Explore the words cloud of the EpiPredict project. It provides you a very rough idea of what is the project "EpiPredict" about.
The following table provides information about the project.
UNIVERSITEIT VAN AMSTERDAM
|Coordinator Country||Netherlands [NL]|
|Total cost||2˙797˙697 €|
|EC max contribution||2˙797˙697 € (100%)|
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
|Duration (year-month-day)||from 2015-01-01 to 2018-12-31|
Take a look of project's partnership.
|1||UNIVERSITEIT VAN AMSTERDAM||NL (AMSTERDAM)||coordinator||766˙122.00|
|2||IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE||UK (LONDON)||participant||546˙575.00|
|3||DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG||DE (HEIDELBERG)||participant||498˙432.00|
|4||UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA||IT (MILANO)||participant||258˙061.00|
|5||ACADEMISCH ZIEKENHUIS GRONINGEN||NL (GRONINGEN)||participant||255˙374.00|
|6||Epiontis GmbH||DE (Berlin)||participant||249˙216.00|
|7||SZEGEDI BIOLOGIAI KUTATOKOZPONT||HU (SZEGED)||participant||223˙913.00|
|8||CLINICAGENO LIMITED||UK (COULSDON SURREY)||participant||0.00|
|9||AHT Management Kft||HU (Budapest)||partner||0.00|
|10||Biotecture Ltd||NL (Amsterdam)||partner||0.00|
|11||EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH||CH (ZUERICH)||partner||0.00|
|12||FH JOANNEUM GESELLSCHAFT MBH||AT (GRAZ)||partner||0.00|
|13||Rathenau Instituut||NL (Amsterdam)||partner||0.00|
|14||STIFTELSEN FRAUNHOFER-CHALMERS CENTRUM FOR INDUSTRIMATEMATIK||SE (GOETEBORG)||partner||0.00|
|15||Synvolux Therapeutics BV||NL (Leiden)||partner||0.00|
The mission of EpiPredict is to train a multidisciplinary cohort of young researchers in a new approach to fully exploit the epigenetics of complex diseases. The 12 early-stage researchers (ESRs) will focus on a narrowly defined case, Tamoxifen-induced resistance in Estrogen Receptor positive (ER) breast cancer, considering five resistance interacting pathways. Given the frequent Tamoxifen treatment failure, resistance prevention and reversal is an urgent clinical problem that is central in EpiPredict. The EpiPredict intersectorial training programme employs a timely systems medicine approach combining next-generation systematic epigenetic, gene/protein profiling with innovative gene-specific epigenetic interference technologies for iterative computational modelling. Together the ESRs will identify key epigenetic changes underlying Tamoxifen induced resistance. This will provide an important step towards diagnostic markers/tools to predict treatment outcome and response monitoring setting the scene for breast cancer personalized medicine. The fellows will be trained by experts from 6 academic and 2 non-academic beneficiaries and 7 partner organizations (1 academic, 6 non-academic including industrial/socio-public parties) and 5 visiting scientists, from fields ranging from epigenetics to both computation and medicine. Strong involvement of the private sector ensures exploitation of EpiPredict achievements and exposure of the ESRs to an entrepreneurial mindset. The cohort of supradisciplinary researchers represents a new generation of research leaders equipped to address complex diseases whilst taking personalized patient aspects into consideration. They will be equipped to compete successfully and succeed in their personal careers. EpiPredict will boost academia and pharma/biotech environments, providing extra impulses to drive European translational science, systems medicine, pharmaceutical industry, and Medical ICT offering ample job opportunities.
|Prizes second annual meeting||Other||2019-07-10 14:48:58|
|PhD degrees||Other||2019-07-10 14:48:58|
|Prizes fourth annual meeting||Other||2019-07-10 14:48:58|
|Prizes third annual meeting||Other||2019-07-10 14:48:58|
|Prize first annual meeting||Other||2019-07-10 14:48:57|
Take a look to the deliverables list in detail: detailed list of EpiPredict deliverables.
|year||authors and title||journal||last update|
Ã–zge Saatci, Simone Borgoni, Ã–zge Akbulut, Selvi DurmuÅŸ, Umar Raza, Erol EyÃ¼poÄŸlu, Can Alkan, Aytekin Akyol, Ã–zgÃ¼r KÃ¼tÃ¼k, Stefan Wiemann, Ã–zgÃ¼r Åžahin
Targeting PLK1 overcomes T-DM1 resistance via CDK1-dependent phosphorylation and inactivation of Bcl-2/xL in HER2-positive breast cancer
published pages: 2251-2269, ISSN: 0950-9232, DOI: 10.1038/s41388-017-0108-9
D Goubert, W F Beckman, P J Verschure, M G Rots
Epigenetic editing: towards realization of the curable genome concept
published pages: 13006, ISSN: 2057-1739, DOI: 10.1088/2057-1739/aa5cc0
|Convergent Science Physical Oncology 3/1||2019-07-10|
Thierry D.G.A. Mondeel, Stefania Astrologo, Yanfei Zhang, Hans V. Westerhoff
NET works after all? Engineering robustness through diversity
published pages: 128-137, ISSN: 2405-8963, DOI: 10.1016/j.ifacol.2018.09.007
Juan Song, David Cano Rodriguez, Melanie Winkle, Rutger A.F. Gjaltema, DÃ©sirÃ©e Goubert, Tomasz P. Jurkowski, Irene H Heijink, Marianne G. Rots, Machteld N Hylkema
Targeted epigenetic editing of SPDEF reduces mucus production in lung epithelial cells
published pages: ajplung.00059.20, ISSN: 1040-0605, DOI: 10.1152/ajplung.00059.2016
|American Journal of Physiology - Lung Cellular and Molecular Physiology||2019-07-10|
Luca Magnani, Gianmaria FrigÃ¨, Raffaella Maria Gadaleta, Giacomo Corleone, Sonia Fabris, Hermannus Kempe, Pernette J Verschure, Iros Barozzi, Valentina Vircillo, Sung-Pil Hong, Ylenia Perone, Massimo Saini, Andreas Trumpp, Giuseppe Viale, Antonino Neri, Simak Ali, Marco Angelo Colleoni, Giancarlo Pruneri, Saverio Minucci
Acquired CYP19A1 amplification is an early specific mechanism of aromatase inhibitor resistance in ERÎ± metastatic breast cancer
published pages: 444-450, ISSN: 1061-4036, DOI: 10.1038/ng.3773
|Nature Genetics 49/3||2019-07-10|
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