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EUROPOL SIGNED

EUROPOL

Total Cost €

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EC-Contrib. €

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Partnership

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 EUROPOL project word cloud

Explore the words cloud of the EUROPOL project. It provides you a very rough idea of what is the project "EUROPOL" about.

europol    eliciting    clarifying    screening    maximize    bigger    status    healthy    science    play    physics    surpass    promises    ancillary    maturity    academia    combining    synthetic    forms    structural    expertise    mass    signals    solving    nmr    phenomena    underlying    exhibiting    mr    substrates    metabolic    assembled    lower    contemporary    metabolomic    hampered    supersignals    hydrogen    conception    frontier    vivo    cell    biophysical    roles    highest    return    expanded    strategies    poor    spec    resonance    hyperpolarisation    machines    metabolomes    breadth    realized    etn    para    nature    uses    diagnosis    clinical    scope    explorations    nuclear    progress    engineering    synergies    alternatives    irreplaceable    placed    hyperpolarization    mri    dynamic    preclinical    despite    pet    chemistry    unparalleled    teaming    esrs    portfolios    experts    industry    magnetic    instruments    uncertain    perspective    prospects    training    untapped    sensitivities    polarization    biology    diseased    assembling    guiding    000x   

Project "EUROPOL" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF BIRMINGHAM 

Organization address
address: Edgbaston
city: BIRMINGHAM
postcode: B15 2TT
website: www.bham.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website http://itn-europol.eu
 Total cost 3˙960˙039 €
 EC max contribution 3˙960˙039 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2014
 Funding Scheme MSCA-ITN-ETN
 Starting year 2015
 Duration (year-month-day) from 2015-01-01   to  2019-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF BIRMINGHAM UK (BIRMINGHAM) coordinator 546˙575.00
2    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) participant 780˙901.00
3    JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN DE (FRANKFURT AM MAIN) participant 498˙432.00
4    UNIVERSITAETSKLINIKUM FREIBURG DE (FREIBURG) participant 498˙432.00
5    DANMARKS TEKNISKE UNIVERSITET DK (KGS LYNGBY) participant 290˙081.00
6    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 273˙287.00
7    THE UNIVERSITY OF NOTTINGHAM UK (NOTTINGHAM) participant 273˙287.00
8    UNIVERSITY OF YORK UK (YORK NORTH YORKSHIRE) participant 273˙287.00
9    CORTECNET FR (VOISINS LE BRETONNEUX) participant 262˙875.00
10    UNIVERSITE D'AIX MARSEILLE FR (Marseille) participant 262˙875.00
11    OXFORD INSTRUMENTS INDUSTRIAL PRODUCTS LIMITED UK (ABINGDON) participant 0.00
12    Rotem Industries Ltd. IL (Mishor Yamin) participant 0.00
13    BRUKER BIOSPIN GMBH DE (RHEINSTETTEN) partner 0.00
14    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) partner 0.00
15    GE Global Research DE (München) partner 0.00
16    UNIVERSITE DE VERSAILLES SAINT-QUENTIN-EN-YVELINES. FR (VERSAILLES) partner 0.00

Map

 Project objective

NMR and MRI play unique roles in contemporary Science, from Physics, Chemistry and Biology, to clinical research and diagnosis. Despite its irreplaceable role, further progress in NMR and MRI is hampered by sensitivities that are much lower than those of alternatives such as mass-spec, or PET. The prospects of solving this problem by “bigger machines” are uncertain and of poor return, given the high maturity already achieved by NMR/MRI. This ETN challenges this status from an untapped perspective, combining NMR/MRI with nuclear hyperpolarization eliciting signals that surpass those currently available by up to 50,000x. Focus is placed on two particular approaches, dynamic nuclear polarization and para-hydrogen-driven polarization, exhibiting the highest potential for biophysical, metabolomic, pre-clinical and clinical research. To maximize these “supersignals” we assembled leading experts in the physics and engineering of magnetic resonance, in the synthetic chemistry essential for the success of these methods, in the uses of NMR to structural/cell biology, and in preclinical and clinical MRI applications. Guiding this assembling is the conception that only by teaming together key areas of expertise, can hyperpolarisation’s promises be realized. In addition to fostering synergies among experts from academia and industry, EUROPOL will provide frontier training for ESRs in all the topics underlying the advancement of MR. This will include advanced physics, new instruments and forms of exploiting NMR/MRI’s hyperpolarisation, biophysical NMR, screening of healthy and diseased metabolomes, expanded portfolios of substrates to be targeted by in vivo MR, ancillary in cell and system biology explorations clarifying the nature of the metabolic phenomena, and in vivo hyperpolarisation strategies in MRI. This ETN is unparalleled in scope, breadth and potential for synergies.

 Deliverables

List of deliverables.
Outreach activities (ETN open days, podcast, eNewsletter etc) 2 Other 2020-02-27 14:53:25
Outreach activities (ETN open days, podcast, eNewsletter etc) 3 Other 2020-02-27 14:53:30
Outreach activities (ETN open days, podcast, eNewsletter etc) 1 Other 2019-07-10 14:43:24

Take a look to the deliverables list in detail:  detailed list of EUROPOL deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Patrick Seyfried, Marcel Heinz, György Pintér, Dean-Paulos Klötzner, Yvonne Becker, Michael Bolte, Hendrik R. A. Jonker, Lukas S. Stelzl, Gerhard Hummer, Harald Schwalbe, Alexander Heckel
Optimal Destabilization of DNA Double Strands by Single-Nucleobase Caging
published pages: 17568-17576, ISSN: 0947-6539, DOI: 10.1002/chem.201804040
Chemistry - A European Journal 24/66 2019-11-12
2018 Patrick Seyfried, Marcel Heinz, György Pintér, Dean-Paulos Klötzner, Yvonne Becker, Michael Bolte, Hendrik R. A. Jonker, Lukas S. Stelzl, Gerhard Hummer, Harald Schwalbe, Alexander Heckel
Optimal Destabilization of DNA Double Strands by Single-Nucleobase Caging
published pages: 17568-17576, ISSN: 0947-6539, DOI: 10.1002/chem.201804040
Chemistry - A European Journal 24/66 2019-10-31
2019 Raquel Saborano, Zuhal Eraslan, Jennie Roberts, Farhat L. Khanim, Patricia F. Lalor, Michelle A. C. Reed, Ulrich L. Günther
A framework for tracer-based metabolism in mammalian cells by NMR
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-37525-3
Scientific Reports 9/1 2019-09-17
2019 Joachim M.O. Vinther, Vitaliy Zhurbenko, Mohammed M. Albannay, Jan Henrik Ardenkjær-Larsen
Design of a local quasi-distributed tuning and matching circuit for dissolution DNP cross polarization
published pages: 12-20, ISSN: 0926-2040, DOI: 10.1016/j.ssnmr.2019.04.006
Solid State Nuclear Magnetic Resonance 102 2019-09-17
2018 Mihajlo Novakovic, Samuel F. Cousin, Michael J. Jaroszewicz, Rina Rosenzweig, Lucio Frydman
Looped-PROjected SpectroscopY (L-PROSY): A simple approach to enhance backbone/sidechain cross-peaks in 1 H NMR
published pages: 169-180, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2018.07.010
Journal of Magnetic Resonance 294 2019-09-17
2019 Martins Otikovs, Gregory L. Olsen, E̅riks Kupče, Lucio Frydman
Natural Abundance, Single-Scan 13 C– 13 C-Based Structural Elucidations by Dissolution DNP NMR
published pages: 1857-1861, ISSN: 0002-7863, DOI: 10.1021/jacs.8b12216
Journal of the American Chemical Society 141/5 2019-09-17
2018 Mihajlo Novakovic, Ricardo P. Martinho, Gregory L. Olsen, Michael S. Lustig, Lucio Frydman
Sensitivity-enhanced detection of non-labile proton and carbon NMR spectra on water resonances
published pages: 56-62, ISSN: 1463-9076, DOI: 10.1039/c7cp07046b
Physical Chemistry Chemical Physics 20/1 2019-09-17
2017 Alessia Michelotti, Fabien Rodrigues, Maxime Roche
Development and Scale-Up of Stereoretentive α-Deuteration of Amines
published pages: 1741-1744, ISSN: 1083-6160, DOI: 10.1021/acs.oprd.7b00227
Organic Process Research & Development 21/11 2019-09-17
2018 Soumya S. Roy, Kate M. Appleby, Elizabeth J. Fear, Simon B. Duckett
SABRE-Relay: A Versatile Route to Hyperpolarization
published pages: 1112-1117, ISSN: 1948-7185, DOI: 10.1021/acs.jpclett.7b03026
The Journal of Physical Chemistry Letters 9/5 2019-09-17
2019 Mohammed M. Albannay, Joachim M.O. Vinther, Andrea Capozzi, Vitaliy Zhurbenko, Jan Henrik Ardenkjaer-Larsen
Optimized microwave delivery in dDNP
published pages: 58-65, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2019.06.004
Journal of Magnetic Resonance 305 2019-09-17
2019 Mohammed M. Albannay, Joachim M.O. Vinther, Jan Raagaard Petersen, Vitaliy Zhurbenko, Jan Henrik Ardenkjaer-Larsen
Compact, low-cost NMR spectrometer and probe for dissolution DNP
published pages: 7-15, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2019.04.016
Journal of Magnetic Resonance 304 2019-09-17
2019 D.H. Johansen, M.M. Albannay, J.R. Petersen, V. Zhurbenko, J.H. Ardenkjær-Larsen
PIN diode driver for NMR and MRI
published pages: 114-119, ISSN: 1090-7807, DOI: 10.1016/j.jmr.2019.01.017
Journal of Magnetic Resonance 300 2019-09-17
2019 Gil Farkash, Stefan Markovic, Mihajlo Novakovic, Lucio Frydman
Enhanced hyperpolarized chemical shift imaging based on a priori segmented information
published pages: 3080-3093, ISSN: 0740-3194, DOI: 10.1002/mrm.27631
Magnetic Resonance in Medicine 81/5 2019-09-17
2018 Alexandra M. Olaru, Thomas B. R. Robertson, Jennifer S. Lewis, Alex Antony, Wissam Iali, Ryan E. Mewis, Simon B. Duckett
Extending the Scope of 19 F Hyperpolarization through Signal Amplification by Reversible Exchange in MRI and NMR Spectroscopy
published pages: 97-105, ISSN: 2191-1363, DOI: 10.1002/open.201700166
ChemistryOpen 7/1 2019-09-17
2019 Andrea Capozzi, Saket Patel, Christine Pepke Gunnarsson, Irene Marco-Rius, Arnaud Comment, Magnus Karlsson, Mathilde H. Lerche, Olivier Ouari, Jan Henrik Ardenkjaer-Larsen
Efficient Hyperpolarization of U- 13 C-Glucose Using Narrow-Line UV-Generated Labile Free Radicals
published pages: 1334-1339, ISSN: 1433-7851, DOI: 10.1002/anie.201810522
Angewandte Chemie International Edition 58/5 2019-07-10
2018 Dmitry Shishmarev, Philip W. Kuchel, Guilhem Pagès, Alan J. Wright, Richard L. Hesketh, Felix Kreis, Kevin M. Brindle
Glyoxalase activity in human erythrocytes and mouse lymphoma, liver and brain probed with hyperpolarized 13C-methylglyoxal
published pages: , ISSN: 2399-3642, DOI: 10.1038/s42003-018-0241-1
Communications Biology 1/1 2019-07-10
2016 Michael J. Jaroszewicz, Lucio Frydman, Robert W. Schurko
Relaxation-Assisted Separation of Overlapping Patterns in Ultra-Wideline NMR Spectra
published pages: 51-65, ISSN: 1089-5639, DOI: 10.1021/acs.jpca.6b10007
The Journal of Physical Chemistry A 121/1 2019-07-10
2018 Jiazheng Wang, Felix Kreis, Alan J. Wright, Richard L. Hesketh, Malcolm H. Levitt, Kevin M. Brindle
Dynamic 1 H imaging of hyperpolarized [1- 13 C]lactate in vivo using a reverse INEPT experiment
published pages: 741-747, ISSN: 0740-3194, DOI: 10.1002/mrm.26725
Magnetic Resonance in Medicine 79/2 2019-07-10
2017 Ricardo P. Martinho, Mihajlo Novakovic, Gregory L. Olsen, Lucio Frydman
Heteronuclear 1D and 2D NMR Resonances Detected by Chemical Exchange Saturation Transfer to Water
published pages: 3521-3525, ISSN: 1433-7851, DOI: 10.1002/anie.201611733
Angewandte Chemie International Edition 56/13 2019-07-10
2018 Jason Graham Skinner, Luca Menichetti, Alessandra Flori, Anna Dost, Andreas Benjamin Schmidt, Markus Plaumann, Ferdia Aiden Gallagher, Jan-Bernd Hövener
Metabolic and Molecular Imaging with Hyperpolarised Tracers
published pages: 902-918, ISSN: 1536-1632, DOI: 10.1007/s11307-018-1265-0
Molecular Imaging and Biology 20/6 2019-07-10
2018 Irene Marco-Rius, Tian Cheng, Adam P. Gaunt, Saket Patel, Felix Kreis, Andrea Capozzi, Alan J. Wright, Kevin M. Brindle, Olivier Ouari, Arnaud Comment
Photogenerated Radical in Phenylglyoxylic Acid for in Vivo Hyperpolarized 13 C MR with Photosensitive Metabolic Substrates
published pages: 14455-14463, ISSN: 0002-7863, DOI: 10.1021/jacs.8b09326
Journal of the American Chemical Society 140/43 2019-07-10
2018 Richard Mair, Alan J. Wright, Susana Ros, De-en Hu, Tom Booth, Felix Kreis, Jyotsna Rao, Colin Watts, Kevin M. Brindle
Metabolic Imaging Detects Low Levels of Glycolytic Activity That Vary with Levels of c-Myc Expression in Patient-Derived Xenograft Models of Glioblastoma
published pages: 5408-5418, ISSN: 0008-5472, DOI: 10.1158/0008-5472.can-18-0759
Cancer Research 78/18 2019-07-10

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