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BIOGEL

Engineering responsive and biomimetic hydrogels for biomedical therapeutic and diagnostic applications

Total Cost €

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EC-Contrib. €

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Partnership

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 BIOGEL project word cloud

Explore the words cloud of the BIOGEL project. It provides you a very rough idea of what is the project "BIOGEL" about.

young    2d    efficient    synthetic    cardiovascular    regeneration    hydrogel    dynamic    interlink    packages    viability    tools    situ    stimulate    directed    respectively    serve    bioactive    3d    rounded    integration    matrix    living    macromolecules    coatings    body    intersectoral    incorporation    medical    interdisciplinary    minimal    structural    hydrogels    tissue    chemistries    topographical    biohybrid    education    clinically    scientists    undergo    responsive    functional    engineer    templates    repair    training    spatial    career    resemble    translational    engineering    focussed    interwoven    interaction    stimuli    biogel    cells    biohybridisation    biomedical    educate    orchestrate    bioactivities    parts    precursors    direct    phd    extracellular    platform    gelation    cell    nerve    mechanical    units    bone    emphasis    implants    behavior    translatable    therapeutic    interface    innovative    invasive    follows    subunits    temporal    components    diagnostic    cartilage    receptor    flexible    first    efficacy    international    tailor    biointegrative    skills   

Project "BIOGEL" data sheet

The following table provides information about the project.

Coordinator
DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV 

Organization address
address: FORCKENBECKSTRASSE 50
city: AACHEN
postcode: 52074
website: www.dwi.rwth-aachen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.biogel-mariecurie.eu
 Total cost 3˙522˙760 €
 EC max contribution 3˙522˙760 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2014
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-01-01   to  2018-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV DE (AACHEN) coordinator 1˙032˙448.00
2    AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH AT (WIEN) participant 511˙868.00
3    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) participant 510˙748.00
4    LIFETEC GROUP BV NL (EINDHOVEN) participant 255˙374.00
5    NovioSense BV NL (Nijmegen) participant 255˙374.00
6    PEPSCAN THERAPEUTICS BV NL (LELYSTAD) participant 255˙374.00
7    TECHNICAL PROTEINS NANOBIOTECHNOLOGY SL ES (VALLADOLID) participant 247˙872.00
8    UNIVERSIDAD DE VALLADOLID ES (VALLADOLID) participant 247˙872.00
9    ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS EL (THERMI THESSALONIKI) participant 205˙826.00
10    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) partner 0.00
11    OSAKA UNIVERSITY JP (OSAKA) partner 0.00
12    Synolyne Pharma BE (HERSTAL) partner 0.00
13    THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA CORP US (PHILADELPHIA) partner 0.00

Map

 Project objective

BIOGEL is set up to educate young scientists to develop innovative hydrogel chemistries and systems for biomedical applications. The first objective is to provide a platform for young researchers to undergo a well-rounded PhD education, particularly focussed on translational skills for a career focused in biomedical research and medical technology development. The second objective is to engineer functional and responsive hydrogels, which resemble specific properties of the extracellular matrix. The third objective is (i) to enhance the efficacy of medical devices by 2D biointegrative coatings that direct and orchestrate the interface to living cells and tissue and enable improved integration within the body, (ii) to advance therapeutic measures by 3D templates for tissue repair, and (iii) to enable new diagnostic tools by responsive diagnostic hydrogels. BIOGEL follows an international, interdisciplinary, and intersectoral approach organized in 9 and 8 interwoven work and training packages respectively. The training and research parts are focused on synthetic and biohybrid macromolecules to build clinically translatable hydrogels with specific, application directed bioactivities. In order to enable efficient biohybridisation and minimal invasive application, emphasis is set on in situ gelation of precursors that do not affect the viability of cells and living tissue and that can interlink bioactive subunits to stimulate tissue regeneration, and serve as a functional component in biomedical devices. Structural incorporation of such units must be flexible, dynamic, and responsive to stimuli. This is directed to enhance cell behavior and receptor interaction, tailor the mechanical properties, and enable spatial, temporal, and topographical control of functional components. Translational aspects focus on coatings of medical devices, diagnostic hydrogels, cartilage and bone repair, tissue engineering for cardiovascular implants, and nerve regeneration.

 Deliverables

List of deliverables.
Workshop 6 Websites, patent fillings, videos etc. 2019-09-06 09:59:09
Newsletters Documents, reports 2019-09-06 09:59:10
Open ITN day Websites, patent fillings, videos etc. 2019-09-06 09:59:09
Optical characterization methods Demonstrators, pilots, prototypes 2019-09-06 09:59:09
Workshop 7 Websites, patent fillings, videos etc. 2019-09-06 09:59:10
International conference Websites, patent fillings, videos etc. 2019-09-06 09:59:09
14 (anticipated) PhD diplomas Documents, reports 2019-09-06 09:59:10
A Blogspot into the BIOGEL website Websites, patent fillings, videos etc. 2019-09-06 09:59:09
Ambassador Day Websites, patent fillings, videos etc. 2019-09-06 09:59:09
Bicyclic peptides Demonstrators, pilots, prototypes 2019-09-06 09:59:09
Workshop 4 Websites, patent fillings, videos etc. 2019-09-06 09:59:09
Workshop 1 Websites, patent fillings, videos etc. 2019-09-06 09:59:09
Workshop 3 Websites, patent fillings, videos etc. 2019-09-06 09:59:09
Workshop 2 Websites, patent fillings, videos etc. 2019-09-06 09:59:09
Completion of Recruitment Other 2019-09-06 09:59:09
Summer School Websites, patent fillings, videos etc. 2019-09-06 09:59:09
Workshop 5 Websites, patent fillings, videos etc. 2019-09-06 09:59:09
Design BIOGEL Website Websites, patent fillings, videos etc. 2019-09-06 09:59:09

Take a look to the deliverables list in detail:  detailed list of BIOGEL deliverables.

 Publications

year authors and title journal last update
List of publications.
2017 Dominik Bernhagen, Laura De Laporte, Peter Timmerman
High-Affinity RGD-Knottin Peptide as a New Tool for Rapid Evaluation of the Binding Strength of Unlabeled RGD-Peptides to α v β 3 , α v β 5 , and α 5 β 1 Integrin Receptors
published pages: 5991-5997, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.7b00554
Analytical Chemistry 89/11 2019-09-06
2019 Filippo Cipriani, Dominik Bernhagen, Carmen Garcia-Arévalo, Israel González de Torre, Peter Timmerman, Jose Carlos Rodriguez-Cabello
Bicyclic RGD peptides with high integrin αvβ3 and α5β1 affinity promote cell adhesion on elastin-like recombinamers
published pages: , ISSN: 1748-6041, DOI: 10.1088/1748-605x/aafd83
Biomedical Materials 2019-09-06
2018 Filippo Cipriani, Melanie Krüger, Israel Gonzalez de Torre, Luis Quintanilla Sierra, Matilde Alonso Rodrigo, Linda Kock, José Carlos Rodriguez-Cabello
Cartilage Regeneration in Preannealed Silk Elastin-Like Co-Recombinamers Injectable Hydrogel Embedded with Mature Chondrocytes in an Ex Vivo Culture Platform
published pages: 4333-4347, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.8b01211
Biomacromolecules 19/11 2019-09-06
2018 Adrian Moreno, Tong Liu, Liang Ding, Irene Buzzacchera, Marina Galià, Martin Möller, Christopher J. Wilson, Gerard Lligadas, Virgil Percec
SET-LRP in biphasic mixtures of fluorinated alcohols with water
published pages: 2313-2327, ISSN: 1759-9954, DOI: 10.1039/c8py00062j
Polymer Chemistry 9/17 2019-09-06
2018 Alicja E. Kownacka, Dovile Vegelyte, Maurits Joosse, Nicoleta Anton, B. Jelle Toebes, Jan Lauko, Irene Buzzacchera, Katarzyna Lipinska, Daniela A. Wilson, Nel Geelhoed-Duijvestijn, Christopher J. Wilson
Clinical Evidence for Use of a Noninvasive Biosensor for Tear Glucose as an Alternative to Painful Finger-Prick for Diabetes Management Utilizing a Biopolymer Coating
published pages: 4504-4511, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.8b01429
Biomacromolecules 19/11 2019-09-06
2019 Irene Buzzacchera, Qi Xiao, Hong Han, Khosrow Rahimi, Shangda Li, Nina Yu. Kostina, B. Jelle Toebes, Samantha E. Wilner, Martin Möller, Cesar Rodriguez-Emmenegger, Tobias Baumgart, Daniela A. Wilson, Christopher J. Wilson, Michael L. Klein, Virgil Percec
Screening Libraries of Amphiphilic Janus Dendrimers Based on Natural Phenolic Acids to Discover Monodisperse Unilamellar Dendrimersomes
published pages: 712-727, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.8b01405
Biomacromolecules 20/2 2019-09-06
2018 Nestor Gisbert Quilis, Médéric Lequeux, Priyamvada Venugopalan, Imran Khan, Wolfgang Knoll, Souhir Boujday, Marc Lamy de la Chapelle, Jakub Dostalek
Tunable laser interference lithography preparation of plasmonic nanoparticle arrays tailored for SERS
published pages: 10268-10276, ISSN: 2040-3364, DOI: 10.1039/c7nr08905h
Nanoscale 10/21 2019-09-06
2017 Cesar Rodriguez-Emmenegger, Qi Xiao, Nina Yu. Kostina, Samuel E. Sherman, Khosrow Rahimi, Benjamin E. Partridge, Shangda Li, Dipankar Sahoo, Aracelee M. Reveron Perez, Irene Buzzacchera, Hong Han, Meir Kerzner, Ishita Malhotra, Martin Möller, Christopher J. Wilson, Matthew C. Good, Mark Goulian, Tobias Baumgart, Michael L. Klein, Virgil Percec
Encoding biological recognition in a bicomponent cell-membrane mimic
published pages: 201821924, ISSN: 0027-8424, DOI: 10.1073/pnas.1821924116
Proceedings of the National Academy of Sciences 2019-09-06
2017 Luis P. B. Guerzoni, Jan Bohl, Alexander Jans, Jonas C. Rose, Jens Koehler, Alexander J. C. Kuehne, Laura De Laporte
Microfluidic fabrication of polyethylene glycol microgel capsules with tailored properties for the delivery of biomolecules
published pages: 1549-1557, ISSN: 2047-4830, DOI: 10.1039/c7bm00322f
Biomaterials Science 5/8 2019-09-06
2017 Irene Buzzacchera, Mariia Vorobii, Nina Yu. Kostina, Andres de los Santos Pereira, Tomáš Riedel, Michael Bruns, Wojciech Ogieglo, Martin Möller, Christopher J. Wilson, Cesar Rodriguez-Emmenegger
Polymer Brush-Functionalized Chitosan Hydrogels as Antifouling Implant Coatings
published pages: 1983-1992, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.7b00516
Biomacromolecules 18/6 2019-09-06
2019 Evgenia Tsanaktsidou, Olga Kammona, Costas Kiparissides
On the synthesis and characterization of biofunctional hyaluronic acid based injectable hydrogels for the repair of cartilage lesions
published pages: 47-56, ISSN: 0014-3057, DOI: 10.1016/j.eurpolymj.2019.02.024
European Polymer Journal 114 2019-09-06
2018 Qi Xiao, Anna-Kristin Ludwig, Cecilia Romanò, Irene Buzzacchera, Samuel E. Sherman, Maria Vetro, Sabine Vértesy, Herbert Kaltner, Ellen H. Reed, Martin Möller, Christopher J. Wilson, Daniel A. Hammer, Stefan Oscarson, Michael L. Klein, Hans-Joachim Gabius, Virgil Percec
Exploring functional pairing between surface glycoconjugates and human galectins using programmable glycodendrimersomes
published pages: E2509-E2518, ISSN: 0027-8424, DOI: 10.1073/pnas.1720055115
Proceedings of the National Academy of Sciences 115/11 2019-09-06
2018 Paul H.J. Kouwer, Paula de Almeida, Onno ven den Boomen, Zaskia H. Eksteen-Akeroyd, Roel Hammink, Maarten Jaspers, Stijn Kragt, Mathijs F.J. Mabesoone, Roeland J.M. Nolte, Alan E. Rowan, Martin G.T.A. Rutten, Vincent A.A. Le Sage, Daniël C. Schoenmakers, Chengfen Xing, Jialiang Xu
Controlling the gelation temperature of biomimetic polyisocyanides
published pages: 281-284, ISSN: 1001-8417, DOI: 10.1016/j.cclet.2017.11.002
Chinese Chemical Letters 29/2 2019-09-06
2019 Kaizheng Liu, Silvia M. Mihaila, Alan Rowan, Egbert Oosterwijk, Paul H. J. Kouwer
Synthetic Extracellular Matrices with Nonlinear Elasticity Regulate Cellular Organization
published pages: 826-834, ISSN: 1525-7797, DOI: 10.1021/acs.biomac.8b01445
Biomacromolecules 20/2 2019-09-06
2019 Paula de Almeida, Maarten Jaspers, Sarah Vaessen, Oya Tagit, Giuseppe Portale, Alan E. Rowan, Paul H. J. Kouwer
Cytoskeletal stiffening in synthetic hydrogels
published pages: 609, ISSN: 2041-1723, DOI: 10.1038/s41467-019-08569-4
Nature Communications 10/1 2019-09-06
2016 Mila I. Svechtarova, Irene Buzzacchera, B. Jelle Toebes, Jan Lauko, Nicoleta Anton, Christopher J. Wilson
Sensor Devices Inspired by the Five Senses: A Review
published pages: , ISSN: 1040-0397, DOI: 10.1002/elan.201600047
Electroanalysis 2019-09-06

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