosphates for Chemical or Polymerase Synthesis and Fast Postsynthetic DNA Functionalization through Copper-Catalyzed Alkyne–Azide 1,3-Dipolar Cycloaddition
published pages: 3962-3965, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.8b01533
Organic Letters 20/13 2019-03-11
2018 Ilenia Manuguerra, Stefano Croce, Afaf H. El-Sagheer, Abhichart Krissanaprasit, Tom Brown, Kurt V. Gothelf, Antonio Manetto
Gene assembly via one-pot chemical ligation of DNA promoted by DNA nanostructures
published pages: 4529-4532, ISSN: 1359-7345, DOI: 10.1039/c8cc00738a
Chemical Communications 54/36 2019-03-11
2018 Gianluca Toniolo, Maria Louka, Georgia Menounou, Nicolò Zuin Fantoni, George Mitrikas, Eleni K. Efthimiadou, Annalisa Masi, Massimo Bortolotti, Letizia Polito, Andrea Bolognesi, Andrew Kellett, Carla Ferreri, Chryssostomos Chatgilialoglu
[Cu(TPMA)(Phen)](ClO 4 ) 2 : Metallodrug Nanocontainer Delivery and Membrane Lipidomics of a Neuroblastoma Cell Line Coupled with a Liposome Biomimetic Model Focusing on Fatty Acid Reactivity
published pages: 15952-15965, ISSN: 2470-1343, DOI: 10.1021/acsomega.8b02526
ACS Omega 3/11 2019-03-11
2018 Michael Stadlmeier, Jana Bogena, Miriam Wallner, Martin Wühr, Thomas Carell
A Sulfoxide-Based Isobaric Labelling Reagent for Accurate Quantitative Mass Spectrometry
published pages: 2958-2962, ISSN: 1433-7851, DOI: 10.1002/anie.201708867
Angewandte Chemie International Edition 57/11 2019-03-11
2018 Ilenia Manuguerra, Stefano Croce, Afaf H. El-Sagheer, Abhichart Krissanaprasit, Tom Brown, Kurt V. Gothelf, Antonio Manetto
Gene assembly via one-pot chemical ligation of DNA promoted by DNA nanostructures
published pages: 4529-4532, ISSN: 1359-7345, DOI: 10.1039/c8cc00738a
Chemical Communications 54/36 2019-03-20
2017 Raddaoui, Nada; Stazzoni, Samuele; Möckl, Leonhard; Viverge, Bastien; Geiger, Florian; Engelke, Hanna; Bräuchle, Christoph; Carell, Thomas
Dendrimer-based signal amplification of click-labelled DNA in situ
published pages: 1716-1720, ISSN: 1439-4227, DOI: 10.5282/ubm/epub.60576
Chembiochem 18/17 2019-03-20
2018 Creina Slator, Zara Molphy, Vickie McKee, Conor Long, Tom Brown, Andrew Kellett
Di-copper metallodrugs promote NCI-60 chemotherapy via singlet oxygen and superoxide production with tandem TA/TA and AT/AT oligonucleotide discrimination
published pages: 2733-2750, ISSN: 0305-1048, DOI: 10.1093/nar/gky105
Nucleic Acids Research 46/6 2019-03-13
2017 Giorgia Giacometti, Marina Marini, Kyriakos Papadopoulos, Carla Ferreri, Chryssostomos Chatgilialoglu
trans-Double Bond-Containing Liposomes as Potential Carriers for Drug Delivery
published pages: 2082, ISSN: 1420-3049, DOI: 10.3390/molecules22122082
Molecules 22/12 2019-03-11
2017 Nada Raddaoui, Samuele Stazzoni, Leonhard Möckl, Bastien Viverge, Florian Geiger, Hanna Engelke, Christoph Bräuchle, Thomas Carell
Dendrimer-Based Signal Amplification of Click-Labelled DNA in Situ
published pages: 1716-1720, ISSN: 1439-4227, DOI: 10.1002/cbic.201700209
ChemBioChem 18/17 2019-03-13
2017 Paraskevi Prasinou, Ioannis Dafnis, Giorgia Giacometti, Carla Ferreri, Angeliki Chroni, Chryssostomos Chatgilialoglu
Fatty acid-based lipidomics and membrane remodeling induced by apoE3 and apoE4 in human neuroblastoma cells
published pages: 1967-1973, ISSN: 0005-2736, DOI: 10.1016/j.bbamem.2017.07.001
Biochimica et Biophysica Acta (BBA) - Biomembranes 1859/10 2019-03-13
2018 Javier Amézaga, Sara Arranz, Ander Urruticoechea, Gurutze Ugartemendia, Aitziber Larraioz, Maria Louka, Matxalen Uriarte, Carla Ferreri, Itziar Tueros
Altered Red Blood Cell Membrane Fatty Acid Profile in Cancer Patients
published pages: 1853, ISSN: 2072-6643, DOI: 10.3390/nu10121853
Nutrients 10/12 2019-03-13
2018 Gianluca Toniolo, Eleni K. Efthimiadou, George Kordas, Chryssostomos Chatgilialoglu
Development of multi-layered and multi-sensitive polymeric nanocontainers for cancer therapy: in vitro evaluation
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-32890-5
Scientific Reports 8/1 2019-03-11
2017 Giorgia Giacometti, Carla Ferreri, Anna Sansone, Chryssostomos Chatgilialoglu, Carla Marzetti, Ellas Spyratou, Alexandros G. Georgakilas, Marina Marini, Provvidenza M. Abruzzo, Alessandra Bolotta, Alessandro Ghezzo, Renato Minguzzi, Annio Posar, Paola Visconti
High predictive values of RBC membrane-based diagnostics by biophotonics in an integrated approach for Autism Spectrum Disorders
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-10361-7
Scientific Reports 7/1 2019-03-11
2018 Natasha McStay, Anthony M. Reilly, Nicholas Gathergood, Andrew Kellett
Efficient DNA Condensation by a C 3 ‐Symmetric Codeine Scaffold
published pages: 38-42, ISSN: 2192-6506, DOI: 10.1002/cplu.201800480
ChemPlusChem 84 2019-03-11
2019 Nicoló Zuin Fantoni, Zara Molphy, Creina Slator, Georgia Menounou, Gianluca Toniolo, George Mitrikas, Vickie McKee, Chryssostomos Chatgilialoglu, Andrew Kellett
Polypyridyl-Based Copper Phenanthrene Complexes: A New Type of Stabilized Artificial Chemical Nuclease
published pages: 221-237, ISSN: 0947-6539, DOI: 10.1002/chem.201804084
Chemistry - A European Journal 25/1 2019-03-11
2016 Su, Meng ; Kirchner, Angie ; Stazzoni, Samuele; Müller, Markus ; Wagner, Mirko; Schröder, Arne; Carell, Thomas
5-Formylcytosin ist vermutlich eine semi-permanente Base an definierten Genompositionen
published pages: 11974-11978, ISSN: 1521-3757, DOI: 10.5282/ubm/epub.60565
Angewandte Chemie 128/39 2019-03-20
2018 Michael Stadlmeier, Jana Bogena, Miriam Wallner, Martin Wühr, Thomas Carell
Ein auf Sulfoxid basierendes, isobares Derivatisierungsreagens für die präzise quantitative Massenspektrometrie
published pages: 3008-3013, ISSN: 0044-8249, DOI: 10.1002/ange.201708867
Angewandte Chemie 130/11 2019-03-18
2018 Sarah Walsh, Afaf Helmy El-Sagheer, Tom Brown
Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above
published pages: 7681-7687, ISSN: 2041-6520, DOI: 10.1039/c8sc02418a
Chemical Science 9/39 2019-03-11
2016 Anna Sansone, Evanthia Tolika, Maria Louka, Valentina Sunda, Simone Deplano, Michele Melchiorre, Dimitrios Anagnostopoulos, Chryssostomos Chatgilialoglu, Cesare Formisano, Rosa Di Micco, Maria Rosaria Faraone Mennella, Carla Ferreri
Hexadecenoic Fatty Acid Isomers in Human Blood Lipids and Their Relevance for the Interpretation of Lipidomic Profiles
published pages: e0152378, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0152378
PLOS ONE 11/4 2019-05-28
2015 A. Kellett, N. Fantoni, T. Lauria
Genome Engineering with Synthetic Copper Nucleases
published pages: 2623-2626, ISSN: 0936-5214, DOI: 10.1055/s-0035-1560709
Synlett 26/19 2019-05-28
2016 Ján Matyašovský, Pavla Perlíková, Vincent Malnuit, Radek Pohl, Michal Hocek
2-Substituted dATP Derivatives as Building Blocks for Polymerase-Catalyzed Synthesis of DNA Modified in the Minor Groove
published pages: 15856-15859, ISSN: 1433-7851, DOI: 10.1002/anie.201609007
Angewandte Chemie International Edition 55/51 2019-05-28
2017 Creina Slator, Zara Molphy, Vickie McKee, Andrew Kellett
Triggering autophagic cell death with a di-manganese(II) developmental therapeutic
published pages: 150-161, ISSN: 2213-2317, DOI: 10.1016/j.redox.2017.01.024
Redox Biology 12 2018-10-24
2017 Carla Ferreri, Annalisa Masi, Anna Sansone, Giorgia Giacometti, Anna Larocca, Georgia Menounou, Roberta Scanferlato, Silvia Tortorella, Domenico Rota, Marco Conti, Simone Deplano, Maria Louka, Anna Maranini, Arianna Salati, Valentina Sunda, Chryssostomos Chatgilialoglu
Fatty Acids in Membranes as Homeostatic, Metabolic and Nutritional Biomarkers: Recent Advancements in Analytics and Diagnostics
published pages: 1, ISSN: 2075-4418, DOI: 10.3390/diagnostics7010001
Diagnostics 7/1 2019-05-28
2016 Dmytro Dziuba, Petr Pospíšil, Ján Matyašovský, Jiří Brynda, Dana Nachtigallová, Lubomír Rulíšek, Radek Pohl, Martin Hof, Michal Hocek
Solvatochromic fluorene-linked nucleoside and DNA as color-changing fluorescent probes for sensing interactions
published pages: 5775-5785, ISSN: 2041-6520, DOI: 10.1039/C6SC02548J
Chem. Sci. 7/9 2019-05-28
2018 Gianluca Toniolo, Maria Louka, Georgia Menounou, Nicolò Zuin Fantoni, George Mitrikas, Eleni K. Efthimiadou, Annalisa Masi, Massimo Bortolotti, Letizia Polito, Andrea Bolognesi, Andrew Kellett, Carla Ferreri, Chryssostomos Chatgilialoglu
[Cu(TPMA)(Phen)](ClO 4 ) 2 : Metallodrug Nanocontainer Delivery and Membrane Lipidomics of a Neuroblastoma Cell Line Coupled with a Liposome Biomimetic Model Focusing on Fatty Acid Reactivity
published pages: 15952-15965, ISSN: 2470-1343, DOI: 10.1021/acsomega.8b02526
ACS Omega 3/11 2019-05-28
2019 Nicoló Zuin Fantoni, Zara Molphy, Creina Slator, Georgia Menounou, Gianluca Toniolo, George Mitrikas, Vickie McKee, Chryssostomos Chatgilialoglu, Andrew Kellett
Polypyridyl-Based Copper Phenanthrene Complexes: A New Type of Stabilized Artificial Chemical Nuclease
published pages: 221-237, ISSN: 0947-6539, DOI: 10.1002/chem.201804084
Chemistry - A European Journal 25/1 2019-05-28
2016 Marco Conti, Roberta Scanferlato, Maria Louka, Anna Sansone, Carla Marzetti, Carla Ferreri
Building up spectral libraries for mapping erythrocytes by hyperspectral dark field microscopy
published pages: 175-184, ISSN: 2212-8808, DOI: 10.3233/BSI-160133
Biomedical Spectroscopy and Imaging 5/2 2019-05-28
2016 Ján Matyašovský, Pavla Perlíková, Vincent Malnuit, Radek Pohl, Michal Hocek
2-Substituted dATP Derivatives as Building Blocks for Polymerase-Catalyzed Synthesis of DNA Modified in the Minor Groove
published pages: 16088–16091, ISSN: 1521-3757, DOI: 10.1002/ange.201609007
Angewandte Chemie 128/51 2019-05-28
2016 Meng Su, Angie Kirchner, Samuele Stazzoni, Markus Müller, Mirko Wagner, Arne Schröder, Thomas Carell
5-Formylcytosine Could Be a Semipermanent Base in Specific Genome Sites
published pages: 11797-11800, ISSN: 1433-7851, DOI: 10.1002/anie.201605994
Angewandte Chemie International Edition 55/39 2019-05-28
2016 Hana Cahová, Alessandro Panattoni, Pavel Kielkowski, Jindřich Fanfrlík, Michal Hocek
5-Substituted Pyrimidine and 7-Substituted 7-Deazapurine dNTPs as Substrates for DNA Polymerases in Competitive Primer Extension in the Presence of Natural dNTPs
published pages: 3165-3171, ISSN: 1554-8929, DOI: 10.1021/acschembio.6b00714
ACS Chemical Biology 11/11 2019-05-28
2018 Sarah Walsh, Afaf Helmy El-Sagheer, Tom Brown
Fluorogenic thiazole orange TOTFO probes stabilise parallel DNA triplexes at pH 7 and above
published pages: 7681-7687, ISSN: 2041-6520, DOI: 10.1039/c8sc02418a
Chemical Science 9/39 2019-05-28
2018 Gianluca Toniolo, Eleni K. Efthimiadou, George Kordas, Chryssostomos Chatgilialoglu
Development of multi-layered and multi-sensitive polymeric nanocontainers for cancer therapy: in vitro evaluation
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-32890-5
Scientific Reports 8/1 2019-05-28
2018 Alessandro Panattoni, Radek Pohl, Michal Hocek
Flexible Alkyne-Linked Thymidine Phosphoramidites and Triphosphates for Chemical or Polymerase Synthesis and Fast Postsynthetic DNA Functionalization through Copper-Catalyzed Alkyne–Azide 1,3-Dipolar Cycloaddition
published pages: 3962-3965, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.8b01533
Organic Letters 20/13 2019-05-28

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